scholarly journals The Impact of Routine Immunization Using Meningococcal C Conjugate Vaccine on Invasive Meningococcal Disease in British Columbia

2008 ◽  
Vol 99 (5) ◽  
pp. 380-382 ◽  
Author(s):  
Tung Siu ◽  
Wrency Tang ◽  
Meenakshi Dawar ◽  
David M. Patrick
Keyword(s):  
British Columbia ◽  
Conjugate Vaccine ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Routine Immunization ◽  
The Impact

scholarly journals Epidemiology of invasive meningococcal disease in Germany, 2002–2010, and impact of vaccination with meningococcal C conjugate vaccine

2013 ◽  
Vol 66 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Wiebke Hellenbrand ◽  
Johannes Elias ◽  
Ole Wichmann ◽  
Manuel Dehnert ◽  
Matthias Frosch ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease

scholarly journals Invasive Meningococcal Disease: What We Should Know, Before It Comes Back

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Carmen Cabellos ◽  
Ivan Pelegrín ◽  
Eva Benavent ◽  
Francesc Gudiol ◽  
Fe Tubau ◽  
...  
Keyword(s):  
Meningococcal Disease ◽  
Public Health Problem ◽  
Mortality Rates ◽  
Observational Cohort Study ◽  
Invasive Meningococcal Disease ◽  
Complication Rates ◽  
Neurological Sequelae ◽  
Long Period ◽  
Observational Cohort ◽  
The Impact

Abstract Background Invasive meningococcal disease (IMD), sepsis and/or meningitis continues to be a public health problem, with mortality rates ranging from 5% to 16%. The aim of our study was to further knowledge about IMD with a large series of cases occurring over a long period of time, in a cohort with a high percentage of adult patients. Methods Observational cohort study of patients with IMD between 1977 hand 2013 at our hospital, comparing patients with only sepsis and those with meningitis and several degrees of sepsis. The impact of dexamethasone and prophylactic phenytoin was determined, and an analysis of cutaneous and neurological sequelae was performed. Results A total of 527 episodes of IMD were recorded, comprising 57 cases of sepsis (11%) and 470 of meningitis with or without sepsis (89%). The number of episodes of IMD decreased from 352 of 527 (67%) in the first to 20 of 527 (4%) in the last quarter (P < .001). Thirty-three patients died (6%): 8 with sepsis (14%) and 25 with meningitis (5%) (P = .02). Cutaneous and neurological sequelae were present in 3% and 5% of survivors of sepsis and meningitis, respectively. The use of dexamethasone was safe and resulted in less arthritis, and patients given prophylactic phenytoin avoided seizures. Conclusions The frequency of IMD has decreased sharply since 1977. Patients with sepsis only have the highest mortality and complication rates, dexamethasone use is safe and can prevent some arthritis episodes, and prophylactic phenytoin might be useful in a selected population. A rapid response and antibiotic therapy may help improve the prognosis.

scholarly journals Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia

2007 ◽  
Vol 18 (6) ◽  
pp. 363-367 ◽  
Author(s):  
Grahame Quan ◽  
Mark Gilbert ◽  
Samara T David ◽  
Tazim Rahim ◽  
Kathy Adie ◽  
...  
Keyword(s):  
British Columbia ◽  
Meningococcal Disease ◽  
Gel Electrophoresis ◽  
Outer Membrane Proteins ◽  
Case Fatality ◽  
Pulsed Field Gel Electrophoresis ◽  
Invasive Meningococcal Disease ◽  
Sequencing Data ◽  
Outbreak Strain ◽  
Pulsed Field

Two major outbreaks of invasive meningococcal disease serogroup C (IMD-C) were identified in British Columbia between 2000 and 2004. Pulsed-field gel electrophoresis (PFGE) andporAgene sequencing of all retained IMD-C isolates were used to assess correlations between genotypes and epidemiological patterns. PFGE patterns of IMD-C genotypes correlated with epidemiological patterns between 2000 and 2004 in British Columbia, and demonstrated that PFGE can identify outbreak-related cases. Both IMD-C outbreaks correlated with a respective PFGE pattern. PFGE analysis demonstrated that the 2004 British Columbia outbreak strain in men who have sex with men was closely related to the 2001 Abbotsford outbreak strain.PorAsequencing data indicated low diversity of class 1 outer membrane proteins in British Columbia, and did not correlate with epidemiological trends. There was a trend for outbreak-associated PFGE types to demonstrate higher case fatality rates.

