Ethnic South Asian ischaemic stroke patients have a higher prevalence of a family history of vascular disease compared to age, gender and diabetes-matched ethnic Chinese subjects

Abstract Objectives The aim of this study was to assess the dietary intakes of lutein, zeaxanthin (L + Z) and omega-3-essential fatty acid(EFA) among a selected population of Australian based adults and to examine the effect of specified risk factors for age-related macular degeneration(AMD) on those levels. Methods A cross-sectional study involving 70 adults aged 19–52 years was carried out. Demographic data were obtained using an online self-administered questionnaire while dietary intakes were estimated using USDA's 24 hours recall questionnaire, the Victorian Cancer Council(Australia) food frequency questionnaire and anthropometric characteristics were obtained using a body composition analyzer. Dietary intakes of lutein, zeaxanthin, omega-3-EFA and anthropometric indices against the risk of AMD were established using descriptive statistics and Spearman correlation. Results The mean age of the population was 29.9 ± 8.1years with 51% men and 49% women. Women had a higher intake of L + Z (1908.6 μg/day versus 1032.8 μg/day) and alpha-linolenic acid(ALA) compared to men(1.7 ± 1.1 g/day versus 1.6 ± 1.2 g/day). Men consumed more omega-3-EFA than women (433 ± 397.1 mg/day versus 365 ± 210.7 mg/day). L + Z levels were higher among people of Middle Eastern and South Asian origin (>4000 μg/day) in the 19–25years age group. People of Middle Eastern, South East Asian and South Asian had the highest intake of omega-3-EFA(>500 mg/day) at ages 19–25, 26–32 and 34–52years respectively. Women aged 34–52years with a family history of AMD had higher levels of L + Z(>2500 μg/day) while women aged 26–32years with a family history of AMD had higher levels of ALA(>3 g/day). Ethnicity and L + Z were correlated (P = −0.456, P < 0.02). Higher levels of intake of L + Z (>4000 μg/day) were seen in participants aged 34–52years with a 5–10years residence in Australia. Participants who had less than 5–10years of residency had higher levels of omega-3-EFA(>500 mg/day) for ages 26–32years while those aged 34–52years who had less than 5years of residency had higher ALA(>4 g/day). Conclusions Intake levels for L + Z vary significantly among participants. Culturally specific dietary habits could feasibly influence the levels of intake of L + Z. Intake levels of omega-3-EFA were met. This study provides detailed intake levels of L + Z and omega-3-EFA for the ‘at-risk’ AMD group. Funding Sources No funding source.

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Development of a questionnaire to identify persons with a family history of aneurysmal subarachnoid hemorrhage

International Journal of Stroke ◽

10.1177/17474930211069004 ◽

2022 ◽

pp. 174749302110690

Author(s):

Charlotte CM Zuurbier ◽

Jacoba P Greving ◽

Gabriel JE Rinkel ◽

Ynte M Ruigrok

Keyword(s):

Subarachnoid Hemorrhage ◽

Family History ◽

Aneurysmal Subarachnoid Hemorrhage ◽

Positive Family History ◽

Stroke Patients ◽

Degree Relative ◽

First Degree Relatives ◽

Family History Questionnaire ◽

Affected Relative ◽

History Of

Background: Preventive screening for intracranial aneurysms is effective in persons with a positive family history of aneurysmal subarachnoid hemorrhage (aSAH), but for many relatives of aSAH patients, it can be difficult to assess whether their relative had an aSAH or another type of stroke. Aim: We aimed to develop a family history questionnaire for people in the population who believe they have a first-degree relative who had a stroke and to assess its accuracy to identify relatives of aSAH patients. Methods: A questionnaire to distinguish between aSAH and other stroke types (ischemic stroke and intracerebral hemorrhage) was developed by a team of clinicians and consumers. The level of agreement between the questionnaire outcome and medical diagnosis was pilot tested in 30 previously admitted aSAH patients. Next, the sensitivity and specificity of the questionnaire were assessed in 91 first-degree relatives (siblings/children) of previously admitted stroke patients. Results: All 30 aSAH patients were identified by the questionnaire in the pilot study; 29 of 30 first-degree relatives of aSAH patients were correctly identified. The questionnaire had a sensitivity of 97% (95% confidence interval (CI) = 83–100%) and a specificity of 93% (95% CI = 84–98%) when tested in the first-degree relatives of stroke patients. Conclusion: Our questionnaire can help persons to discriminate an aSAH from other types of stroke in their affected relative. This family history questionnaire is developed in the Netherlands but could also be used in other countries after validation.

