scholarly journals Effect of Trianthema triquetra Rottl. ex Willed (Aizoaceae) on ethanol-induced gastric ulcers in experimental rats

2021 ◽  
Author(s):  
Hira Ijaz ◽  
◽  
Saiqa Ishtiaq ◽  
Faryal Rubab ◽  
Ans Munir ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Disease Control ◽  
Gastric Wall ◽  
Gastric Volume ◽  
Gastric Ph ◽  
Control Group ◽  
Treated Animal ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug

Trianthema triquetra Rottl. Ex.Willed (T. triquetra) is a medicinal plant that belongs to the family Aizoaceae. The plant has been used traditionally as fodder, as a remedy for chronic ulcer, fever, and healing wounds. Therefore, the present study was intended to investigate the anti-ulcer ability of different fractions of T. triquetra to verify its folklore use in ulcer cure. Acute oral toxicity of all the fractions of T. triquetra was evaluated at a dose of 2g/kg b.wt. Anti-ulcer potential of nbutanol (TTB), chloroform (TTC), ethyl acetate (TTEA) and aqueous (TTA) fraction of crude methanolic extract of T. triquetra was assessed by using ethanol- induced gastric ulcer model in rats. Omeprazole at a dose of 20 mg/kg b.wt. was used as standard drug. After 1 hour of administration of all the fractions of T. triquetra, at a dosage of 300mg/kg b.wt., the gastric ulcer was induced in all animals by administering absolute ethanol (1mL/animal) orally except normal control group. After an hour, all the rats were sacrificed. Ulcer index, % age of ulcer inhibition, gastric pH, gastric volume, total acidity, gastric wall protein, gastric wall mucus and histopathology of the stomach wall of rats were assessed. All fractions of T. triquetra showed a substantial decrease in ulcer index and improvement in percentage inhibition compared to the disease control group. There was a rise in the amount of gastric wall mucus content, total protein content, gastric pH and a decrease in gastric volume and total acidity. Histopathological studies showed severe mucosal injury, leucocyte infiltration and edema in the disease control group compared to omeprazole and plant fractions treated animal groups. The present work encourages the conventional use of T. triquetra in the cure of ulcers.

Evaluation of Myrtus communis Linn. berries (common myrtle) in experimental ulcer models in rats

2010 ◽  
Vol 29 (11) ◽  
pp. 935-944 ◽  
Author(s):  
Sabiha Sumbul ◽  
Mohd Aftab Ahmad ◽  
Mohd Asif ◽  
Ibne Saud ◽  
Mohd Akhtar
Keyword(s):  
Protective Effect ◽  
Gastric Juice ◽  
Gastric Wall ◽  
Gastric Ph ◽  
Total Acidity ◽  
Myrtus Communis ◽  
Ulcer Index ◽  
Standard Drug ◽  
Methanolic Extracts ◽  
Gastric Juice Volume

The present study was conducted to investigate the protective effect of the dried berries of Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models in Wistar rats. Two doses of aqueous extracts of M. communis (AE 1 and AE2) at the dose 105 and 175 mg/kg, respectively, and methanolic extracts (ME1 and ME2) at the dose of 93 and 154 mg/kg, respectively, were administered orally to animals prior to the exposure of ulcerogens. The parameters taken to assess anti-ulcer activity were ulcer index, gastric juice volume, gastric pH, total acidity, gastric wall mucus and histopathological studies. Oral administration of AE1 and AE2 significantly reduced the ulcer index in all models of ulcers. Low dose of aqueous extract and high dose of methanolic extract of M. communis exhibited more significant effect in comparison to omeprazole (standard drug) in ethanol-induced ulcer model. Both the doses of aqueous and methanolic extracts also reduced the gastric juice volume, total acidity and increased the gastric pH and gastric wall mucus content in all the models of ulcers used in the present study. Histopathological examinations of gastric tissues of rats treated with the aqueous and methanolic extracts in indomethacin-induced ulcer exhibited significant ulcer-protective effect at both the dose levels.

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals GASTROPROTECTIVE EFFECT OF SESBANIA GRANDIFLORA LINN. SEEDS EXTRACT.

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Pallavi. B ◽  
Sunil. N ◽  
Syed Mansoor Ahamed ◽  
Nandheesh R.
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Small Intestine ◽  
World Population ◽  
Total Acidity ◽  
Peptic Ulcers ◽  
Ulcer Index ◽  
Standard Drug ◽  
Sesbania Grandiflora ◽  
Gastroprotective Effect

