scholarly journals Fatal hemorrhage after tonsillectomy

Rechtsmedizin ◽  
2021 ◽  
Author(s):  
Katharina Feld ◽  
W. Mellin ◽  
B. Melzer ◽  
Markus A. Rothschild ◽  
Jochen Fries
Keyword(s):  
Family History ◽  
Vascular Disease ◽  
Radiographic Diagnosis ◽  
First Report ◽  
Aneurysm Formation ◽  
Fatal Hemorrhage ◽  
History Of ◽  
Reparative Changes

AbstractThis is the first report of a segmental mediolysis occurring in arterioles, affecting the neck/tonsillar region and leading to a fatal hemorrhage after a tonsillectomy in a 20-year-old woman. Arteriolar mediolysis could be observed in tissue layers about 2 cm distant from the tonsillectomy region. Reparative changes were observed in the carotid and small neck arteries as well as in only one intramyocardial arteriole; however, no other vascular regions typically reported in segmental mediolysis arteriopathy were affected and aneurysm formation was not observed. No family history of vascular disease or hypertension was known. Pathophysiologically, previously reported reasons for post-tonsillectomy bleeding could be excluded. Segmental mediolysis may represent a wider spectrum of affected arteriolar vessels besides the reported small and medium sized arteries leading to aneurysms, which impedes radiographic diagnosis.

scholarly journals Early Carotid Atherosclerosis and Family History of Vascular Disease

2003 ◽  
Vol 23 (2) ◽  
pp. 302-306 ◽  
Author(s):  
Paula Jerrard-Dunne ◽  
Hugh S. Markus ◽  
Donata A. Steckel ◽  
Alexandra Buehler ◽  
Stefan von Kegler ◽  
...  
Keyword(s):  
Family History ◽  
Vascular Disease ◽  
Carotid Atherosclerosis ◽  
History Of

Malignant Triton Tumor Presenting as a Rectal Mass in an 11-Month-Old

2005 ◽  
Vol 8 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Dale A. Ellison ◽  
Julissa Corredor-Buchmann ◽  
David M. Parham ◽  
Richard J. Jackson
Keyword(s):  
Family History ◽  
White Male ◽  
Malignant Triton Tumor ◽  
First Report ◽  
Café Au Lait Spots ◽  
Rectal Mass ◽  
History Of

We report the case of an 11-month-old white male who had a family history of neurofibromatosis, had multiple café-au-lait spots on the trunk and extremities, and was diagnosed with a malignant triton tumor of the rectum. To our knowledge, this is the first report of a malignant triton tumor of the rectum and one of the youngest patients reported with the tumor.

scholarly journals Cholesterol screening and family history of vascular disease.

1994 ◽  
Vol 71 (3) ◽  
pp. 239-242 ◽  
Author(s):  
E D Primrose ◽  
J M Savage ◽  
C A Boreham ◽  
G W Cran ◽  
J J Strain
Keyword(s):  
Family History ◽  
Vascular Disease ◽  
Cholesterol Screening ◽  
History Of

Abstract 109: Manipulative Dexterity is Associated with Occult White Matter Ischemic Lesions in Healthy Asymptomatic Persons at Increased Risk for Cardiovascular Disease

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Paul A Nyquist ◽  
Lisa R Yanek ◽  
Murat Bilgel ◽  
Jennifer L Cuzzocreo ◽  
Lewis C Becker ◽  
...  
Keyword(s):  
White Matter ◽  
Family History ◽  
Cerebrovascular Disease ◽  
Vascular Disease ◽  
Large Population ◽  
Manual Dexterity ◽  
Excess Risk ◽  
Small Vessel ◽  
Visual Spatial ◽  
History Of

Introduction: Persons with a family history of early-onset coronary artery disease (CAD) have an excess risk of stroke and CAD. White matter lesions (WML) on MRI represent small vessel ischemic cerebrovascular disease and are associated with incident stroke and neurocognitive decline with age. We hypothesized manipulative manual dexterity, an integration of fine motor, visual spatial, and cognition function, may be affected by increased WML burden in task-relevant brain regions across age ranges in persons at risk for pre-clinical occult vascular disease. We tested this in a large population with a family history of early CAD. Methods: Healthy 29-74 year old subjects (N=714; mean age 51± 11 years; mean education 14 ± 3 years; 42% male, 38% Black) were identified from probands with CAD <60 years. WML location and volumes were measured on 3T FLAIR MRI. Manipulative manual dexterity was measured with standardized timed grooved pegboard test. Left and right pegboard scores were averaged. Results: WML were observed in all age groups; mean overall pegboard scores were 108±18, and were within reference norms. In unadjusted analysis, pegboard scores were highly correlated in the expected direction with total WML volumes, r=0.34, p=<.0001; subcortical volumes r=0.30, <.0001 periventricular volumes r=0.31, <.0001; and with most regional WML volumes; frontal 0.34, <.0001; insula r=0.31, p<.0001, parietal r=0.31, p<.0001, and temporal volumes r=0.17, p <.0001. In separate multivariate regression analyses predicting (log) pegboard score adjusted for age, sex, race, education and nonindependence of families (GEE), total WML volume became more statistically significant ( p=5.79E-05) while other regions retained statistical significance, p< 0.01. Conclusions: Our findings in a large population-based sample with a family history of early CAD confirm that greater WML volumes in multiple brain locations are associated with higher pegboard scores (worse performance) independent of age, sex, race, and education. This suggests that small vessel cerebrovascular disease is present in an early preclinical state and that WML volumes impact manipulative manual dexterity in healthy middle-aged and younger individuals with excess risk for clinical vascular disease.