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Early Carotid Atherosclerosis and Family History of Vascular Disease

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.0000051383.75507.60 ◽

2003 ◽

Vol 23 (2) ◽

pp. 302-306 ◽

Cited By ~ 34

Author(s):

Paula Jerrard-Dunne ◽

Hugh S. Markus ◽

Donata A. Steckel ◽

Alexandra Buehler ◽

Stefan von Kegler ◽

...

Keyword(s):

Family History ◽

Vascular Disease ◽

Carotid Atherosclerosis ◽

History Of

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Family History of Atherosclerotic Vascular Disease Is Associated With the Presence of Abdominal Aortic Aneurysm

Journal of Vascular Surgery ◽

10.1016/j.jvs.2016.05.059 ◽

2016 ◽

Vol 64 (1) ◽

pp. 260

Author(s):

Z. Ye ◽

K.R. Bailey ◽

E. Austin

Keyword(s):

Abdominal Aortic Aneurysm ◽

Family History ◽

Aortic Aneurysm ◽

Vascular Disease ◽

Atherosclerotic Vascular Disease ◽

Abdominal Aortic ◽

History Of

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Urinary dopamine and noradrenaline outputs during oral salt loading in healthy Chinese subjects with a family history of hypertension

Journal of Autonomic Pharmacology ◽

10.1111/j.1474-8673.1996.tb00349.x ◽

1996 ◽

Vol 16 (1) ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

T. Y. K. Chan ◽

J. A. J. H. Critchley ◽

C S. Ho ◽

J. C N. Chan ◽

B. Tomlinson

Keyword(s):

Family History ◽

Salt Loading ◽

History Of ◽

Urinary Dopamine ◽

Family History Of Hypertension ◽

Healthy Chinese ◽

Chinese Subjects

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Micro-albuminuria in non-diabetic acute ischaemic stroke: prevalence and its co-relation with stroke severity

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20170647 ◽

2017 ◽

Vol 5 (3) ◽

pp. 982 ◽

Cited By ~ 1

Author(s):

Sumeet Singh ◽

Harpreet Singh ◽

Tarsem Pal Singh

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Urinary Albumin ◽

P Value ◽

Stroke Severity ◽

Stroke Patients ◽

Urine Albumin Excretion ◽

Albumin Excretion ◽

Urine Albumin ◽

History Of

Background: Microalbuminuria is not only a predictor of subsequent kidney disease, but also an indicator of generalised endothelial injury and a manifestation of endothelial dysfunction. The present study is aimed to determine the prevalence of microalbuminuria among non–diabetic ischaemic stroke patients and find its correlation with ischaemic stroke which eventually will aid us in coming up with potent strategies to provide better prevention and cure.Methods: The present study was conducted in Department of Medicine in collaboration with Department of Biochemistry and Department of Radiology, Guru Nanak Dev Hospital, Amritsar, Punjab, India after taking approval from institutional thesis and ethical committee. The study included 60 patients (30 Cases + 30 Controls) in age group 20-80 years diagnosed as stroke and haemorrhage ruled out by NCCT Brain/MRI Brain at admission. Cases were patients with history of hypertension with acute ischaemic stroke. Controls were age and sex matched patients with no history of hypertension with acute ischaemic stroke. The microalbuminuria was assayed by immunoturbimetry. The stroke severity was assessed by NIH Stroke Severity scale. P value less than 0.05 was considered the level of significance.Results: The overall prevalence of microalbuminuria in acute ischaemic stroke patients was 41.67%. When comparing NIH SS (National Institutes of Health Stroke Scale) score with the levels of albumin in urine, there was a significant positive correlation with urinary albumin levels and stroke severity in the patients having urinary albumin levels in microalbuminuria range both in Case group and Control group with P value less than 0.05.Conclusions: Urine albumin excretion had a positive correlation with the NIH SS Score of the patient in acute ischemic stroke. Those with a higher NIH SS Score had a higher rate of urine albumin excretion and vice versa. Therefore, measurement of microalbuminuria may help to assess those who are at increased risk of severe stroke and may require a more aggressive management.

