Serum vitamin D metabolites are not related to growth rate, bone mineral content, or serum alkaline phosphatase in male puberty

One hundred five children (49 male, 99 black) with known lead exposure indices from birth and adequate nutrient intake of calcium, phosphorus, and vitamin D were studied at 1 of 3 ages (21, 27, or 33 months) to determine the effects of chronic low to moderate lead exposure on circulating concentrations of vitamin D metabolites and bone mineral content as determined by photon absorptiometry. Univariate multiple regression analyses showed no direct relationship of blood lead levels to vitamin D metabolites or bone mineral content. Structural equation analyses which took into account potential covariates of age, season, race, and sex showed estimated declines in serum concentrations of total calcium (from 9.72 to 9.61 mg/dL), phosphorus (from 5.4 to 4.67 mg/dL), and 25-hydroxyvitamin D (from 27.24 to 25.8 ng/mL) and estimated increases in concentrations of parathyroid hormones (from 73.03 to 83.14 µL Eq/mL), 1,25-dihydroxyvitamin D (from 62.39 to 62.69 pg/mL), and bone mineral content (from 222.66 to 234.91 mg/cm) over the observed range of average lifetime blood lead concentrations (4.76 to 23.61 µg/dL, geometric mean 9.74 µg/dL). However, the only statistically significant effect of average lifetime blood lead concentration was that for phosphorus, and the multivariate test of the combined effects of lead on these six outcomes was not statistically significant (P = .2). It is concluded that significant alterations in vitamin D metabolism, calcium and phosphorus homeostasis, and bone mineral content are not present in children whose nutritional status is adequate and who experience low to moderate lead exposure.

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Effect of orthotopic liver transplantation on bone mineral content and serum vitamin D metabolites in infants and children with chronic cholestasis

Hepatology ◽

10.1002/hep.1840200308 ◽

1994 ◽

Vol 20 (3) ◽

pp. 598-603 ◽

Cited By ~ 29

Author(s):

Eric A. Argao ◽

William F. Balistreri ◽

Bruce W. Hollis ◽

Frederick C. Ryckman ◽

James E. Heubi

Keyword(s):

Vitamin D ◽

Liver Transplantation ◽

Bone Mineral Content ◽

Orthotopic Liver Transplantation ◽

Mineral Content ◽

Serum Vitamin ◽

Vitamin D Metabolites ◽

Serum Vitamin D ◽

Chronic Cholestasis ◽

In Infants And Children

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Bone Mineral Content in Infants and Children With Chronic Cholestatic Liver Disease

PEDIATRICS ◽

10.1542/peds.91.6.1151 ◽

1993 ◽

Vol 91 (6) ◽

pp. 1151-1154

Author(s):

Eric A. Argao ◽

Bonny L. Specker ◽

James E. Heubi

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Serum Vitamin ◽

Infants And Children ◽

Cholestatic Liver Disease ◽

Serum Vitamin D ◽

The Mean

Objective. To assess bone mineral content (BMC) status and serum vitamin D metabolite levels of infants and children with chronic cholestatic liver disease. To determine if severity of bone disease in these patients correlates with serum vitamin D metabolite levels. Methodology. We measured radial BMC with the use of a single-beam photon absorptiometer and serum vitamin D metabolite levels in 56 patients with chronic cholestasis seen at our institution from 1985 through 1991. Patients were divided into two groups according to age. Results. In group 1 (n = 37; age 2 to 22 months), decreased levels of BMC were seen as early as the first few months of life, with sharp decline observed with increasing age (approaching 3 to 5 standard deviations [SD] below the mean, P < .0003). Older patients (group 2, n = 19; age 2 to 20 years) had BMC values which clustered between 2 and 4 SD below the mean throughout the age range. Although a downward trend also was noted with increasing age, this was not statistically significant. Despite correction for weight-age or height-age, BMC was decreased in most of these patients. No correlation between severity of osteopenia and serum levels of 25(OH)-vitamin D and 1,25(OH)2-vitamin D was observed in either infants or older children. Conclusions. Decreased bone mineralization, as a complication of chronic cholestatic conditions, is a disease process that begins early in infancy, rapidly worsens with increasing age and hepatic dysfunction, and remains relatively stable in children with more stable liver disease.

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Tolerance, Bone Mineral Content, and Serum Vitamin D Concentration of Term Infants Fed Partially Hydrolyzed Whey-based Infant Formula

The Open Nutrition Journal ◽

10.2174/1874288201206010071 ◽

2012 ◽

Vol 6 (1) ◽

pp. 71-79 ◽

Cited By ~ 7

Author(s):

Marlene W Borschel

Keyword(s):

Vitamin D ◽

Bone Mineral Content ◽

Infant Formula ◽

Bone Mineral ◽

Mineral Content ◽

Serum Vitamin ◽

Term Infants ◽

Serum Vitamin D

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Canadian newcomer children’s bone health and vitamin D status

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2018-0705 ◽

2019 ◽

Vol 44 (7) ◽

pp. 796-803

Author(s):

Ginny Lane ◽

Christine Nisbet ◽

Susan J. Whiting ◽

Hassan Vatanparast

Keyword(s):

Vitamin D ◽

Bone Mineral Content ◽

Vitamin D Deficiency ◽

Body Fat ◽

Calcium Intake ◽

Mineral Content ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Total Body Fat ◽

Total Body

Adequate calcium intake and supply of vitamin D during childhood play important roles in ensuring adequate bone mass gain to achieve optimal peak bone mass. The Healthy Immigrant Children study employed a mixed-method cross-sectional study design to characterize the health and nutritional status of 300 immigrant and refugee children aged 3–13 years who had been in Canada for less than 5 years. This paper presents bone mineral content and vitamin D status data along with qualitative data that deepen the understanding of newcomer bone health status. A significantly higher percentage of refugee children (72.3%) had insufficient (<50 nmol/L) or deficient (<30 nmol/L) serum vitamin D compared with immigrants (53.2%). Vitamin D deficiency was most common among ethnic minority girls. Newcomer children with higher intakes of vitamin D, younger newcomer children, and those from western Europe or the United States had higher serum vitamin D levels. Immigrants had significantly higher mean total body bone mineral content compared with refugees. Total body fat, serum vitamin D, calcium intake, height, height by calcium intake, total body fat by calcium intake, and total body fat by height predicted total body bone mineral content levels. Vitamin D deficiency among newcomer children may be related to lack of knowledge regarding children’s vitamin D requirements in the Canadian environment, dietary habits established in country of origin, low income that limits healthy dietary choices, and lifestyle habits that limit exposure to sunlight. Results suggest a need to screen newcomer children and pregnant women for vitamin D deficiency and support early intervention.

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