Background: A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Peptic ulcers are usually aggravated by an imbalance between destructive and defensive factors in the stomach, it affects nearly 10% of world population. The objective of the study was to investigate the protective effect of ethanolic extract of Sesbania grandiflora Linn. Seeds (SGEE) on peptic ulcer induced by ethanol in experimental rats. Objectives: Gastroprotective effect of Sesbania grandiflora Linn. Seeds extract on experimental Materials and Methods: The gastroprotective effect of SGEE was studied using ethanol (70% ) induced acute gastric ulcer models. The animals were divided into five groups, each group contains six animals. SGEE was administered in two doses, (200 mg/kg and 400 mg/kg, p.o). The parameters investigated include acid volume, pH, total acidity, ulcer index, total protein, glutathione, lipid peroxidase, catalase & histopathological studies. Results: 1. In gastroprotective effect study, SGEE significantly inhibited the development of ulcers induced by ethanol. The SGEE significantly reduced the acid volume, total acidity, total acidity, ulcer index, lipid peroxidation & increases in pH, glutathione & catalase level. Histopathogical studies also revealed that SGEE is gastro-protective. Ranitidine (100 mg/kg) is used as standard drug. Conclusion: All the observation implies that SGEE possess significant protective activity against ethanol induced gastric ulcer in experimental rats. 400 mg/kg doses has shown more protection compared to 200 mg/kg (dose dependent activity was obtained). Keywords: Antiulcer; Sesbania grandiflora; Ethanol; Ranitidine.

scholarly journals Evaluation of Anti-Ulcer Activity of Garcinia cambogia in Experimentally Induced Ulcer in Rats

2021 ◽  
pp. 18-25
Author(s):  
G. P. Sharook ◽  
Prasanna Shama Khandige ◽  
K. C. Bharath Raj
Keyword(s):  
Ethanolic Extract ◽  
Gastric Ph ◽  
Control Group ◽  
Total Acidity ◽  
Free Acidity ◽  
Oral Toxicity ◽  
Ulcer Index ◽  
Garcinia Cambogia ◽  
Ulcerogenic Activity ◽  
Experimentally Induced

Peptic ulcer is the most common gastrointestinal disorder that world faces at present. Garcinia cambogia is one of the folk plants used by the people to treat various ailments to attain health benefits.  Every part of the plant has various activities which can eradicate maximum health issues. The present study is aimed to investigate the gastro-protective and anti-ulcerogenic activity of ethanolic extract of Garcinia cambogia. The ethanolic extract was tested orally in doses of 200 mg/kg and 400mg/kg which was obtained from the acute oral toxicity studies on gastric ulcerations experimentally induced by pylorus ligation and ethanol in rats. Comparison of the drug effect is done with the effect of standard drugs, omeprazole (30 mg/kg) and sucralfate (100 mg/kg). The parameters like gastric pH, gastric acid volume, total acidity, free acidity and ulcer index are assessed.The ethanolic extract showed an activity in a dose of 200 mg/kg and 400 mg/kg with a reduction in the gastric volume, total acidity, free acidity, ulcer index and raise in the gastric pH when compared to that of ulcer control group. A gastro-protective and anti-ulcerogenic activity is shown by the extract of Garcinia cambogia both in ethanol induced ulcer model and pylorus ligated ulcer model.At the concluding point, extract of Garcinia cambogia was found to possess a very good gastroprotective and anti-ulcerogenic property. The results of the study revealed the further uses of the leaves of this plant in the treatment of ulcers in the stomach.

scholarly journals Antiulcerogenic effect of Methanolic Root Extract of Berberis lycium Linn by Pylorus ligation and Ethanol induced Ulceration

2021 ◽  
Vol 11 (4-S) ◽  
pp. 9-14
Author(s):  
Priyanka Namdeo ◽  
Madhuri Pandole ◽  
Priti Singh
Keyword(s):  
Gastric Volume ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Root Extract ◽  
Total Acidity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Pylorus Ligation ◽  
Berberis Lycium

Background: Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. The present study was carried out to evaluate the antiulcer activity of the methanolic root extract of Berberis lycium in albino rats. Method: The methanolic root extract of Berberis lycium was prepared by hot extraction method. Anti-ulcer activity was evaluated and method employed was pylorus ligation and ethanol induced in albino rats. Preliminary methanolic extract of Berberis lycium was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Animals were divided into four groups of six animals each. The animals of Group I served as normal control (vehicle) which received distilled water. Group II and III received 250 mg/kg and 500 mg/kg of methanolic root extract, respectively. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. Group IV received Ranitidine at 50 mg/kg was used as the standard drug. Pretreatment of methanol root extract of Berberis lycium showed significant (P˂0.05) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly increased only at higher dose 500 mg/kg. It showed also significant (P˂0.05) decrease in number of ulcers and ulcer score index in pylorus ligation and ethanol induced ulceration models. Results: The methanol root extract of Berberis lycium showed a significant reduction in the total acidity, free acidity and acid volume. The efficacy of plant extract at high dose was comparable with the standard drug Ranitidine. Conclusion: Our study results support the ethnomedical use of root of Berberis lycium. Keywords: Antiulcer activity, Berberis lycium, Pylorus ligation, Ranitidine, Ulcer Index.

scholarly journals Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Harikesh Maurya ◽  
Monika Semwal ◽  
Susheel Kumar Dubey
Keyword(s):  
Wound Healing ◽  
Disease Control ◽  
Povidone Iodine ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Elevated Blood Glucose Level ◽  
Pharmacological Potential

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.

