Comparison of Serum and Urine Assays for Biochemical Markers of Bone Resorption in Postmenopausal Women with and without Hormone Replacement Therapy and in Men

2000 ◽  
Vol 11 (6) ◽  
pp. 481-485 ◽  
Author(s):  
P. M. Fall ◽  
D. Kennedy ◽  
J. A. Smith ◽  
M. J. Seibel ◽  
L. G. Raisz
Keyword(s):  
Hormone Replacement Therapy ◽  
Bone Resorption ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Biochemical Markers ◽  
Hormone Replacement ◽  
Markers Of Bone Resorption ◽  
Serum And Urine

scholarly journals Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

2018 ◽  
Vol 7 (10) ◽  
pp. 297 ◽  
Author(s):  
Delia Tit ◽  
Simona Bungau ◽  
Ciprian Iovan ◽  
Delia Nistor Cseppento ◽  
Laura Endres ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Bone Resorption ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Hormone Replacement ◽  
Developed Countries ◽  
Soy Isoflavones ◽  
Control Group ◽  
Mineral Density

Postmenopausal osteoporosis is the most common form of osteoporosis and one of the major public health problems in developed countries. The prevalence of this condition, associated with the physiological stage of menopause, is continuously increasing. This study evaluated the effectiveness of soy isoflavones as compared to hormone replacement therapy (HRT) in low doses, on the prevention of postmenopausal osteoporosis, by determining bone mineral density (BMD) and urinary deoxypyridinoline (D-pyr) in physiological postmenopausal women. The study was conducted over a period of 12 months, on three parallel groups, which included a total of 325 postmenopausal women (HRT group: n = 95; phytoestrogens group: n = 124; control group: n = 106). At the one-year evaluation, we observed T-score normalization in a small number of cases (5.26%, 2.42% and 0.00%, respectively). The average values of D-Pyr decreased by 11.38% in the group treated with phytoestrogens (p < 0.05) and by 15.32% in the group that followed HRT (p < 0.05); it increased by 4.38% in the control group (p > 0.05). Both therapies have beneficial effects on bone metabolism, leading to a significant decrease in the evolution of bone resorption and there are no major differences between the efficacy of HRT and phytoestrogens in terms of the effects on BMD and bone resorption.

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