Multivariate regression analysis of prognostic factors in colorectal cancer

2003 ◽  
Vol 2 (3) ◽  
pp. 149-152 ◽  
Author(s):  
Yang Zuli ◽  
Wang Jianping ◽  
Wang Lei ◽  
Dong Wenguang ◽  
Huang Yihua ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Analysis ◽  
Prognostic Factors ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis

scholarly journals Inflammatory Biomarkers May Predict Poor Outcome in Patients with Chronic Cerebrospinal Venous Insufficiency.

2020 ◽  
Author(s):  
Siying Song ◽  
Duo Lan ◽  
Xiao qin Wu ◽  
Yu chuan Ding ◽  
Xun ming Ji ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Prognostic Factors ◽  
Multivariate Regression ◽  
Venous Insufficiency ◽  
Multivariate Regression Analysis ◽  
Inflammatory Biomarkers ◽  
Lymphocyte Ratio ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Poor Outcome ◽  
Inflammatory State

Abstract Background and purpose Chronic cerebrospinal venous insufficiency (CCSVI) related inflammatory process is still unclear. This study aimed to evaluate peripheral inflammatory biomarkers in both intracranial CCSVI and the extracranial CCSVI group, as well as the relationship between the inflammatory state and prognosis of CCSVI.Methods Patients with CCSVI were included from July 2017 to July 2019, divided into three groups by location of stenosis. The inflammatory biomarker assay included neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red blood cell distribution width (RDW), C-reactive protein (CRP), interleukin- 6 (IL-6)) and neuron-specific enolase (NSE). The clinical outcome was assessed by the modified Rankin Scale (mRS) and Patient Global Impression of Change (PGIC) score. Univariate and multivariate regression analysis was performed to identify significant prognostic factors for poor outcome. Then a nomogram based on multivariate regression analysis was established.Results In total, 248 consecutive patients were enrolled, 102 males and 146 females, with an average age of 57.85 ± 12.28 years. Patients with cerebral venous sinus stenosis (CVSS) were more likely to be younger age and present headaches and severe papilledema. Higher levels of NLR, RDW, and CRP were also observed in the CVSS group. In multivariate analysis, NLR, PLR, and IL-6 became the independent prognostic factors for predicting the poor outcome of CCSVI.Conclusions The clinical presentations and the increased levels of NLR, PLR, and CRP may be more remarkable in the group with CVSS-related CCSVI than that with internal jugular venous stenosis (IJVS)-related CCSVI. The pro-inflammatory state may relate to CCSVI. An elevated level of NLR, PLR, and IL-6 played a negative role in the prognosis of CCSVI.

Prognostic factors in Waldenström's macroglobulinemia: a report of 167 cases.

1993 ◽  
Vol 11 (8) ◽  
pp. 1553-1558 ◽  
Author(s):  
T Facon ◽  
M Brouillard ◽  
A Duhamel ◽  
P Morel ◽  
M Simon ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Prognostic Factors ◽  
Multivariate Regression ◽  
Prognostic Value ◽  
Multivariate Regression Analysis ◽  
Lymphoid Cells ◽  
Waldenström’S Macroglobulinemia ◽  
Male Sex ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

PURPOSE A single-center retrospective analysis was conducted in 167 patients with Waldenström's macroglobulinemia (WM) to delineate prognostic factors. PATIENTS AND METHODS One hundred sixty-seven patients diagnosed between January 1969 and December 1988, fulfilling diagnostic criteria of WM, were entered onto this study. One hundred twenty-eight patients were treated with chlorambucil (0.1 mg/kg/d): 117 at diagnosis and 11 during the disease course. Seventeen variables were analyzed in all patients and in treated patients for their prognostic value on survival using the Kaplan-Meier method and a Cox multivariate regression analysis. RESULTS Median survival duration for all patients was 60 months. Pretreatment factors associated with shorter survival in the entire population were age > or = 60 years (P = .006), male sex (P = .0001), general symptoms (P = .01), hemoglobin less than 10 g/dL (P = .008), leukocytes less than 4 X 10(9)/L (P = .02), neutrophils less than 1.7 X 10(9)/L (P = .02), and platelets less than 150 X 10(9)/L (P = .0006). Organomegaly, signs of hyperviscosity, renal failure, monoclonal immunoglobulin M (M IgM) level, blood lymphocytosis, and percentage of marrow lymphoid cells were not significantly correlated with survival. In a Cox multivariate regression analysis, the combination of factors that gave the best prognostic value was the association of sex (P = .0002), neutrophils (P = .002), age (P = .008), and hemoglobin (P = .02). CONCLUSION Our findings suggest that some pretreatment parameters, including older age, male sex, general symptoms, and cytopenias, carry a poor prognosis in WM. By contrast, high initial tumor burden (indicated by organomegaly, high IgM level, and high percentage of marrow lymphoid cells) does not seem to be significantly associated with short survival. Our results help define a high-risk population that could perhaps benefit from newer therapeutic approaches.

