Differential characteristics of bone quality and bone turnover biochemical markers in patients with hip Fragility Fractures and Hip Osteoarthritis: results of a clinical pilot study

2011 ◽  
Vol 23 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Giuseppina Resmini ◽  
Silvia Migliaccio ◽  
Luca Dalle Carbonare ◽  
Umberto Sala ◽  
Marina Brama ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Turnover ◽  
Bone Quality ◽  
Biochemical Markers ◽  
Hip Osteoarthritis ◽  
Fragility Fractures

Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis: a single-blind, randomized pilot study

2001 ◽  
Vol 62 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Nicola Giordano ◽  
Emilio Battisti ◽  
Simone Geraci ◽  
Marco Fortunato ◽  
Clorinda Santacroce ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Pilot Study ◽  
Bone Turnover ◽  
Electromagnetic Fields ◽  
Bone Mineral ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Markers Of Bone Turnover ◽  
Single Blind

scholarly journals Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK

2010 ◽  
Vol 103 (12) ◽  
pp. 1706-1710 ◽  
Author(s):  
Nicola M. Lowe ◽  
Soma R. Mitra ◽  
Peter C. Foster ◽  
Issak Bhojani ◽  
John F. McCann
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
South Asian ◽  
Bone Quality ◽  
Biochemical Markers ◽  
Vitamin D Status ◽  
Amino Terminal ◽  
Markers Of Bone Turnover ◽  
Serum Pth

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50–66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen β C-telopeptide (βCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10·5 v. C 47·1 nmol/l; P < 0·001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7·3 v. C 4·5 pmol/l; P < 0·01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23·0 v. C 20·0 U/l; P < 0·05). No significant differences were observed between the two groups for P1NP, βCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

scholarly journals Use of Bone Turnover Markers in Clinical Osteoporosis Assessment in Women: Current Issues and Future Options

2011 ◽  
Vol 7 (6) ◽  
pp. 689-698 ◽  
Author(s):  
K Henriksen ◽  
DJ Leeming ◽  
C Christiansen ◽  
MA Karsdal
Keyword(s):  
High Risk ◽  
Bone Turnover ◽  
Bone Quality ◽  
Bone Turnover Markers ◽  
Biochemical Markers ◽  
Metabolic Diseases ◽  
Mineral Density ◽  
Dual Emission ◽  
Markers Of Bone Turnover ◽  
Turnover Markers

Monitoring bone turnover of the adult and aging skeleton is essential for optimal treatment of bone metabolic diseases, such as postmenopausal osteoporosis. Diagnosis of osteoporosis is based solely on dual-emission x-ray absorptiometry-based measurements of bone mineral density. However, within the last 20 years, biochemical markers of bone turnover have been implemented to a larger degree, and especially within the field of drug development. Numerous clinical studies have underscored that the markers have promise in terms of predicting patients at high risk of losing bone, future fracture events and importantly also the fracture efficacy of drugs in development. Furthermore, while classical methods often require years to monitor the changes, the bone turnover markers do so within a shorter time span. The aims of this article are to provide an update on the different biochemical markers of bone turnover, and to give an overview of their applications in epidemiological and clinical research especially in women. The main emphasis will be on their utility in clinical trials testing the efficacy of drugs for the treatment of osteoporosis, and their ability to supplement bone mass measurements. Finally, recent evidence suggests that biochemical markers may provide information on bone age that may indirectly relate to bone quality, and this is discussed together with future possibilities for measuring bone quality using bone turnover markers. In summary, a more targeted use of biomarkers could assist in the identification of high-risk patients, the process of drug discovery and monitoring of the efficacy of osteoporosis treatment in clinical settings.

Clinical and histomorphometrical assessment of bone quality in hip osteoarthritis and osteoporosis

2013 ◽  
Author(s):  
Maurizio Feola ◽  
Cecilia Rao ◽  
Monica Celi ◽  
Elena Gasbarra ◽  
Umberto Tarantino
Keyword(s):  
Bone Quality ◽  
Hip Osteoarthritis

scholarly journals Feasibility of exercise and weight management for people with hip osteoarthritis and overweight or obesity: a pilot study

2021 ◽  
pp. 100174
Author(s):  
Michelle Hall ◽  
Libby Spiers ◽  
Gabrielle Knox ◽  
Rana S. Hinman ◽  
Priya Sumithran ◽  
...  
Keyword(s):  
Pilot Study ◽  
Weight Management ◽  
Hip Osteoarthritis ◽  
Overweight Or Obesity
Sign in / Sign up

Export Citation Format

Share Document