The Relationship of Fasting Free Fatty Acids, Adipose Tissue, Insulin Resistance, and Fasting Glucose Concentrations with Subsequent ß-Cell Function in Nondiabetic Subjects

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1812-P
Author(s):  
MARIA D. HURTADO ◽  
J.D. ADAMS ◽  
MARCELLO C. LAURENTI ◽  
CHIARA DALLA MAN ◽  
CLAUDIO COBELLI ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Free Fatty Acids ◽  
Cell Function ◽  
Fasting Glucose ◽  
Relationship Of ◽  
The Relationship

The relationship of circulating glucose, ketones, and F.F.A. to milk production in Awassi ewes

1967 ◽  
Vol 69 (3) ◽  
pp. 349-354 ◽  
Author(s):  
J. H. Adler ◽  
E. Lotan
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Milk Production ◽  
Ketone Group ◽  
Relationship Of ◽  
The Relationship ◽  
Low Serum ◽  
Clinical Cases

The relationship between milk production, blood glucose, blood ketones and free fatty acids (F.F.A.) were studied in lactating Awassi ewes. Increased milk production in ewes was associated with diminished blood glucose and increased serum F.F.A. Clinical cases of ketosis were not observed.The ewes studied here could be divided into two metabolic populations depending on their blood ketone levels. Those with blood ketone levels of 11 mg % or more, did not show a significant increase in serum F.F.A. or a decrease in blood glucose values with increased milk production. The group of ewes with less than 11 mg % blood ketones showed a significant decrease in blood glucose and a significant increase in serum F.F.A. as milk production increased. Ketonemia of the high ketone group of ewes, was associated with relatively low serum F.F.A. levels. It is suggested that these ketones not originate from depot fat via serum F.F.A. These ketones and/or their precursors, acetic and butyric acids probably participate in caloric homeostasis and are associated with a glucose sparing serum F.F.A. suppressing mechanism.The suggestion that ketones derived from rumen (R.D.K.) should be distinguished from those derived from adipose tissue (A.D.K.) is discussed.

scholarly journals The Relationship of Insulin Resistance With SNP 276G>T at Adiponectin Gene and Plasma Long-Chain Polyunsaturated Fatty Acids in Obese Children

2009 ◽  
Vol 66 (3) ◽  
pp. 346-349 ◽  
Author(s):  
Elvira Verduci ◽  
Silvia Scaglioni ◽  
Carlo Agostoni ◽  
Giovanni Radaelli ◽  
Marialuisa Biondi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Adiponectin Gene ◽  
Obese Children ◽  
Relationship Of ◽  
The Relationship ◽  
Long Chain

scholarly journals Adipokines: mechanisms of metabolic and behavioral disorders

2018 ◽  
Vol 15 (3) ◽  
pp. 14-20
Author(s):  
Yassine Chahirou ◽  
Abdelhalim Mesfioui ◽  
Ali Ouichou ◽  
Aboubaker Hessni
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Behavioral Disorders ◽  
Health Problems ◽  
Endocrine Tissue ◽  
Physiological Functions ◽  
Relationship Of ◽  
The Relationship

Current studies show that metabolic and behavioral disorders represent severe health problems. Several questions arise about the molecular relationship of metabolic and behavioral disorders. This review will discuss the relationship of lipid metabolism and fructose consumption accompanied by an increase in weight as well as associated disorders: hypertension, insulin-resistance, oxidative stress and depression. Adipose tissue is considered as an endocrine tissue with intense secretory activities (metabolic and inflammatory). These adipokines are responsible for an alteration of several physiological functions. In this review we will try to understand how lipogenesis that causes dyslipidemia can influence insulin resistance, hypertension, oxidative stress, depression and the relationship between these various disorders.

scholarly journals Circulating Plasma Free Fatty Acids, Insulin Resistance and Metabolic Markers in Obese Women

2020 ◽  
Vol 13 (4) ◽  
pp. 1595-1600
Author(s):  
Moushira Zaki ◽  
Jihan Hussein ◽  
Amr M.M. Ibrahim ◽  
Eman R. Youness
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Anthropometric Measurements ◽  
Model Assessment ◽  
Obese Women ◽  
Metabolic Markers ◽  
The Metabolic Syndrome ◽  
The Relationship