scholarly journals Impact and effectiveness of meningococcal vaccines: a review

2017 ◽  
Vol 41 ◽  
pp. 1
Author(s):  
Lucia Helena De Oliveira ◽  
Barbara Jauregui ◽  
Ana Flavia Carvalho ◽  
Norberto Giglio
Keyword(s):  
Conjugate Vaccine ◽  
Meningococcal Disease ◽  
Age Groups ◽  
Epidemiological Surveillance ◽  
Surveillance Systems ◽  
Protein Subunit ◽  
Conjugate Vaccines ◽  
Vaccination Programs ◽  
Meta Analyses ◽  
The Impact

Objectives.To summarize and critically evaluate the evidence on the impact and effectiveness of meningococcal vaccination programs around the world in order to inform decisionmaking in Latin America and the Caribbean.Methods.A review of the literature was conducted following several components of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed Central® was searched for papers published in any language from January 1999 – March 2017.Results.In all, 32 studies were included, most of which evaluated the meningococcal C conjugate vaccine. Fourteen studies measured effectiveness and 30 measured impact. The effectiveness of polysaccharide vaccines was 65% – 83.7% (different age groups), while the effectiveness of the conjugate vaccines was 66% – 100%. Incidence decline of laboratory-confirmed meningococcal disease for the conjugate vaccine ranged from 77% – 100% among different ages groups. The only study that evaluated the protein subunit vaccine reported a vaccine effectiveness of 82.9%.Conclusions.The studies reviewed show impact and effectiveness of both polysaccharide vaccines and conjugate vaccines on vaccine-serogroup meningococcal disease. The conjugate vaccines, however, show higher impact and effectiveness with longer-lasting protection over the polysaccharide vaccines. Given the variance in potential use of a meningococcal vaccine, epidemiological surveillance systems should be strengthened to inform national decisions.

Invasive Meningococcal Disease in Africa’s Meningitis Belt: More Than Just Meningitis?

2019 ◽  
Vol 220 (Supplement_4) ◽  
pp. S263-S265 ◽  
Author(s):  
Heather E Reese ◽  
Olivier Ronveaux ◽  
Jason M Mwenda ◽  
Andre Bita ◽  
Adam L Cohen ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Meningococcal Disease ◽  
Disease Surveillance ◽  
Clinical Presentation ◽  
Case Fatality ◽  
Clinical Syndrome ◽  
Invasive Meningococcal Disease ◽  
World Health ◽  
Case Fatality Ratio ◽  
Meningitis Belt

Abstract Since the progressive introduction of the meningococcal serogroup A conjugate vaccine within Africa’s meningitis belt beginning in 2010, the burden of meningitis due to Neisseria meningitidis serogroup A (NmA) has substantially decreased. Non-A serogroups C/W/X are now the most prevalent. Surveillance within the belt has historically focused on the clinical syndrome of meningitis, the classic presentation for NmA, and may not adequately capture other presentations of invasive meningococcal disease (IMD). The clinical presentation of infection due to serogroups C/W/X includes nonmeningeal IMD, and there is a higher case-fatality ratio associated with these non-A serogroups; however, data on the nonmeningeal IMD burden within the belt are scarce. Expanding surveillance to capture all cases of IMD, in accordance with the World Health Organization’s updated vaccine-preventable disease surveillance standards and in preparation for the anticipated introduction of a multivalent meningococcal conjugate vaccine within Africa’s meningitis belt, will enhance meningococcal disease prevention across the belt.

The Impact of Meningococcal Polymerase Chain Reaction Testing on Laboratory Confirmation of Invasive Meningococcal Disease

2012 ◽  
Vol 31 (3) ◽  
pp. 316-318 ◽  
Author(s):  
Richard J. Drew ◽  
Cilian Ó Maoldomhnaigh ◽  
Patrick J. Gavin ◽  
Nicola Oʼ Sullivan ◽  
Karina M. Butler ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Chain Reaction ◽  
Polymerase Chain Reaction Testing ◽  
Laboratory Confirmation ◽  
Polymerase Chain ◽  
The Impact

scholarly journals Meningococcal C conjugate vaccine effectiveness before and during an outbreak of invasive meningococcal disease due to Neisseria meningitidis serogroup C/cc11, Tuscany, Italy

Vaccine ◽  
2018 ◽  
Vol 36 (29) ◽  
pp. 4222-4227 ◽  
Author(s):  
Patrizio Pezzotti ◽  
Alessandro Miglietta ◽  
Arianna Neri ◽  
Cecilia Fazio ◽  
Paola Vacca ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Conjugate Vaccine ◽  
Meningococcal Disease ◽  
Vaccine Effectiveness ◽  
Invasive Meningococcal Disease
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