GASTRO-PROTECTIVE POTENTIAL OF FLOWERS OF HIBISCUS ROSA-SINENSIS (L.) IN MUCOSAL LESION ON RATS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 25-31
Author(s):  
K. K Agrawal ◽  
A. Verma ◽  
K Singh ◽  
Keyword(s):  
Wistar Rats ◽  
Gastric Volume ◽  
Control Group ◽  
Phytochemical Screening ◽  
Protective Activity ◽  
Ulcer Index ◽  
Hibiscus Rosa Sinensis ◽  
Pylorus Ligation ◽  
Ethanolic Extracts ◽  
Ulcer Model

study was conducted to evaluate the gastro-protective activity of aqueous (HAE) and ethanolic (HEE) extracts of Hibiscus rosa-sinensis Linn. (Malvaceae) flowers in experimental animals. Aqueous and ethanolic extracts were investigated for pylorus ligation and indomethacin induced ulcer models in albino wistar rats. The pH, gastric volume, ulcer index, ulcer score and free and total acidity were determined by pylorus ligation induced ulcer model and ulcer score, ulcer index and percentage protection were determined by Indomethacin induced ulcer model. Phytochemical screening of aqueous and ethanolic extracts were conducted for and it showed that extracts have alkaloids, glycosides, tannins, flavonoids and mucilage. Both the extracts at dose of 200 and 400mg/kg showed significant (P<0.05) reduction in gastric volume (1.20±0.17, 0.83±0.20, 0.90±0.12, 0.96±0.17) and ulcer index (1.50±0.19, 1.33±0.11, 2.16±0.03, 0.75±0.17, 0.92±0.22, 0.31±0.04, 0.42±0.06, 0.19±0.04) as compared to the control group (1.47±0.15, 3.00±0.21, 1.64±0.13) in both of the models. It can be concluded that both the extracts possess gastro-protective activity that might be due the presence of flavanoids, tannins and/or mucilage.

scholarly journals Gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana on aspirin and histamine-induced gastric ulcer in rats

2020 ◽  
Vol 8 (1) ◽  
pp. 70
Author(s):  
Ibrahim Abubakar ◽  
Hassan Muhammad Yankuzo ◽  
Yusha'u Shuaibu Baraya ◽  
Mu'azu Abubakar Gusau
Keyword(s):  
Protective Effect ◽  
Ph Value ◽  
Gastrointestinal Diseases ◽  
Gastric Volume ◽  
Total Acidity ◽  
Gastric Lesions ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Gastroprotective Effect ◽  
Ulcer Model

Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.   

scholarly journals Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Oche Okpe ◽  
Nathan Habila ◽  
Joseph Ikwebe ◽  
Vincent A. Upev ◽  
Stanley I. R. Okoduwa ◽  
...  
Keyword(s):  
Disease Control ◽  
Plasmodium Berghei ◽  
Carica Papaya ◽  
Synergistic Effects ◽  
Hematological Parameters ◽  
Parasite Load ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Standard Drug ◽  
Change In Mean

The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each. Group 1 was normal control, while groups 2–6 were intraperitoneally inoculated 2.5 × 107 Plasmodium berghei parasitized red blood cell, followed by daily administration of 350 mg/kg aqueous leaf extracts after establishment of infection. Group 2 was disease control, while group 6 was treated with standard drug for four consecutive days. The results showed significant (P<0.05) reduction in percentage of parasite load between the infected treatment groups and disease control group at day 3 after infection, which remained consistent until the end of the experiment. All infected treated groups showed significant (P<0.05) increases in RBC and PCV recovery compared to the disease control, with the exception of WBC. There was insignificant (P>0.05) change in mean body weight of all treated groups except in disease control group. Histological studies of the infected mice indicate recovery of hepatic cells from congested black pigmentation. The reduction in parasite load and recovery of hepatic cell damage/hematological parameters were induced by these plant extracts. This highlighted the important usage of the plant in traditional remedy of malaria infection.

scholarly journals Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats

2021 ◽  
Vol 9 (5) ◽  
pp. 1412
Author(s):  
Rupali V. Jadhav ◽  
V. K. Redasani ◽  
Shankar B. Kalbhare ◽  
Karishma Yadav ◽  
Aryan Langeh ◽  
...  
Keyword(s):  
Low Dose ◽  
Positive Control ◽  
Gastric Volume ◽  
Control Group ◽  
High Dose ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
The Impact ◽  
Intermediate Dose

Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significant decrease in gastric volume, significant decrease in ulcer index and significant decrease in total acidity.Conclusions: The impact of 4-HBD therapy with intermediate (100mg/kg, p.o.) dose was observed to be similar with the positive control group.  

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