Synthesis of O,O-dialkyl-S-[benzoyl-(benzylidene amino)] dithiophosphorates and their inhibitory effect on acetyl-cholinesterase activity

1981 ◽  
Vol 90 (1) ◽  
pp. 69-75
Author(s):  
J. S. Shukla ◽  
Renu Rastogi
Keyword(s):  
Cholinesterase Activity ◽  
Inhibitory Effect ◽  
Acetyl Cholinesterase

STUDY OF ACETYL CHOLINESTERASE ACTIVITY IN FORAGER WORKER BEES OF APIS MELLIFERA UNDER STRESS OF PESTICIDES

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
SUSHIL KUMAR
Keyword(s):  
Apis Mellifera ◽  
Ache Activity ◽  
Cholinesterase Activity ◽  
Inhibitory Effect ◽  
Neem Oil ◽  
Acetyl Cholinesterase ◽  
Specific Activities ◽  
Sublethal Concentrations

The effect of sublethal concentrations 1/8 and 1/4 of LC50 at 24 h of five pesticides including three organophosphates, Dimethoate, Malathion and Quinalphos, one neonicotinoid Acetamiprid and one biopesticide Neem oil on acetylcholinesterase (AChE) activity in forager bees of Apis mellifera was studied. The specific activities of acetylcholinesterase (AChE) were measured in head and thorax of surviving foragers after 24 h of treatment. The data revealed that all the pesticides suppressed the AChE activity but organophosphates had more inhibitory effect on AChE activity as compared to neonicotinoid Acetamiprid. Among organophosphates Dimethoate proved to be most toxic at sublethal concentrations followed by Malathion, Quinalphos and acetamiprid. Significant changes were observed at 1/4 of LC50 at 24 hrs but did not have so well defined inhibitory effect at 1/8 of LC50 at 24 h Neem oil was found to be nontoxic.

scholarly journals Neurobehavioral responses of the freshwater teleost, Cyprinus carpio (Linnaeus.) under quinalphos intoxication

2009 ◽  
Vol 25 (3-4) ◽  
pp. 241-249 ◽  
Author(s):  
S.G. Chebbi ◽  
M. David
Keyword(s):  
Cyprinus Carpio ◽  
Cholinesterase Activity ◽  
Morphological Changes ◽  
Inhibitory Effect ◽  
Behavioral Changes ◽  
Control Group ◽  
Cholinergic Transmission ◽  
Acetyl Cholinesterase ◽  
Freshwater Teleost ◽  
Exposed Fish

Effect of quinalphos on the freshwater fish, Cyprinus carpio to elucidate inhibitory effect of quinalphos on acetyl cholinesterase activity associated behavioral changes. Fishes were exposed to one fifth (0.15 ?g/l) and one tenth (0.75 ?g/l) of the lethal concentration (7.5 ?g/l) of quinalphos for a period of 1, 7 and 14 days, and were allowed to recover for 7 days. Maximum decrement in acetyl cholinesterase activity of the exposed fish was recorded in brain followed by muscle, gill and liver. Recovery tenures witnessed increment in acetyl cholinesterase activity but significantly differed in comparison with control group. Depression of acetyl cholinesterase activity suggests decreased cholinergic transmission and consequent accumulation of acetylcholine in the tissues leading to cessation of nerve impulses. This has lead to behavioral and morphological changes due to impaired neurophysiology of the fish. .

scholarly journals EFFECT OF ROTATORY VESTIBULAR STIMULATION ON LEARNING AND MEMORY IN RATS-STANDARDIZATION OF A NOVEL METHOD

2016 ◽  
Vol 9 (1) ◽  
pp. 145 ◽  
Author(s):  
Devi N. P. ◽  
J. K. Mukkadan
Keyword(s):  
Learning And Memory ◽  
Cholinesterase Activity ◽  
Vestibular Stimulation ◽  
Dendritic Arborization ◽  
Acetyl Cholinesterase ◽  
Standard Drug ◽  
Behavioural Analysis ◽  
Behavioural Patterns ◽  
Biochemical Studies ◽  
Novel Method