Objectives:Elevation of free fatty acids (FFAs) in serum is an importantrisk factor for metabolic changes.Conversely, the relationship between obesity and metabolic abnormalities, and FFAsis not yet completely understood.Thus,we aimed in this study to explore the relationship and the association between insulin resistance (IR), metabolic markers and the variation inplasmaFFAs among the obese women. Methods:This study included fifty obese women aged 25–35 years and has insulin resistance (IR)in addition to fifty age-matched healthy normal weightwomen served as control group.Blood was withdrawn after twelve hours fasting;fasting blood glucose, lipidsand plasma insulinwere estimated;IR was assessedvia the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR).Fatty acids in plasma were measured by HPLC using UV detector that was set at 200 nm.Indeed, anthropometric measurements was performed . Results:Lipid profile, fasting blood sugar, insulin resistance, oleic acids (OA), linoleic acid (LA), arachidonic acid (AA) and anthropometric measurements were significantly increased in IR women compared to control. Whereas, the mean value levels of alpha-linolenicacid(ALA)was significantly decreased in IR women compare to controls. Conclusion:lower plasma levels of ALA and higher levels of AA, OA, LA were significantly associated with risk of IR and metabolic disorder markers in obese women.These results might explain the positive benefits of foods rich with poly unsaturated fatty acids (PUFA).Obesity and IR may be associated with the alterations in composition of the circulating fatty acid.These findings underscore the potential role of PUFA in the metabolic syndrome pathogenesis.

The relationship of blood pressure with glucose, insulin, heart rate, free fatty acids and plasma cortisol levels according to degree of obesity in middle-aged men

1996 ◽  
Vol 14 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Jan Filipovsky ◽  
Pierre Ducimetiere ◽  
Eveline Eschwege ◽  
Jacques L. Richard ◽  
Gabriel Rosselin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Heart Rate ◽  
Free Fatty Acids ◽  
Plasma Cortisol ◽  
Middle Aged ◽  
Cortisol Levels ◽  
Relationship Of ◽  
The Relationship

scholarly journals The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients

2020 ◽  
Vol 21 (15) ◽  
pp. 5220
Author(s):  
Dariusz Kotlega ◽  
Agnieszka Zembron-Lacny ◽  
Monika Golab-Janowska ◽  
Przemyslaw Nowacki ◽  
Malgorzata Szczuko
Keyword(s):  
Fatty Acids ◽  
Depressive Symptoms ◽  
Free Fatty Acids ◽  
Eicosatrienoic Acid ◽  
Stroke Patients ◽  
Lipoxin A4 ◽  
Tridecanoic Acid ◽  
Relationship Of ◽  
The Relationship

The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inventory-II (BDI-II) 7 days and 6 months after the stroke onset. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography. In the acute phase of stroke, BDI-II and FFAs inversely correlated with C13:0 tridecanoic acid, C15:1 cis-10-pentadecanoid acid, C17:1 cis-10- heptadecanoid acid, C18:0 stearic acid, C20:3n6 eicosatrienoic acid, C22:1cis13 docosenoic acid and C22:6n3 docosahexaenoic acid (DHA). DHA level was significantly lower in patients with low vs. high BDI-II score. In the follow-up examination, BDI-II score directly correlated with C16:0 palmitic acid. The changes in BDI-II score during 6-month observation inversely correlated with lipoxin A4 and protectin D1, and directly correlated with 5-oxo-ETE. Importantly, the severity of depressive symptoms was associated with n3 PUFA level. Diet-derived FFAs were observed to potentially affect the inflammatory pathways in pathogenesis of depression in stroke and reduced DHA levels can attenuate depressive symptoms in stroke patients.

Conjugated linoleic acid and trans C18:1 in muscle and adipose tissue of lambs fed supplements containing n-3 polyunsaturated fatty acids

2002 ◽  
Vol 2002 ◽  
pp. 182-182
Author(s):  
M. Enser ◽  
A.M. Wachira ◽  
L.A. Sinclair ◽  
R.G Wilkinson ◽  
K.G. Hallett ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Linoleic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Unsaturated Fatty Acids ◽  
Vaccenic Acid ◽  
Conjugated Linoleic Acids ◽  
Relationship Of ◽  
The Relationship

Conjugated linoleic acids (CLA) occur in the milk and tissues of ruminants. Although cis-9, trans-11 CLA is an intermediate in the biohydrogenation of linoleic acid in the rumen, duodenal flows of CLA are very low (Scollan et al, 2001) and most CLA appears to be synthesised in tissues from trans-11 C18:1 (vaccenic acid) (Griinari et al, 2000). Trans C18:1 isomers are also produced in the rumen and their amounts are increased when the levels of dietary unsaturated fatty acids are raised. We have investigated the relationship of tissue levels of CLA and trans C18:1 in three breeds of lambs fed supplements of linseed or fish oil to increase trans C18:1.

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