Possible predictive clinical factors for chemotherapy holiday in metastatic colorectal cancer: A single institution–based retrospective data analysis.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 720-720
Author(s):  
Praveen Kumar Tumula ◽  
Umit Tapan ◽  
Kevan L. Hartshorn
Keyword(s):  
Colorectal Cancer ◽  
Regression Analysis ◽  
Metastatic Colorectal Cancer ◽  
Multivariate Regression ◽  
Strong Predictor ◽  
Performance Status ◽  
Retrospective Chart Review ◽  
Complete Response ◽  
Multivariate Regression Analysis ◽  
Metastatic Colon Cancer

720 Background: During the last decade, numerous new agents were introduced into the therapy of metastatic colorectal cancer. For those patients who are not curable by resection, life can be extended with chemotherapy. However, it is not possible to predict who can safely take breaks without compromising survival. We sought to evaluate the relationship between various possible predictive factors and the duration of break from chemotherapy in patients with metastatic colorectal cancer. Methods: The hospital’s cancer registry was used to identify metastatic colon cancer cases diagnosed from January 2008 to December 2012. To be included in the study, the patient must have been diagnosed with colorectal adenocarcinoma, treated with a fluoropyrimidine based chemotherapy regimen and had planned treatment breaks. Retrospective chart review of electronic medical records was used to collect patient characteristics, including age, performance status (ECOG), comorbidities, disease burden (number of metastasis), and response to the initial treatment. Multivariate regression analysis was performed to observe impact of various variables on the duration of break from chemotherapy. Results: A total of 110 patients were diagnosed with metastatic colorectal cancer between 2008 to 2012 and 27 (24.5%) subjects in the initial analysis met the inclusion criteria, with a mean age of 56 years. The percentage of male and female patients was 37% and 63%, respectively. Patients who had a complete response to the initial chemotherapy (n=6) had 69±23 week breaks which was significantly longer (p<0.01) than the 17±2 and 13±5 week breaks of those with partial response or stable disease. In multivariate regression analysis, degree of response was a significant predictor for chemotherapy breaks (CI 0.36 – 1.77, p=0.005). No statistical difference was noted in other variables. Conclusions: These preliminary findings suggest that complete response to initial chemotherapy may be a strong predictor of patients who can safely undergo chemotherapy breaks. This study also raises the possibility that various factors could influence break from chemotherapy.

scholarly journals Clinical and prognostic factors in 98 patients with malignant melanoma in China

2017 ◽  
Vol 45 (4) ◽  
pp. 1369-1377 ◽  
Author(s):  
Min Zhang ◽  
Nan Zhang
Keyword(s):  
Regression Analysis ◽  
Prognostic Factors ◽  
Malignant Melanoma ◽  
Multivariate Regression ◽  
Clinical Stage ◽  
Survival Rates ◽  
Surgical Excision ◽  
Multivariate Regression Analysis ◽  
Exact Probability ◽  
Independent Risk Factors

Objective To investigate clinical and prognostic factors in patients with malignant melanoma (MM) in China. Methods A total of 98 MM patients were enrolled in the study. Enumeration data were analyzed using Fisher’s exact probability tests or χ2 tests. Survival rates were calculated using log-rank tests. A Cox multivariate regression analysis was performed to determine independent prognostic factors. Results The male: female incidence ratio was 1.88:1. The highest incidence rate was seen in the 45–65 year age group. Primary lesion ulceration was seen in 60.2% of patients. The 1-year, 3-year and 5-year survival rates were 85.7%, 34.7% and 13.3%, respectively. In univariate analyses, the 5-year survival rate in patients was significantly associated with ulceration (P < 0.01), clinical stage (P < 0.01) and surgical excision of the tumor (P < 0.01). Cox multivariate regression analysis confirmed that ulceration and clinical stage were independent prognostic factors. Conclusions Some clinical characteristics of MM patients in China are significantly different from those of patients in Western countries. Ulceration and clinical stage are independent risk factors for poor survival in MM patients.

scholarly journals Does Colonic Diverticulosis Raise the Risk of Colorectal Adenoma in Patients with Colorectal Cancer?

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Yeon-Ji Kim ◽  
Dae Bum Kim ◽  
Woo Chul Chung ◽  
Ji Min Lee
Keyword(s):  
Colorectal Cancer ◽  
Regression Analysis ◽  
Multivariate Regression ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Regression Analysis ◽  
Colorectal Adenomas ◽  
Multivariate Logistic Regression ◽  
Colonic Diverticulosis ◽  
Increased Risk

Background. The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods. We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative colonoscopic and barium enema examinations. Follow-up colonoscopic examinations were performed within 1 year and between 3 and 5 years postoperatively. The incidence of colorectal adenomas was compared based on the presence or absence of diverticulosis. Additionally, multivariate logistic regression analysis was performed to identify the factors independently associated with the development of synchronous and metachronous colorectal adenomas. Results. Of the 168 patients with CRC included in the study, 55 showed colonic diverticulosis. Synchronous colorectal adenomas were more common in CRC patients with diverticulosis than in those without diverticulosis (P>0.001). Multivariate regression analysis showed that colonic diverticulosis (odds ratio (OR) 3.874, 95% confidence interval (CI) 1.843–8.144, P>0.001) and obesity (body mass index>25.0 kg/m2, OR 2.395, 95% CI 1.089–5.270, P=0.030) were associated with an increased risk of synchronous colorectal adenomas. The presence of synchronous colorectal adenomas increased the risk of metachronous colorectal adenomas (OR 4.407, 95% CI 1.855–10.473, P>0.001). Conclusions. Colonic diverticulosis was associated with synchronous colorectal adenomas in patients with CRC, which is eventually increasing the risk of metachronous adenomas.

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