Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography–tandem mass spectrometry

2014 ◽  
Vol 407 (15) ◽  
pp. 4423-4435 ◽  
Author(s):  
Marilyn J. Schneider ◽  
Steven J. Lehotay ◽  
Alan R. Lightfield
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Multiresidue Method ◽  
Bovine Muscle ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Comparison of different sample preparation procedures for multiclass determination of selected veterinary drug, coccidiostat and insecticide residues in eggs by liquid chromatography-tandem mass spectrometry

2014 ◽  
Vol 6 (9) ◽  
pp. 3034-3044 ◽  
Author(s):  
Marta Piatkowska ◽  
Piotr Jedziniak ◽  
Jan Zmudzki
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Sample Preparation ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Insecticide Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

QuEChERS and zirconium-coated silica SPE in a multiresidue method for the analysis of veterinary drug residues and other contaminates in eggs by LC-MS/MS.

scholarly journals A Rapid and Easy Multiresidue Method for the Determination of Pesticide Residues in Vegetables, Fruits, and Cereals Using Liquid Chromatography/Tandem Mass Spectrometry

2008 ◽  
Vol 91 (4) ◽  
pp. 871-883 ◽  
Author(s):  
Satoshi Takatori ◽  
Masahiro Okihashi ◽  
You Okamoto ◽  
Yoko Kitagawa ◽  
Sachiko Kakimoto ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Pesticide Residues ◽  
Agricultural Products ◽  
Tandem Mass ◽  
Multiresidue Method ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Abstract The applicability of a rapid and easy multiresidue method for determination of pesticide residues in agricultural products by using liquid chromatography/tandem mass spectrometry (LC/MS/MS) was examined. Pesticide residues were extracted with acetonitrile in a disposable tube using a homogenizer, followed by salting out with anhydrous magnesium sulfate and sodium chloride. The extract was purified with a double-layered cartridge column (graphite carbon black/primary-secondary amine silica gel). After removal of the solvent, the extract was resolved in methanolwater and analyzed with LC/MS/MS. Recovery tests of 99 pesticide residues from 7 agricultural products were performed at 20 and 100 ng/g. Throughout all of the agricultural products tested, 47 pesticides exhibited satisfactory recoveries (70120) and relative standard deviations (<20) at both concentrations. The time for processing of 12 samples to test solutions was approximately 23 h. This method could be useful for determination of pesticide residues in agricultural products.

scholarly journals Quantitative Determination of Quinocetone and Its Metabolites in Chicken Plasma by Liquid Chromatography/Tandem Mass Spectrometry

2008 ◽  
Vol 91 (6) ◽  
pp. 1494-1498 ◽  
Author(s):  
Yong Li ◽  
Zhi Xian Gao ◽  
FangTing Dong ◽  
Yi Yong Cheng
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Multiple Reaction Monitoring ◽  
Veterinary Drug ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Abstract A new method has been established for the simultaneous determination of the new veterinary drug quinocetone (3-methyl-2-cinnamoyl-N-1,4-dioxyquioxaline; QTN) and its 2 metabolites de-monoxy-quinocetone (3-methyl-2-cinnamoyl-N-1-monoxyquinoxaline; DMO-QTN) and de-dioxyquinocetone (3-methyl-2-cinnamoyl-N-quinoxaline; DDI-QTN) in chicken plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The detection was performed using electrospray ionization in multiple reaction monitoring mode. The analysis of the linearity, accuracy, and precision of the method is described. The limits of detection and quantification of the LC/MS/MS method used for testing QTN, DMO-QTN, and DDI-QTN were 0.002 and 0.008 g/mL; 0.002 and 0.008 g/mL; and 0.003 and 0.010 g/mL, respectively. The method was validated and can be used in future pharmacokinetic studies.

scholarly journals Ultrasound Assisted Method Development for the Determination of Selected Sulfonamides in Honey Using Liquid Chromatography-Tandem Mass Spectrometry

2016 ◽  
Vol 16 (2) ◽  
pp. 289-295
Author(s):  
M. Manimekalai ◽  
Anand Sheshadri ◽  
K. Suresh Kumar ◽  
Ashish Rawson
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Method Development ◽  
Age Groups ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Honey is a highly valuable natural product, which is consumed by people of all age groups unaware of the high load of veterinary drug residues present. Sulfonamides are one such class of veterinary drugs, which are used in apiculture in higher amounts and impose a lot of negative health effects. This paper describes an analytical method developed for simultaneous determination of two Sulfonamides (Sulfamethizole and Trimethoprim) in honey using liquid chromatography- tandem mass spectrometry (LC-MS/MS). Suitable fragmentor voltage and collision energy were optimised for both the analytes. Five different sample preparation techniques based on ultrasonication were evaluated. In which ultrasonication at 80% amplitude, 5 minutes at 45°C gave improved recoveries. On validation, the developed method showed good linearity with r2 values in the range of 0.98-0.99 for both the sulfonamides. The effect of matrix on the method developed was evaluated and was found that the sample matrix does not pose considerable interferences with excellent linearities with r2 values above 0.95 for both the analytes. The method developed was found to be very selective and can find application in routine analysis for the determination of sulfonamides from honey samples.

Sign in / Sign up

Export Citation Format

Share Document