Norfloxacin detection based on the peroxidase-like activity enhancement of gold nanoclusters

2020 ◽  
Author(s):  
Yuying Song ◽  
Juan Qiao ◽  
Wei Liu ◽  
Li Qi
Keyword(s):  
Gold Nanoclusters ◽  
Activity Enhancement

Ultraviolet photoabsorption spectra of silver and gold nanoclusters

1998 ◽  
Vol 78 (4) ◽  
pp. 385-396 ◽  
Author(s):  
V. Kasperovich, V. V. Kresin
Keyword(s):  
Gold Nanoclusters

Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms.

2020 ◽  
Vol 27 ◽  
Author(s):  
Antonis D. Tsiailanis ◽  
Andreas G. Tzakos ◽  
Thomas Mavromoustakos
Keyword(s):  
Gold Nanoparticles ◽  
Angiotensin Ii ◽  
Therapeutic Index ◽  
Bioactive Molecules ◽  
Host Molecule ◽  
Delivery Vehicle ◽  
Metabolic Products ◽  
Activity Enhancement ◽  
Technological Platforms ◽  
Low Solubility

: Drugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases drugs, especially the highly lipophilic molecules, suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacology has provided new technological platforms, to overcome these boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II AT1 receptor (AT1R), as well as quercetin and silibinin. The encapsulation of these drugs in supramolecules or other systems refines their solubility and metabolic stability, increases their selectivity and therefore decreases their effective dose and improves the therapeutic index. In this minireview we report on the formulations of Silibinin and AT1R antagonist candesartan in a 2-HP-β-cyclodextrin host molecule, which displayed enhanced cytotoxicity and increased silibinin’s and candesartan’s stability, respectively. Moreover we describe the encapsulation of quercetin in gold nanoparticles bearing a calixarene supramolecular host. Also the encapsulation of temozolomide in a calixarene nanocapsule has been described. Finally, we report on the activity enhancement that has been achieved upon using these formulations as well as the analytical and computational methods we used to characterize these formulations and explore the molecular interactions between the host and quest molecules.

Bone Marrow Mesenchymal Stem Cell mediated Ultrasmall Gold Nanoclusters and hNIS Gene Synergize Radiotherapy in Breast Cancer

2021 ◽  
Author(s):  
Lu Zhang ◽  
Benchao Zheng ◽  
Rui Guo ◽  
Ying Miao ◽  
Biao Li
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Stem Cell ◽  
Growth Response ◽  
Sodium Iodide ◽  
Gold Nanoclusters ◽  
Early Growth ◽  
Sodium Iodide Symporter ◽  
Early Growth Response ◽  
131I Treatment

The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment. However, the...

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