Generalized low bone mass of girls with adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period

2005 ◽  
Vol 16 (9) ◽  
pp. 1024-1035 ◽  
Author(s):  
Warren T. K. Lee ◽  
Catherine S. K. Cheung ◽  
Yee Kit Tse ◽  
Xia Guo ◽  
Ling Qin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Adolescent Idiopathic Scoliosis ◽  
Bone Mass ◽  
Idiopathic Scoliosis ◽  
Calcium Intake ◽  
Weight Bearing ◽  
Low Bone Mass

Lower WNT16 expression in patients with adolescent idiopathic scoliosis – potential link to lower bone mass in AIS?

2021 ◽  
Author(s):  
KL Cheng ◽  
QQ Li ◽  
Y Wang ◽  
J Zhang ◽  
TP Lam ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Bone Mass ◽  
Idiopathic Scoliosis ◽  
Cortical Bone ◽  
Animal Study ◽  
Bone Quality ◽  
Elevated Serum ◽  
Curve Progression ◽  
Low Bone Mass ◽  
Underlying Mechanisms

Adolescent Idiopathic Scoliosis (AIS) occurs during pubertal rapid growth period and is closely associated with low bone mass. The underlying mechanisms for systemic low bone mass in AIS remains unclear. Wnt signalling pathway is one of the important pathways regulating bone metabolism and influencing bone strength, its family member Wnt16 associates with lower bone mineral density (BMD) in late adulthood, and plays key regulatory role in determining cortical bone quality in adult mice. Our randomized control trial have reported vitamin D (VitD) supplementation significantly improved bone mass and reduced the risk of curve progression in AIS. A case-control study and animal study were employed to answer if WNT16 is associated with the abnormal bone quality in AIS and if the effect of VitD supplementation is associated with Wnt16, respectively. A cohort of 161 AIS and control female subjects were recruited for measurement of anthropometric parameters, bone qualities, and circulating Wnt16 level. In animal study, WT and Wnt16 gKO mice were both subjected to special VitD diet from week 4 and terminated at week 7 and 10 for samples harvesting. AIS showed significantly lower BMD, circulating WNT16 level, and elevated serum level of type I procollagen N-terminal propeptide. Wnt16 gKO mice demonstrated lower cortical bone density compared with WT mice from week 7 of age and Wnt16 gKO were less prone to cortical bone loss induced by high dosage VitD diet. Further study on the biological role of WNT16 and crosstalk with VitD metabolism on bone qualities is warranted which might shed light on prognostic gene of osteopenia and new perspectives for potential target to prevent curve progression.

scholarly journals Calcium, physical activity and bone health – building bones for a stronger future

2001 ◽  
Vol 4 (1a) ◽  
pp. 117-123 ◽  
Author(s):  
Francesco Branca ◽  
Silvia Vatueña
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Calcium Intake ◽  
Weight Bearing ◽  
Bone Matrix ◽  
The United States ◽  
Dietary Adequacy ◽  
Enzymatic Systems ◽  
Bone Mass Measurements ◽  
Adequate Provision

AbstractAdequate provision of nutrients composing the bone matrix and regulating bone metabolism should be provided from birth in order to achieve maximal bone mass, compatible with individual genetic background, and to prevent osteoporosis later in life. Low calcium intake (<250 mg day−1) in children is associated with both a reduced bone mineral content and hyperparathyroidism. Optimal calcium intake is, however, still a matter of controversy. The minimisation of fracture risk would be the ideal functional outcome on which to evaluate lifetime calcium intakes, but proxy indicators, such as bone mass measurements or maximal calcium retention, are used instead. Calcium recommendations in Europe and the United States are based on different concepts as to requirements, leading to somewhat different interpretations of dietary adequacy. Minerals and trace elements other than calcium are involved in skeletal growth, some of them as matrix constituents, such as magnesium and fluoride, others as components of enzymatic systems involved in matrix turnover, such as zinc, copper and manganese. Vitamins also play a role in calcium metabolism (e.g. vitamin D) or as co-factors of key enzymes for skeletal metabolism (e.g. vitamins C and K). Physical activity has different effects on bone depending on its intensity, frequency, duration and the age at which it is started. The anabolic effect on bone is greater in adolescence and as a result of weight-bearing exercise. Adequate intakes of calcium appear necessary for exercise to have its bone stimulating action.