<p><strong>Objective</strong>:<strong> </strong>To find out the effect of rotatory vestibular stimulation in cognition in rats through examining the behavioural patterns, the alterations in dendritic arborization and changes in AChE activity.</p><p><strong>Methods</strong>:<strong> </strong>Rotatory vestibular stimulation was provided in a rotatory vestibular apparatus at a rate of 50 rpm for 5 min, for 30 d for rats. 0.3 mg/kg of physostigmine also administered to rats of another group as a standard drug. No rotatory vestibular stimulation or physostigmine is provided to the control rats. Behavioural analysis, Neuromorphological and biochemical studies were done after vestibular stimulation.</p><p><strong>Results</strong>:<strong> </strong>No. of trails for acquisition and retention reduced significantly in treated rats when compared with the control rats. In all the treated rats the dendritic arborization increased significantly, and activity of AChE decreased significantly when compare with the control.</p><p><strong>Conclusion</strong>:<strong> </strong>Rotatory vestibular stimulation enhances learning and memory <em>via</em> increasing dendritic arborization and inhibiting acetyl-cholinesterase activity in rats. </p>

Bioassay-Guided Isolation and Identification of a Acetylcholinesterase Inhibitors from Calophyllum polyanthum

2013 ◽  
Vol 634-638 ◽  
pp. 1225-1228 ◽  
Author(s):  
Fei Zhang ◽  
Hai Wei Ren ◽  
Yong Gang Wang ◽  
Rong Wang ◽  
Jie Sheng
Keyword(s):  
Inhibitory Activity ◽  
Cholinesterase Activity ◽  
Spectral Characteristics ◽  
Ethanolic Extract ◽  
Acetylcholinesterase Inhibitors ◽  
Microplate Assay ◽  
Acetyl Cholinesterase ◽  
Isolation And Identification ◽  
Active Compounds ◽  
Bioautographic Method

A significant acetylcholinesterase inhibitory activity was observed for the Ethanolic extract from the leaves of Calophyllum polyanthum by using TLC bioautographic method. Further bioassay-guided isolation of this extract using TLC bioautographic method resulted in obtaining a pyranochromanone, apetalic acid (1). The structure of 1 was identified by comparison of it’s spectral characteristics with previous reports. The concentration required for 50% inhibition of 1 was 0.95 mM, determined by a microplate assay. The anti-acetylcholinesterase aity of compound 1 was weak, but it was the first pyranochromanone which have anti-acetyl cholinesterase activity. As a new leading compound, it can be modified and transformed to obtain more potently active compounds.

scholarly journals In Vitro and In Silico Antioxidant, Anti-Diabetic, Anti-HIV and Anti-Alzheimer Activity of Endophytic Fungi, Cladosporium uredinicola Phytochemicals

2019 ◽  
Vol 13 ◽  
pp. 13-34
Author(s):  
Melappa Govindappa ◽  
V. Thanuja ◽  
S. Tejashree ◽  
C.A. Soukhya ◽  
Suresh Barge ◽  
...  
Keyword(s):  
Qualitative Method ◽  
Cholinesterase Activity ◽  
Methanol Extract ◽  
High Binding Energy ◽  
Acetyl Cholinesterase ◽  
Gp 120 ◽  
Anti Hiv ◽  
Hiv 1

The present work was aimed to identify phytochemicals in C. uredinicola methanol extract from qualitative, TLC and GC-MS method and evaluated for antioxidant, anti-HIV, anti-diabetes, anti-cholinesterase activity in vitro and in silico. The C. uredinicola extract showed flavonoids, tannins, alkaloids, glycosides, phenols, terpenoids, and coumarins presence in qualitative method. From GC-MS analysis, identified seven different phytochemicals and out of seven, four (coumarin, coumarilic acid, hymecromone, alloisoimperatorin) are coumarins. The C. uredinicola extract have shown significant antioxidant activity in DPPH (73) and FRAP (1359) method. The HIV-1 RT (83.81+2.14), gp 120 (80.24+2.31), integrase (79.43+3.14) and protease (77.63+2.14), DPPIV, β-glucosidase and acetyl cholinesterase activity was significantly reduced by the extract. The 2-diphenylmethyleneamino methyl ester had shown significant interaction with oxidant and HIV-1 proteins whereas alloisoimperatorin have interacted with diabetes and cholinesterase proteins followed by hymecromone with high binding energy. These three phytochemicals are non-carcinogens, non-toxic, readily degradable and have drug likeliness properties. The C. uredinicola phytochemicals are responsible for management of diabetes, HIV-1 and Alzheimer. Further in vivo work is needed to justify our research.

scholarly journals Acetyl-cholinesterase Enzyme Inhibitory Effect of Calophyllum species

2015 ◽  
Vol 14 (11) ◽  
pp. 2005
Author(s):  
Gwendoline Cheng Lian Ee ◽  
Soek Sin Teh ◽  
Siau Hui Mah ◽  
Nur Ain Jamaluddin ◽  
Muhamad Syarik bin Muhamad Sahimi ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Acetyl Cholinesterase
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