Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of akt

2004 ◽  
Vol 27 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Sang Ho Choi ◽  
Su Yun Lyu ◽  
Won Bong Park
2020 ◽  
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pp. 407-425
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Irmina Diala ◽  
Yasuo Shiohama ◽  
Takashi Fujita ◽  
Yojiro Kotake ◽  
Constantinos Demonacos ◽  
...  

2007 ◽  
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Lee-Yong Khil ◽  
Wi Kim ◽  
Suyun Lyu ◽  
Won Bong Park ◽  
Ji-Won Yoon ◽  
...  

Lung Cancer ◽  
2010 ◽  
Vol 68 (3) ◽  
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Julia Beisner ◽  
Meng Dong ◽  
Sebastian Taetz ◽  
Noha Nafee ◽  
Ernst-Ulrich Griese ◽  
...  

2019 ◽  
Vol 42 (6) ◽  
pp. 906-914 ◽  
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Ratasark Summart ◽  
Ariyaphong Wongnoppavich ◽  
Bannakij Lojanapiwat ◽  
T. Randall Lee ◽  
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Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S84
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Stefan Zimmermann ◽  
Andreas Schnapp ◽  
Klaus Damm ◽  
Uwe M. Martens

2011 ◽  
Vol 22 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Marie Eve Brault ◽  
Chantal Autexier

 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after telomerase inhibition. We determined whether telomeric recombination can also be promoted by telomere dysfunction. We report for the first time that telomeric recombination can be induced in human telomerase-positive cancer cells with dysfunctional telomeres.


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