The experimental study on restraint-induced gastric ulcer—alteration of the microcirculatory system in the gastric wall

1970 ◽  
Vol 5 (1) ◽  
pp. 52-53
Author(s):  
K. Sambe ◽  
M. Tsuchiya ◽  
K. Kamegaya ◽  
T. Shishido ◽  
S. Murai ◽  
...  
Keyword(s):  
Experimental Study ◽  
Gastric Ulcer ◽  
Gastric Wall ◽  
Microcirculatory System

The Effect of Cortisone and Corticotropin on The Healing of Gastric Ulcer: An Experimental Study

1958 ◽  
Vol 34 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Henry D. Janowitz ◽  
Vernon A. Weinstein ◽  
Rhoda G. Shaer ◽  
James F. Cereghini ◽  
Franklin Hollander
Keyword(s):  
Experimental Study ◽  
Gastric Ulcer

Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study

2015 ◽  
Vol 21 (23) ◽  
pp. 3395-3401 ◽  
Author(s):  
Kavita Gulati ◽  
Ayanabha Chakraborti ◽  
Arunabha Ray
Keyword(s):  
Nitric Oxide ◽  
Experimental Study ◽  
Gastric Ulcer ◽  
Ulcer Formation ◽  
Gender Based

scholarly journals Nonhealing Gastric Ulcer Due to Mesh Eroding Through Gastric Wall

2018 ◽  
Vol 16 (8) ◽  
pp. e82-e83
Author(s):  
Ramprasad Jegadeesan ◽  
Tharani Sundararajan ◽  
Scott W. Grisolano
Keyword(s):  
Gastric Ulcer ◽  
Gastric Wall

scholarly journals Gastric Ulcer Perforation with Subsequent Gastric Wall Abscess Mimicking Submucosal Tumor Detected by Endoscopic Ultrasound

2008 ◽  
Vol 16 (1) ◽  
pp. 74-78
Author(s):  
Tsung-Jung Tsai ◽  
Yuan-Horng Yan ◽  
Ching-Hsiu Huang ◽  
Chi-Wen Tu ◽  
Wen-Chuang Wang ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Endoscopic Ultrasound ◽  
Submucosal Tumor ◽  
Gastric Wall ◽  
Ulcer Perforation

scholarly journals EXPERIMENTAL STUDY AND CLINICAL TREATMENT ON THE ACUTE GASTRIC ULCER

1979 ◽  
Vol 12 (7) ◽  
pp. 425-431
Author(s):  
Kazuo NISHIMURA ◽  
Kimiyuki HORI ◽  
Tomoaki URAKAWA ◽  
Masahiko IIMURA ◽  
Yoji UEDA ◽  
...  
Keyword(s):  
Experimental Study ◽  
Gastric Ulcer ◽  
Clinical Treatment

scholarly journals Gastroenteroanastomosis using NOTES-technologies — results of an experimental study

2020 ◽  
Vol 10 (3) ◽  
pp. 275-283
Author(s):  
Aleksandr А. Smirnov ◽  
Alexander V. Chernov ◽  
Asem B. Kargabaeva ◽  
Nadezhda V. Konkina ◽  
Natalya A. Baranova ◽  
...  
Keyword(s):  
Experimental Study ◽  
Histological Analysis ◽  
Single Channel ◽  
Gastric Wall ◽  
Gastrojejunal Anastomosis ◽  
Final Phase ◽  
Laparoscopic Assistance ◽  
Working Out ◽  
Laboratory Models ◽  
Preliminary Phase

Introduction. Transluminal endoscopic surgery performed through natural orifices can reduce the incidence of complications associated with the surgical procedure and the incidence of postoperative complications. The purpose of this study was to determine the feasibility of performing an experimental gastroenteroanastomosis in a live pig model using NOTES. Materials and methods. The experimental study was performed on living laboratory models pigs weighing from 25 to 30 kg. The studys preliminary phase allowed working out the technique using two animals removed from the experiment after its successful completion. The final phase included the implementation of gastrojejunoanastomosis in six animals with subsequent observation. In three animals, the procedure was performed with laparoscopic assistance using a single-channel video gastroscope. In the other three animals, it was performed without laparoscopy using a two-channel video gastroscope. Antibiotic therapy continued for seven days after surgery. The surviving animals were removed from the experiment after four weeks. Patency of the anastomosis was confirmed by repeated endoscopy and histological analysis of tissues. Results. All procedures were completed successfully in six animals (three males and three females). The formation of anastomosis required an average of 133.3 43.8 minutes (range, 80200 minutes). In one animal, bleeding during gastric wall incision was recorded and was stopped by electrocoagulation. One animal died because of an anastomotic leak and peritonitis, confirmed by autopsy. In the five surviving animals, repeated endoscopy demonstrated fully passable anastomoses covered by the mucosa. Conclusion. Gastrojejunal anastomosis using NOTES technology is technically possible but requires additional study.

scholarly journals Effect of Trianthema triquetra Rottl. ex Willed (Aizoaceae) on ethanol-induced gastric ulcers in experimental rats

2021 ◽  
Author(s):  
Hira Ijaz ◽  
◽  
Saiqa Ishtiaq ◽  
Faryal Rubab ◽  
Ans Munir ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Disease Control ◽  
Gastric Wall ◽  
Gastric Volume ◽  
Gastric Ph ◽  
Control Group ◽  
Treated Animal ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug