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Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

International Journal of Stroke ◽

10.1177/1747493018790059 ◽

2018 ◽

Vol 14 (1) ◽

pp. 69-79 ◽

Cited By ~ 3

Author(s):

Rufus O Akinyemi ◽

Fred S Sarfo ◽

Joshua Akinyemi ◽

Arti Singh ◽

Matthew Onoja Akpa ◽

...

Keyword(s):

Blood Pressure ◽

Genetic Testing ◽

Family History ◽

High Blood Pressure ◽

Stroke Patients ◽

Genetic Studies ◽

Attitudes And Practices ◽

Heritable Disorder ◽

History Of ◽

Knowledge Attitudes And Practices

Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

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Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis

BMC Cardiovascular Disorders ◽

10.1186/s12872-020-01677-w ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Michał Ambroziak ◽

Katarzyna Niewczas-Wieprzowska ◽

Agnieszka Maicka ◽

Andrzej Budaj

Keyword(s):

Myocardial Infarction ◽

Family History ◽

Young People ◽

Ischaemic Stroke ◽

Premature Coronary Artery Disease ◽

Premature Atherosclerosis ◽

Younger Age ◽

The Family ◽

History Of ◽

Second Degree

Abstract Background Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged < 50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI < 50). Methods The studied group (MI < 50) consisted of 240 patients aged 26–49 years with MI. The control groups consisted of 240 patients (MI ≥ 50) with MI aged 50–92 years and 240 healthy people aged 30–49 years without a history of MI (no-MI < 50). Results There were statistically significant differences between the MI < 50 and MI ≥ 50 and no-MI < 50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8, 2.9, and 3.7%, respectively; p < 0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively). Conclusions A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people. Graphical Abstract

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Coagulation Factor VII Activity, Arg/Gln353 Polymorphism and Features of Insulin Resistance in First-Degree-Relatives of South Asian Patients with Stroke

Thrombosis and Haemostasis ◽

10.1055/s-0037-1613340 ◽

2002 ◽

Vol 88 (12) ◽

pp. 9540-9560

Author(s):

Andrew Catto ◽

John Young ◽

John Bamford ◽

John Bavington ◽

Peter Grant ◽

...

Keyword(s):

Insulin Resistance ◽

Family History ◽

South Asian ◽

Coagulation Factor ◽

Plasminogen Activator Inhibitor ◽

Factor Vii ◽

Coagulation Factor Vii ◽

Control Subjects ◽

First Degree Relatives ◽

History Of

SummaryThe aim of the study was to determine associations of factor VII:C levels in 140 South Asian stroke subjects and 143 first-degree relatives versus age-sex matched 146 control subjects without a personal or a family history of stroke subjects living in UK. There were no significant differences in Factor VII:C levels or FVII Msp I gene polymorphism (Arg-Gln 353) R353Q genotype frequency between the groups. R353Q genotype determined Factor VII:C levels in all the three groups. Factor VII:C levels correlated with triglycerides (patients, r = 0.23; relatives r = 27; control subjects, r = 0.24) and plasminogen activator inhibitor activity (patients, r = 0.30; relatives r = 0.22; control subjects r = 0.20) in all the three groups, but with insulin only in patients (p = 0.19). Circulating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke.

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