Vitamin D insufficiency and its correlation with low bone mass in adolescent idiopathic scoliosis

2013 ◽  
Author(s):  
Ping Lam Tsz ◽  
Wing Sze Yu Fish ◽  
Wah Yan Mak Queenie ◽  
Tsz Fung Cheung Franco ◽  
Man Lee Kwong ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adolescent Idiopathic Scoliosis ◽  
Bone Mass ◽  
Idiopathic Scoliosis ◽  
Vitamin D Insufficiency ◽  
Low Bone Mass

scholarly journals Minodronate treatment improves low bone mass and reduces progressive thoracic scoliosis in a mouse model of adolescent idiopathic scoliosis

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202165 ◽  
Author(s):  
Hironori Tanabe ◽  
Yoichi Aota ◽  
Yasuteru Yamaguchi ◽  
Kanichiro Kaneko ◽  
Sousuke Imai ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Mouse Model ◽  
Bone Mass ◽  
Idiopathic Scoliosis ◽  
Low Bone Mass ◽  
Thoracic Scoliosis

scholarly journals EXERCISE AND PEAK BONE MASS: RECOMMENDATION FOR BUILDING HEALTHY BONES IN CHILDREN

2016 ◽  
Vol 1 (2) ◽  
pp. 137
Author(s):  
A Andi Kurniawan
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Bone Health ◽  
Weight Status ◽  
Bone Development ◽  
Weight Bearing ◽  
Well Being ◽  
Vital Role ◽  
High Impact ◽  
Childhood And Adolescence

Regular Physical activity (PA) and exercise plays a vital role in the health and well-being of people of all ages, and its associated with positive outcomes relating to weight status, cardiometabolic markers, chronic disease prevention, bone health and mental health. Genetic factors are the strongest determinants of bone mass, but PA and exercise with loading of the bone also has a major impact on bone mass as well as on bone strength. Physical activity has been proposed as a key factor for developing healthy bones in childhood and adolescence, mainly when high-impact and weight-bearing exercise above a certain intensity and duration. It has been associated with bone accretion showing an important osteogenic effect, mainly when high-impact and weight bearing physical activity occur. Muscle mass is also a determinant of bone development. Several studies have examined the association between PA and bone health among youths.

A six years longitudinal cohort study on the changes in bone density and bone quality up to peak bone mass in adolescent idiopathic scoliosis (AIS) with and without 2 years of Calcium and Vit-D supplementation

2021 ◽  
Author(s):  
TP Lam ◽  
G Yang ◽  
H Pang ◽  
BHK Yip ◽  
WYW Lee ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Femoral Neck ◽  
Bone Mass ◽  
Idiopathic Scoliosis ◽  
Bone Health ◽  
Peak Bone Mass ◽  
Controlled Trial ◽  
Quantitative Computed Tomography ◽  
Tanner Stage ◽  
Health Improvement

Adolescent idiopathic scoliosis (AIS) is associated with osteopenia which could persist into adulthood affecting attainment of Peak Bone Mass thus resulting in osteoporosis in late adulthood. We previously reported a randomized double-blinded placebo-controlled trial(the Cal study) showing significant bone health improvement with 2-year calcium(Ca)+Vit-D supplementation for AIS girls. This study addressed the important issue whether bone health improvement from the initial 2-year Ca+Vit-D supplementation could persist as subjects approached towards Peak Bone Mass at 6-year ie after 4-year of supplement discontinuation. This was an extension of the Cal study on AIS girls (11–14 years old, mean age=12.9 years, Tanner stage<IV) with femoral neck aBMD Z-score<0 and Cobb angle≥15∘. 330 subjects were randomized to Group1(placebo), Group2(600mgCa+400-IU-Vit-D3/day) or Group3(600mgCa+800-IU-Vit-D3/day) for 2-year supplementation after which supplementation was stopped. Investigations at baseline, 2-year and 6-year included High-resolution Peripheral Quantitative Computed Tomography(HR-pQCT) at distal radius and Dual Energy X-ray Absorptiometry(DXA) at both hips. 270(81.8%) subjects completed 2-year supplementation when changes in left femoral neck aBMD, trabecular vBMD, Trabecular BV/TV, Trabecular Number and Trabecular Separation indicated significant bone health improvement with Ca+Vit-D supplementation(p<0.05). At 6-year(mean age=19.2 years), no between-group difference on bone parameters was noted except increase in Cortical Thickness being greater only in Group3 than in Group1. After 4-year supplement discontinuation, the treatment effect from the initial 2-year supplementation mostly dissipated indicating the need of continued supplementation in AIS girls to sustain therapeutic improvement on bone health as subjects approach towards Peak Bone Mass.

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