Failure to Detect Epstein-Barr Virus (EBV) DNA in Plasma by Real-Time PCR in a Case of EBV-Associated Posttransplantation Lymphoproliferative Disorder Confined to the Central Nervous System

2002 ◽  
Vol 75 (4) ◽  
pp. 416-420 ◽  
Author(s):  
Teruhiko Terasawa ◽  
Haruhiko Ohashi ◽  
Keitaro Tsushita ◽  
Makoto Utsumi ◽  
Eiichiro Mukai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Real Time Pcr ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Posttransplantation Lymphoproliferative Disorder

scholarly journals Epstein–Barr Virus-Induced Post-Transplant Lymphoproliferative Disorder of the Central Nervous System Successfully Treated with Chemo-Immunotherapy

Viruses ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 416
Author(s):  
Hiroaki Inoue ◽  
Shinya Rai ◽  
Hirokazu Tanaka ◽  
J. Luis Espinoza ◽  
Maiko Komori-Inoue ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aplastic Anemia ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Hematopoietic Stem ◽  
Post Transplant ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Epstein Barr

Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals with a donor available, can be successfully treated with hematopoietic stem cell transplantation (HSCT). We report here a rare case of post-transplant lymphoproliferative disorder (PTLD) associated with Epstein–Barr virus (EBV) reactivation in a 30-year-old female patient who underwent allogeneic HSCT for severe aplastic anemia. The PTLD, which was diagnosed 230 days after transplantation, was localized exclusively in the central nervous system (specifically in the choroid plexus) and manifested with obvious signs of intracranial hypertension. After receiving three cycles of high dose methotrexate (HD-MTX) combined with rituximab, the patient achieved a complete clinical recovery with normalization of blood cell counts, no evidence of EBV reactivation, and no associated neurotoxicity.

Infection with Two Genotypes of Epstein-Barr Virus in an Infant with AIDS and Lymphoma of the Central Nervous System

1986 ◽  
Vol 153 (3) ◽  
pp. 601-604 ◽  
Author(s):  
B. Z. Katz ◽  
W. A. Andiman ◽  
R. Eastman ◽  
K. Martin ◽  
G. Miller
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Epstein Barr
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