Combined effect of pioglitazone and simvastatin on urinary liver-type fatty acid-binding protein concentration in diabetic patients with microalbuminuria

Diabetologia ◽  
2007 ◽  
Author(s):  
J. Wei ◽  
C. Ma ◽  
Y. M. Li
Keyword(s):  
Fatty Acid ◽  
Protein Concentration ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Combined Effect ◽  
Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Associations between Fatty Acid-Binding Protein 4–A Proinflammatory Adipokine and Insulin Resistance, Gestational and Type 2 Diabetes Mellitus

Cells ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 227 ◽  
Author(s):  
Marcin Trojnar ◽  
Jolanta Patro-Małysza ◽  
Żaneta Kimber-Trojnar ◽  
Bożena Leszczyńska-Gorzelak ◽  
Jerzy Mosiewicz
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Clinical Aspects ◽  
Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

There is ample scientific evidence to suggest a link between the fatty acid-binding protein 4 (FABP4) and insulin resistance, gestational (GDM), and type 2 (T2DM) diabetes mellitus. This novel proinflammatory adipokine is engaged in the regulation of lipid metabolism at the cellular level. The molecule takes part in lipid oxidation, the regulation of transcription as well as the synthesis of membranes. An involvement of FABP4 in the pathogenesis of obesity and insulin resistance seems to be mediated via FABP4-dependent peroxisome proliferator-activated receptor γ (PPARγ) inhibition. A considerable number of studies have shown that plasma concentrations of FABP4 is increased in obesity and T2DM, and that circulating FABP4 levels are correlated with certain clinical parameters, such as body mass index, insulin resistance, and dyslipidemia. Since plasma-circulating FABP4 has the potential to modulate the function of several types of cells, it appears to be of extreme interest to try to develop potential therapeutic strategies targeting the pathogenesis of metabolic diseases in this respect. In this manuscript, representing a detailed review of the literature on FABP4 and the abovementioned metabolic disorders, various mechanisms of the interaction of FABP4 with insulin signaling pathways are thoroughly discussed. Clinical aspects of insulin resistance in diabetic patients, including women diagnosed with GDM, are analyzed as well.

scholarly journals Distinct Roles of Urinary Liver-Type Fatty Acid-Binding Protein in Non-Diabetic Patients with Anemia

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126990 ◽  
Author(s):  
Naohiko Imai ◽  
Takashi Yasuda ◽  
Atsuko Kamijo-Ikemori ◽  
Yugo Shibagaki ◽  
Kenjiro Kimura
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Increased Fatty Acid-Binding Protein Concentration in Plasma of Patients with Chronic Renal Failure

1997 ◽  
Vol 43 (1) ◽  
pp. 193-195 ◽  
Author(s):  
Jan Górski ◽  
Wim T Hermens ◽  
Jacek Borawski ◽  
Michal Mysliwiec ◽  
Jan F C Glatz
Keyword(s):  
Renal Failure ◽  
Fatty Acid ◽  
Chronic Renal Failure ◽  
Protein Concentration ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients

2007 ◽  
Vol 195 (1) ◽  
pp. e150-e158 ◽  
Author(s):  
A. Cabré ◽  
I. Lázaro ◽  
J. Girona ◽  
J.M. Manzanares ◽  
F. Marimón ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Serum Heart-Type Fatty Acid-Binding Protein Concentration Positively Correlates With the Length of Aortic Dissection

2005 ◽  
Vol 69 (8) ◽  
pp. 958-961 ◽  
Author(s):  
Hiroshi Hazui ◽  
Nobuyuki Negoro ◽  
Masayoshi Nishimoto ◽  
Hideyuki Muraoka ◽  
Motonobu Murai ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Aortic Dissection ◽  
Protein Concentration ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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