The Effect of Multi-generational Exposure to Metals and Resultant Change in Median Lethal Toxicity Tests Values Over Subsequent Generations

2007 ◽  
Vol 80 (1) ◽  
pp. 63-67 ◽  
Author(s):  
V. J. Vedamanikam ◽  
N. A. M. Shazilli
Keyword(s):  
Toxicity Tests ◽  
Lethal Toxicity

scholarly journals Uji Toksisitas Letal dan Subletal Logam Berat Merkuri (Hg) Terhadap Ikan Nilem (Osteochilus hasselti)

Omni-Akuatika ◽  
2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Norman Arie Prayogo ◽  
Atik Hidayati ◽  
Asrul Sahri Siregar
Keyword(s):  
Heavy Metal ◽  
Toxicity Test ◽  
Aquatic Organisms ◽  
Sublethal Effect ◽  
Aquatic Organism ◽  
Toxicity Tests ◽  
Sublethal Toxicity ◽  
Lethal Toxicity ◽  
Randomized Design ◽  
Completely Randomized Design

Mercury (Hg) is a heavy metal could pollute the river. Hg impacts on aquatic organism chronically. The influence of chemical toxic on aquatic organisms could be determined using toxicity (lethal and sublethal) tests. Osteochilus hasselti could be an object for toxicity test. A research, aiming to find LC50-96h concentration, was to find letal and subletal effects of Hg on erythrocyte and hematocryte changes. An experimental method applied Completely Randomized Design. The research was devided into 3 stages, i.e. preliminary, lethal toxicity (LC50-96h) and sublethal toxicity tests, in triplicates. Sampling of sublethal test was performed after an exposure time of 96 h (4 days) and 288 h (12 days). Lethal toxicity test data were analyzed as probit and data from sublethal toxicity test were F-tested. The result showed that LC50-96h of Hg on Osteochilus hasselti was 0.39 mg/L. The sublethal effect of Hg decreased erythrocyte ad hematocryte counts in parallel with increasing its concentration and its exposure time.Keywords: Hg, toxicity, LC50-96 hours, erythrocytes, hematocrits.

Is Atyaephyra desmarestii a useful candidate for lethal and sub-lethal toxicity tests on pharmaceutical compounds?

2013 ◽  
Vol 263 ◽  
pp. 256-265 ◽  
Author(s):  
Elena Nieto ◽  
Julián Blasco ◽  
Enrique González-Ortegón ◽  
Pilar Drake ◽  
Miriam Hampel
Keyword(s):  
Pharmaceutical Compounds ◽  
Toxicity Tests ◽  
Lethal Toxicity

Study of the radiomodifier effect of Pityrocarpa moniliformis extract

2019 ◽  
Vol 7 (2A) ◽  
Author(s):  
João Victor Torres de Moraes ◽  
Ricardo Luiz Calazans Luna Filho ◽  
Williams Nascimento de Siqueira ◽  
Hianna Arely Milca Fagundes Silva ◽  
Dewson Rocha Pereira ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cellular Response ◽  
Biomphalaria Glabrata ◽  
Toxicity Tests ◽  
Antioxidant Compounds ◽  
Blastula Stage ◽  
Natural Substances ◽  
60Co Source ◽  
60Co Gamma ◽  
60Co Gamma Radiation

Ionizing radiation has been applied in several areas of knowledge, among them the study of the radiomodifier activity of natural substances. These substances can modify the cellular response to the damage induced by the radiation. Therefore, this work aimed to evaluate the radiomodifier action of Pityrocarpa moniliformis extract on Biomphalaria glabrata embryos exposed to 60Co gamma radiation. Initially, toxicity tests were performed on the extract against the B. glabrata embryos for the choice of concentration that did not cause death and embryonic malformation. Then, the antioxidant activity of the P. moniliformis extract with flavonoids and phenolic compounds was evaluated by means of the ABTS method. To evaluate the radiomodifier activity of the extract, embryos were selected in the blastula stage and irradiated with 7.5 Gy in a 60Co source (gammacell-Co60). Then, the embryos were exposed for 24 h to the extract of P. moniliformis at a concentration of 250 μg/mL. The results showed that the extract of P. moniliformis presents flavonoids and enzymatic inhibition by ABTS, which demonstrates the presence of antioxidant compounds. However, the tests of the radiomodifier activity did not present radioprotective effect for embryos exposed to ionizing radiation.

Sign in / Sign up

Export Citation Format

Share Document