Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study

2013 ◽  
Vol 48 (9) ◽  
pp. 1357-1365 ◽  
Author(s):  
Arjen L. Sutterland ◽  
Jeanne Dieleman ◽  
Jitschak G. Storosum ◽  
Bettie A. C. Voordouw ◽  
Jojanneke Kroon ◽  
...  
2018 ◽  
Vol 45 (2) ◽  
pp. 360-368 ◽  
Author(s):  
Qiong Wu ◽  
Christina Dalman ◽  
Håkan Karlsson ◽  
Glyn Lewis ◽  
David P J Osborn ◽  
...  

2018 ◽  
Author(s):  
David Dodell-Feder ◽  
Abhishek Saxena ◽  
Lauren Rutter ◽  
Laura Germine

Outcomes for people with schizophrenia-spectrum disorders (SSDs) are generally poor making it important to understand risk states and illness transition. The network approach, which conceptualizes psychopathology as a network of causally interacting symptoms, may hold promise in this regard. Here, we present a network analysis of schizotypy—the personality organization involving schizophrenia-like phenomena that is thought to index one’s vulnerability for an SSD—using an international, population-based sample. In line with other research, we find that the schizotypy network is densely connected, characterized by three communities of items with interpersonal and disorganized features exhibiting the greatest centrality and predictability. Further, we find network differences between certain groups differing in levels of SSD risk. Together, these findings demonstrate the utility of using network approaches to understand SSD risk states as well as the replicability of network findings on schizotypy and related SSD risk concepts.


2018 ◽  
Vol 127 (10) ◽  
pp. 694-697 ◽  
Author(s):  
Malcolm Koo ◽  
Jen-Tsung Lai ◽  
Edward Yih-Liang Yang ◽  
Tien-Chen Liu ◽  
Juen-Haur Hwang

Objectives: Vestibular schwannomas, also known as acoustic neuromas, are slow-growing tumors that may lead to asymmetric hearing loss, unilateral tinnitus, and vertigo. Population-based data are lacking regarding the incidence of vestibular schwannoma in Asian populations. The aim of this study was to investigate the incidence of vestibular schwannoma in Taiwan using data from a population-based health claim database. Subjects and Methods: Patients aged 20 years and over with incident cases of vestibular schwannoma between January 1, 2001, and December 31, 2012, were identified from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database (NHIRD), Taiwan, based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) code 225.1. Only those patients who had received a magnetic resonance imaging scan prior to the diagnosis of vestibular schwannoma were considered as definitive cases. Results: 206 cases of vestibular schwannoma were identified during the interval 2001 to 2012. The overall annual incidence was 2.66 per 100 000 persons (95% confidence interval, 2.32-3.05). The annual incidence rate varied throughout the study period, ranging from 1.74 to 3.72 per 100 000 persons. The highest incidence rate of 4.86 per 100 000 persons was observed in the age group of 60 to 69 years. Conclusions: Based on data from the NHIRD in Taiwan for the years 2001 to 2012, the average annual incidence rate of vestibular schwannoma was found to be 2.66 per 100 000 persons.


2020 ◽  
Vol 91 (5) ◽  
pp. 593-597 ◽  
Author(s):  
Andreas V Larsen ◽  
Esben Mundbjerg ◽  
Jens M Lauritsen ◽  
Christian Faergemann

2020 ◽  
Author(s):  
Ramon Scharbaai ◽  
Raymond L Tremblay

Abstract Background: Sarcoidosis is a systemic granulomatous and inflammatory disorder with significantvariability in ethnicity and geographical distribution. There is no descriptive data about theepidemiology of the disease among the geographically isolated Puerto Rican population.Objective: To estimate the incidence, prevalence, distribution, and healthcare burden ofsarcoidosis in a large nationwide population-based cohort in Puerto Rico.Methods: We conducted a descriptive and retrospective analysis using the health administrativeclaim database from the Puerto Rico Health Insurance Administration (ASES) from 2016 to 2018.The International Classification of Diseases-Tenth Revision coding (D86) was used for casedetection. Data on sex and age were used to estimate incidence and prevalence.Results: A total of 539 sarcoidosis cases were identified over the 3-year study. The median ageat diagnosis was 59 years old. The average annual incidence rate was 9.4/100,000. The baselineprevalence was 15.4 per 100,000. Females represented the 67.5% of the cases. The frequency ofsarcoidosis in women was higher than in males starting at the age range 18-34 years (GLMp<0.03). Patients with lung and unspecified sarcoidosis predominates with 37% and 32% of cases,respectively.Conclusions: Annual incidence rate of sarcoidosis in Island Puerto Ricans is among the highestin a single geographically isolated ethnic group reported globally. The overall mean age ofindividuals with sarcoidosis in Puerto Rico represent the oldest among previous epidemiologicalsurveys conducted worldwide.


2016 ◽  
Vol 175 (3) ◽  
pp. 181-190 ◽  
Author(s):  
Jakob Dal ◽  
Ulla Feldt-Rasmussen ◽  
Marianne Andersen ◽  
Lars Ø Kristensen ◽  
Peter Laurberg ◽  
...  

Design Valid data on acromegaly incidence, complications and mortality are scarce. The Danish Health Care System enables nationwide studies with complete follow-up and linkage among health-related databases to assess acromegaly incidence, prevalence, complications and mortality in a population-based cohort study. Method All incident cases of acromegaly in Denmark (1991–2010) were identified from health registries and validated by chart review. We estimated the annual incidence rate of acromegaly per 106 person-years (py) with 95% confidence intervals (95% CIs). For every patient, 10 persons were sampled from the general population as a comparison cohort. Cox regression and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were used. Results Mean age at diagnosis (48.7 years (CI: 95%: 47.2–50.1)) and annual incidence rate (3.8 cases/106 persons (95% CI: 3.6–4.1)) among the 405 cases remained stable. The prevalence in 2010 was 85 cases/106 persons. The patients were at increased risk of diabetes mellitus (HR: 4.0 (95% CI: 2.7–5.8)), heart failure (HR: 2.5 (95% CI: 1.4–4.5)), venous thromboembolism (HR: 2.3 (95% CI: 1.1–5.0)), sleep apnoea (HR: 11.7 (95% CI: 7.0–19.4)) and arthropathy (HR: 2.1 (95% CI: 1.6–2.6)). The complication risk was also increased before the diagnosis of acromegaly. Overall mortality risk was elevated (HR: 1.3 (95% CI: 1.0–1.7)) but uninfluenced by treatment modality. Conclusion (i) The incidence rate and age at diagnosis of acromegaly have been stable over decades, and the prevalence is higher than previously reported. (ii) The risk of complications is very high even before the diagnosis. (iii) Mortality risk remains elevated but uninfluenced by mode of treatment.


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