Trianthema triquetra Rottl. Ex.Willed (T. triquetra) is a medicinal plant that belongs to the family Aizoaceae. The plant has been used traditionally as fodder, as a remedy for chronic ulcer, fever, and healing wounds. Therefore, the present study was intended to investigate the anti-ulcer ability of different fractions of T. triquetra to verify its folklore use in ulcer cure. Acute oral toxicity of all the fractions of T. triquetra was evaluated at a dose of 2g/kg b.wt. Anti-ulcer potential of nbutanol (TTB), chloroform (TTC), ethyl acetate (TTEA) and aqueous (TTA) fraction of crude methanolic extract of T. triquetra was assessed by using ethanol- induced gastric ulcer model in rats. Omeprazole at a dose of 20 mg/kg b.wt. was used as standard drug. After 1 hour of administration of all the fractions of T. triquetra, at a dosage of 300mg/kg b.wt., the gastric ulcer was induced in all animals by administering absolute ethanol (1mL/animal) orally except normal control group. After an hour, all the rats were sacrificed. Ulcer index, % age of ulcer inhibition, gastric pH, gastric volume, total acidity, gastric wall protein, gastric wall mucus and histopathology of the stomach wall of rats were assessed. All fractions of T. triquetra showed a substantial decrease in ulcer index and improvement in percentage inhibition compared to the disease control group. There was a rise in the amount of gastric wall mucus content, total protein content, gastric pH and a decrease in gastric volume and total acidity. Histopathological studies showed severe mucosal injury, leucocyte infiltration and edema in the disease control group compared to omeprazole and plant fractions treated animal groups. The present work encourages the conventional use of T. triquetra in the cure of ulcers.

scholarly journals (-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models

2021 ◽  
Vol 12 ◽  
Author(s):  
Catarina Alves de Lima Serafim ◽  
Maria Elaine Cristina Araruna ◽  
Edvaldo Balbino Alves Júnior ◽  
Leiliane Macena Oliveira Silva ◽  
Alessa Oliveira Silva ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Animal Models ◽  
Gastric Secretion ◽  
Gastric Wall ◽  
Lethal Dose ◽  
Mechanisms Of Action ◽  
Gastric Ulcers ◽  
Ethanol Stress ◽  
Gastroprotective Activity ◽  
Pylorus Ligation

Background: (-)-Carveol (p-Mentha-6,8-dien-2-ol) is a monocyclic monoterpenic alcohol, present in essential oils of plant species such as Cymbopogon giganteus, Illicium pachyphyllum and in spices such as Carum carvi (cumin). Pharmacological studies report its antitumor, antimicrobial, neuroprotective, vasorelaxant, antioxidant and anti-inflammatory activity.Hypothesis/Purpose: The objective of this study was to evaluate the acute non-clinical oral toxicity, gastroprotective activity of monoterpene (-)-Carveol in animal models and the related mechanisms of action.Methods: Acute toxicity was assessed according to OECD guide 423 in mice. Ethanol, stress, NSAIDs and pylorus ligation-induced gastric ulcer models were used to investigate antiulcer properties. The related mechanisms of action were using the ethanol-gastric lesions protocol.Results: (-)-Carveol has low toxicity, with a lethal dose 50% (LD50) equal to or greater than 2,500 mg/kg according to OECD guide nº 423. In all gastric ulcer induction methods evaluated, (-)-Carveol (25, 50, 100 and 200 mg/kg, p.o.) significantly reduced the ulcerative lesion in comparison with the respective control groups. To investigate the mechanisms involved in the gastroprotective activity, the antisecretory or neutralizing of gastric secretion, cytoprotective, antioxidant and immunoregulatory effects were evaluated. In the experimental protocol of pylorus ligation-induced gastric ulcer, (-)-Carveol (100 mg/kg) reduced (p < 0.001) the volume of gastric secretion in both routes (oral and intraduodenal). The previous administration of blockers NEM (sulfhydryl groups blocker), L-NAME (nitric oxide synthesis inhibitor), glibenclamide (KATP channel blocker) and indomethacin (cyclo-oxygenase inhibitor), significantly reduced the gastroprotection exercised by (-)-Carveol, suggesting the participation of these pathways in its gastroprotective activity. In addition, treatment with (-)-Carveol (100 mg/kg) increased (p < 0.001) mucus adhered to the gastric wall. Treatment also increased (p < 0.001) levels of reduced glutathione (GSH), superoxide dismutase (SOD) and interleukin-10 (IL-10). It also reduced (p < 0.001) malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels.Conclusion: Thus, it is possible to infer that (-)-Carveol presents gastroprotective activity related to antisecretory, cytoprotective, antioxidant and immunomodulatory mechanisms.

An Experimental Study of the Gastric Wall Thickness at the Site of Peristalsis in Dogs

Radiology ◽  
1954 ◽  
Vol 62 (4) ◽  
pp. 559-568
Author(s):  
Arthur W. Pryde ◽  
Eugene P. Pendergrass
Keyword(s):  
Experimental Study ◽  
Wall Thickness ◽  
Gastric Wall ◽  
Gastric Wall Thickness
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