Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of akt

2004 ◽  
Vol 27 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Sang Ho Choi ◽  
Su Yun Lyu ◽  
Won Bong Park
Keyword(s):  
Cancer Cells ◽  
Mistletoe Lectin ◽  
Telomerase Inhibition

scholarly journals Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT

2020 ◽  
Vol 39 (1-3) ◽  
pp. 407-425
Author(s):  
Irmina Diala ◽  
Yasuo Shiohama ◽  
Takashi Fujita ◽  
Yojiro Kotake ◽  
Constantinos Demonacos ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Telomerase Inhibition ◽  
Telomere Attrition

scholarly journals Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells

2007 ◽  
Vol 13 (20) ◽  
pp. 2811 ◽  
Author(s):  
Lee-Yong Khil ◽  
Wi Kim ◽  
Suyun Lyu ◽  
Won Bong Park ◽  
Ji-Won Yoon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mistletoe Lectin ◽  
Korean Mistletoe ◽  
Induced Apoptosis

Nanoparticle mediated delivery of 2′-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells

Lung Cancer ◽  
2010 ◽  
Vol 68 (3) ◽  
pp. 346-354 ◽  
Author(s):  
Julia Beisner ◽  
Meng Dong ◽  
Sebastian Taetz ◽  
Noha Nafee ◽  
Ernst-Ulrich Griese ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Telomere Shortening ◽  
Telomerase Inhibition ◽  
Human Lung Cancer Cells

scholarly journals Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells

2019 ◽  
Vol 42 (6) ◽  
pp. 906-914 ◽  
Author(s):  
Navakoon Kaewtunjai ◽  
Ratasark Summart ◽  
Ariyaphong Wongnoppavich ◽  
Bannakij Lojanapiwat ◽  
T. Randall Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Prostate Cancer Cells ◽  
Telomere Shortening ◽  
Telomerase Inhibition ◽  
Perylene Derivatives

O-289 Telomerase inhibition leads to telomere dysfunction and consecutive growth arrest in lung cancer cells

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S84
Author(s):  
Milena Pantic ◽  
Stefan Zimmermann ◽  
Andreas Schnapp ◽  
Klaus Damm ◽  
Uwe M. Martens
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Lung Cancer Cells ◽  
Telomere Dysfunction ◽  
Telomerase Inhibition

scholarly journals Telomeric recombination induced by dysfunctional telomeres

2011 ◽  
Vol 22 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Marie Eve Brault ◽  
Chantal Autexier
Keyword(s):  
Cancer Cells ◽  
Telomere Maintenance ◽  
Telomere Dysfunction ◽  
Telomerase Inhibition ◽  
Human Telomerase ◽  
First Time ◽  
Cellular Immortality

 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after telomerase inhibition. We determined whether telomeric recombination can also be promoted by telomere dysfunction. We report for the first time that telomeric recombination can be induced in human telomerase-positive cancer cells with dysfunctional telomeres.

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