Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes

2009 ◽  
Vol 32 (5) ◽  
pp. 454-259 ◽  
Author(s):  
X. D. Wan ◽  
W. B. Yang ◽  
Y. Z. Xia ◽  
J. F. Wang ◽  
T. Lu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Glucose Homeostasis

The Relationship of Fasting Free Fatty Acids, Adipose Tissue, Insulin Resistance, and Fasting Glucose Concentrations with Subsequent ß-Cell Function in Nondiabetic Subjects

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1812-P
Author(s):  
MARIA D. HURTADO ◽  
J.D. ADAMS ◽  
MARCELLO C. LAURENTI ◽  
CHIARA DALLA MAN ◽  
CLAUDIO COBELLI ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Free Fatty Acids ◽  
Cell Function ◽  
Fasting Glucose ◽  
Relationship Of ◽  
The Relationship

scholarly journals Article Commentary: A Role for IR-β in the Free Fatty Acid Mediated Development of Hepatic Insulin Resistance?

2009 ◽  
Vol 2 ◽  
pp. BCI.S2996
Author(s):  
Samit Shah ◽  
Arthur G. Cox
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Free Fatty Acids ◽  
Pi3k Pathway ◽  
Hepatic Insulin Resistance ◽  
Hamster Model ◽  
High Concentrations ◽  
Nfκb Pathway

Several studies have been conducted to elucidate the role of free fatty acids (FFAs) in the pathogenesis of type 2 diabetes, but the exact molecular mechanism by which FFAs alter glucose metabolism in the liver is still not completely understood. 1 – 4 In a recent publication, Ragheb and coworkers have examined the effect of free fatty acid (FFA) treatment on insulin signaling and insulin resistance by using immunoprecipitation and immunoblotting to study the effect of high concentrations of insulin and FFAs on insulin receptor-beta (IR-β) and downstream elements in the PI3K pathway using the fructose-fed hamster model. 5 Their results clearly show that free fatty acids have an insignificant effect on IR-β and supports previous findings that FFAs lead to insulin resistance in the liver via the PKC-NFκB pathway. 2 , 3

The Positive Correlation between Insulin Resistance and Duration of Hospitalization in Untreated Schizophrenia

1971 ◽  
Vol 118 (545) ◽  
pp. 429-436 ◽  
Author(s):  
Werner H. Schimmelbusch ◽  
Peter S. Mueller ◽  
Jack Sheps
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Chronic Schizophrenia ◽  
Intravenous Glucose ◽  
Plasma Free Fatty Acids ◽  
Chronic Schizophrenic ◽  
Duration Of Hospitalization ◽  
Schizophrenic Patients

Various abnormalities have been demonstrated in schizophrenic patients in response to injected insulin. Thomaset al.(22), Harris (8), Freemanet al.(7), Mayer-Gross (10), and Bracelandet al.(4) have shown a delayed or decreased response of blood glucose to insulin in schizophrenic patients. Meduna and McCulloch (11) observed that those schizophrenic patients who suffered from confusion and clouding of the sensorium particularly displayed a delayed or decreased response to injected insulin as well as a urinary hyperglycaemic factor and decreased tolerance to oral and intravenous glucose. Subsequent studies by Mueller (12, 13) demonstrated a rise or lack of fall in the plasma free fatty acids (FFA) following the administration of insulin intramuscularly or intravenously in chronic schizophrenic patients. Van Sickleet al.(23) confirmed these findings of insulin resistance in chronic schizophrenia and noted that this low FFA response was neither related to an abnormal release of, nor response to, epinephrine.

scholarly journals Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor- B Pathway in Rat Liver

Diabetes ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 3458-3465 ◽  
Author(s):  
G. Boden ◽  
P. She ◽  
M. Mozzoli ◽  
P. Cheung ◽  
K. Gumireddy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Nuclear Factor ◽  
Factor B
Sign in / Sign up

Export Citation Format

Share Document