Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study

Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

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Central basic fibroblast growth factor inhibits gastric ulcer formation and gastric emptying in rats

Journal of the Autonomic Nervous System ◽

10.1016/0165-1838(92)90112-t ◽

1992 ◽

Vol 41 (3) ◽

pp. 248-249

Author(s):

Toshikatsu Okumura ◽

Akira Uehara ◽

Shigeru Kitamori ◽

Yoshiaki Taniguchi ◽

Yasuo Watanabe ◽

...

Keyword(s):

Gastric Ulcer ◽

Gastric Emptying ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Basic Fibroblast Growth Factor ◽

Ulcer Formation ◽

Fibroblast Growth

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The effect of locally administered prostaglandin 15 (R) 15 methyl-E2 methyl ester on gastric ulcer formation in the shay rat preparation

Prostaglandins ◽

10.1016/s0090-6980(74)80015-8 ◽

1974 ◽

Vol 5 (5) ◽

pp. 455-462 ◽

Cited By ~ 22

Author(s):

D.C. Carter ◽

P.A. Ganesan ◽

D. Bhana ◽

S.M.M. Karim

Keyword(s):

Gastric Ulcer ◽

Methyl Ester ◽

Ulcer Formation

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Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

IMC Journal of Medical Science ◽

10.3329/imcjms.v12i1.35171 ◽

2018 ◽

Vol 12 (1) ◽

pp. 11-14

Author(s):

Sharmin Rahman ◽

Mohammad Rezaul Quader ◽

Md Ismail Khan

Keyword(s):

Body Weight ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Aqueous Extract ◽

Protective Efficacy ◽

Albino Rats ◽

Ulcer Formation ◽

Aegle Marmelos ◽

Rat Stomach ◽

Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

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Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v12i2.29980 ◽

2017 ◽

Vol 12 (2) ◽

pp. 11

Author(s):

Zaman Hayat ◽

Mueen Ahmad Chaudhry ◽

. Alamgeer

Keyword(s):

Peptic Ulcer ◽

Gastric Ulcer ◽

Treated Group ◽

Ulcer Formation ◽

Ulcer Index ◽

Herbal Formulation ◽

High K ◽

Ulcer Model ◽

Dose Dependent ◽

Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p<0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

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