Signal amplification strategies for clinical biomarker quantification using elemental mass spectrometry

2021 ◽  
Author(s):  
Andrea L. Larraga-Urdaz ◽  
Maria L. Fernandez Sanchez ◽  
Jorge Ruiz Encinar ◽  
Jose M. Costa-Fernandez
Keyword(s):  
Mass Spectrometry ◽  
Signal Amplification ◽  
Clinical Biomarker ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry

Liquid Sampling-Atmospheric Pressure Glow Discharge Ionization Source for Elemental Mass Spectrometry

2011 ◽  
Vol 83 (7) ◽  
pp. 2425-2429 ◽  
Author(s):  
R. Kenneth Marcus ◽  
C. Derrick Quarles ◽  
Charles J. Barinaga ◽  
Anthony J. Carado ◽  
David W. Koppenaal
Keyword(s):  
Mass Spectrometry ◽  
Glow Discharge ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Glow Discharge ◽  
Ionization Source ◽  
Pressure Glow Discharge ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry ◽  
Liquid Sampling

scholarly journals High-Sensitivity Elemental Mass Spectrometry of Fluorine by Ionization in Plasma Afterglow

2019 ◽  
Vol 91 (6) ◽  
pp. 3773-3777 ◽  
Author(s):  
Joseph E. Lesniewski ◽  
Kunyu Zheng ◽  
Paolo Lecchi ◽  
David Dain ◽  
Kaveh Jorabchi
Keyword(s):  
Mass Spectrometry ◽  
High Sensitivity ◽  
Plasma Afterglow ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry

scholarly journals Atomic Spectrometry Update: review of advances in the analysis of clinical and biological materials, foods and beverages

2019 ◽  
Vol 34 (3) ◽  
pp. 426-459 ◽  
Author(s):  
Andrew Taylor ◽  
Nicola Barlow ◽  
Martin P. Day ◽  
Sarah Hill ◽  
Nicholas Martin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quality Assurance ◽  
Sample Preparation ◽  
Atomic Absorption ◽  
Biological Materials ◽  
Atomic Spectrometry ◽  
Clinical Interest ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry

This review discusses developments in elemental mass spectrometry, atomic absorption, emission and fluorescence, XRF and LIBS, as applied to the analysis of specimens of clinical interest, foods and beverages. Sample preparation procedures and quality assurance are also included.

Electrospray Mass Spectrometry as a Technique for Elemental Analysis: Preliminary Results

1992 ◽  
Vol 46 (3) ◽  
pp. 401-406 ◽  
Author(s):  
George R. Agnes ◽  
Gary Horlick
Keyword(s):  
Mass Spectrometry ◽  
Elemental Analysis ◽  
Alkali Metals ◽  
Electrospray Mass Spectrometry ◽  
Low Cost ◽  
Ion Source ◽  
Preliminary Results ◽  
Background Ions ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry

Preliminary results for the analytical use of electrospray mass spectrometry (ES-MS) for elemental analysis are presented. Spectra with the declustered plus-one ion (M+) as the dominant species have been measured for the alkali metals (Li, Na, K, Rb, and Cs) and for several transition metals (Cr, Mn, Fe, Co, Ni, Cu, Zn, Ag, and Cd) in both aqueous and methanol solvents. A number of background ions are also observed including MH+, MO+, MOH+, and MOH(H2O)+. For vanadyl sulfate and uranyl nitrate, ES conditions can be adjusted to produce VO+ and UO2+ as the dominant ions in the mass spectra, indicating that direct speciation of inorganic solution components is possible. On the basis of these preliminary results, it appears that electrospray may offer a low-cost and simple generic ion source for elemental mass spectrometry.

scholarly journals Transformation of diphenylarsinic acid and related compounds in groundwater: production of thiol-containing arsenicals

2013 ◽  
Vol 10 (1) ◽  
pp. 17 ◽  
Author(s):  
Kunichika Nakamiya ◽  
Mitsuha Yoshikane ◽  
Hosoya Tomoko ◽  
Yasuyuki Shibata
Keyword(s):  
Mass Spectrometry ◽  
Environmental Problem ◽  
Environmental Fate ◽  
Chemical Warfare ◽  
Arsenic Compounds ◽  
Groundwater Samples ◽  
Molecular Mass Spectrometry ◽  
Elemental Mass ◽  
Related Compounds ◽  
Elemental Mass Spectrometry

Environmental context Contamination of groundwater by arsenic compounds used in chemical warfare research is a recently discovered environmental problem in Japan. We report evidence that the arsenic compounds originally present in the groundwater are transforming to thio-arsenic compounds of currently unknown environmental fate. Abstract During routine analyses of groundwater samples contaminated with diphenylarsinic acid (DPAA) at Kamisu, Ibaraki Prefecture, Japan, we obtained data indicating that unknown arsenic compounds accounted for up to 75% of the total arsenic in some of the samples. Results from using liquid chromatography in combination with elemental mass spectrometry and tandem molecular mass spectrometry suggested that two of the main unknown peaks were diphenyldithioarsinic acid and methylphenyldithioarsinic acid. These assignments were later confirmed by comparison with chemically synthesised compounds. A potential transformation scheme for DPAA in the environment is proposed based on the derivatives identified in the environmental samples.

Elemental mass spectrometry using a nitrogen microwave-induced plasma as an ion source

1994 ◽  
Vol 49 (9) ◽  
pp. 901-914 ◽  
Author(s):  
Konosuke Oishi ◽  
Toyoharu Okumoto ◽  
Takashi Iino ◽  
Masataka Koga ◽  
Toshihiro Shirasaki ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Source ◽  
Microwave Induced Plasma ◽  
Elemental Mass ◽  
Elemental Mass Spectrometry
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