Dyslipoproteinemia and Migraine

PEDIATRICS ◽  
1986 ◽  
Vol 78 (5) ◽  
pp. 956-957
Author(s):  
CHARLES J. GLUECK
Keyword(s):  
Myocardial Infarction ◽  
Essential Hypertension ◽  
Family History ◽  
High Risk ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Cerebrovascular Accident ◽  
Peripheral Vascular ◽  
Parental History ◽  
History Of

In Reply.— Because the anatomic, biochemical, epidemiologic, nutritional, genetic, and clinical genesis of atherosclerosis is in childhood,1,2 it is important to consider models for sampling in childhood for the dyslipoproteinemias. At a minimum, I would recommend a family history-triggered high-risk strategy with sampling of all children whose parents had sustained premature (≤age 60 years) myocardial infarction, angina, cerebrovascular accident, or peripheral vascular disease.1,2 Second, all children with known parental dyslipoproteinemia should be sampled, as should all children with parental history of essential hypertension gout/hyperuricemia, and/or diabetes.

Abstract 100: Prevalence of Peripheral Vascular Disease Among Patients Using Cannabis, an Analysis of the 2014 National Inpatient Sample data

2017 ◽  
Vol 10 (suppl_3) ◽  
Author(s):  
Adeyinka C Adejumo ◽  
Samson Alliu ◽  
Tokunbo O Ajayi ◽  
Adegbala M Oluwole ◽  
Nnaemeka Onyeakusi ◽  
...  
Keyword(s):  
Family History ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Protective Factor ◽  
The United States ◽  
Bivariate Analysis ◽  
National Inpatient Sample ◽  
Peripheral Vascular ◽  
History Of ◽  
Anti Inflammatory

Background: Despite being illegal in most countries, cannabis is highly utilised by a growing number of individuals for recreational purposes worldwide. With its increasing legalisation in many states across the United States, the effects of cannabis on different body systems are expected to rise. Its association with peripheral vascular disease (PVD) remains ambiguous. Objective: To examine if there is a difference in prevalence of PVD amongst patients who use cannabis when compared to non-users. Methods: Using the 2014 National Inpatient Sample database (N=7,071,762), we identified patients with and without a diagnosis of PVD. We also identified patients using cannabis (nondependent and dependent users) and non-users. We performed the univariate and bivariate analysis. After we had composed the crude models, we adjusted for every known risk factor for PVD. These factors included age, gender, tobacco, hypercholesterolemia, coronary artery disease (CAD), cerebrovascular vessel disease (CVD), hypertension, diabetes, renal failure, alcohol, obesity, race, insurance type, average income at the location of residence, and family history of PVD/CVD/CAD. Results: In our total 7,071,762 sample, 98.27% (6,949,339) are non-users, 1.54% (108,910) are nondependent users and 0.19% (13,513) are dependent users. About 3.75% (264,920) of the patients had a diagnosis of PVD versus 96.25% (6,806,842) without a diagnosis of PVD. The odds of PVD is 20% less among nondependent users when compared to nonusers (AOR 0.80[0.76-0.85]). Furthermore, dependent users have a 55% reduced odds of developing PVD when compared to nonusers (AOR 0.45[0.35-0.57]) showing a dose-response relationship. The in-group comparison showed that dependent users were 44% less likely to have PVD when compared to non-dependent users (AOR: 0.56[0.44-0.72]). Overall, the odds of PVD remain significantly high among patients who uses tobacco (AOR 1.97 [1.95-1.99]), diabetes (AOR 1.54 [1.53-1.55]), hypercholesterolemia (AOR 1.46 [1.45-1.47]), family history of PVD/CVD/CAD (AOR 1.03 [1.01-1.05]), personal history of CAD (AOR 2.55 [2.53-2.57]). Conclusions: Cannabis is an independent protective factor against PVD. Molecular biology evidence shows that cannabis contains various bioactive agents. Beta-caryophyllene (out of many) preferentially binds to CB-2 receptors on immune cells causing an anti-inflammatory response. We believe that more molecular studies targeting such receptors or isolating such anti-inflammatory compounds in cannabis might be useful in the treatment of vascular disease.

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