Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells

2017 ◽  
Vol 91 (9) ◽  
pp. 3175-3184 ◽  
Author(s):  
Matthieu Chevereau ◽  
Hansruedi Glatt ◽  
Daniel Zalko ◽  
Jean-Pierre Cravedi ◽  
Marc Audebert
Keyword(s):  
Metabolic Activation ◽  
Heterocyclic Amines ◽  
V79 Cells ◽  
Sulfotransferase 1A1

Role of metabolic activation by cytochrome P450 in thioacetamide-induced suppression of antibody response in male BALB/c mice

2000 ◽  
Vol 114 (1-3) ◽  
pp. 225-235 ◽  
Author(s):  
Kap-Ho Kim ◽  
Ju-Hyun Bae ◽  
Shin-Woo Cha ◽  
Sang-Seop Han ◽  
Kwan Ha Park ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Antibody Response ◽  
Metabolic Activation

scholarly journals Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells

2013 ◽  
Vol 42 (1) ◽  
pp. 162-171 ◽  
Author(s):  
Klarissa D. Hardy ◽  
Michelle D. Wahlin ◽  
Ioannis Papageorgiou ◽  
Jashvant D. Unadkat ◽  
Allan E. Rettie ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Metabolic Activation ◽  
Heparg Cells

The Role of Metabolic Activation in Target Organ Toxicity

2020 ◽  
pp. 37-54
Author(s):  
John Caldwell ◽  
Susan A. Sangster ◽  
J. David Sutton
Keyword(s):  
Metabolic Activation ◽  
Target Organ ◽  
Organ Toxicity ◽  
Target Organ Toxicity

Metabolic activation ofo-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1

Xenobiotica ◽  
2000 ◽  
Vol 30 (10) ◽  
pp. 1005-1017 ◽  
Author(s):  
S. Ozawa ◽  
K. Ohta ◽  
A. Miyajima ◽  
H. Kurebayashi ◽  
M. Sunouchi ◽  
...  
Keyword(s):  
Metabolic Activation ◽  
Human Cyp1a2

scholarly journals Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 445 ◽  
Author(s):  
Javier Mora ◽  
Christina Mertens ◽  
Julia K. Meier ◽  
Dominik C. Fuhrmann ◽  
Bernhard Brüne ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Cells ◽  
Immune Cells ◽  
Tumor Development ◽  
Metabolic Activation ◽  
Growth And Survival ◽  
Metabolic Characteristics ◽  
Inflammatory Phenotype ◽  
Tumor Outgrowth

The inflammatory tumor microenvironment is an important regulator of carcinogenesis. Tumor-infiltrating immune cells promote each step of tumor development, exerting crucial functions from initiation, early neovascularization, to metastasis. During tumor outgrowth, tumor-associated immune cells, including myeloid cells and lymphocytes, acquire a tumor-supportive, anti-inflammatory phenotype due to their interaction with tumor cells. Microenvironmental cues such as inflammation and hypoxia are mainly responsible for creating a tumor-supportive niche. Moreover, it is becoming apparent that the availability of iron within the tumor not only affects tumor growth and survival, but also the polarization of infiltrating immune cells. The interaction of tumor cells and infiltrating immune cells is multifaceted and complex, finally leading to different activation phenotypes of infiltrating immune cells regarding their functional heterogeneity and plasticity. In recent years, it was discovered that these phenotypes are mainly implicated in defining tumor outcome. Here, we discuss the role of the metabolic activation of both tumor cells and infiltrating immune cells in order to adapt their metabolism during tumor growth. Additionally, we address the role of iron availability and the hypoxic conditioning of the tumor with regard to tumor growth and we describe the relevance of therapeutic strategies to target such metabolic characteristics.

Isoform and tissue dependent impact of apolipoprotein E on adipose tissue metabolic activation: The role of apolipoprotein A1

2020 ◽  
Vol 1865 (2) ◽  
pp. 158551
Author(s):  
Christina Kalogeropoulou ◽  
Aikaterini Hatziri ◽  
Eva Xepapadaki ◽  
Odysseia Savvoulidou ◽  
Eleni A. Karavia ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Apolipoprotein E ◽  
Metabolic Activation ◽  
Apolipoprotein A1

scholarly journals In vivo Role of NAD(P)H:Quinone Oxidoreductase 1 in Metabolic Activation of Mitomycin C and Bone Marrow Cytotoxicity

2007 ◽  
Vol 67 (17) ◽  
pp. 7966-7971 ◽  
Author(s):  
Anbu Karani Adikesavan ◽  
Roberto Barrios ◽  
Anil K. Jaiswal
Keyword(s):  
Bone Marrow ◽  
Mitomycin C ◽  
Metabolic Activation
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