Factors associated with adherence to drug therapy: a population-based study

(1) Background: It is not well known whether there is an association between COPD and hemorrhagic stroke (HS). We aim to analyze the incidence, clinical characteristics, procedures, and outcomes of HS in patients with and without COPD and to assess sex differences. Secondly, to identify factors associated with in-hospital mortality (IHM). (2) Methods: Patients aged ≥40 years hospitalized with HS included in the Spanish National Hospital Discharge Database (2016–2018) were analyzed. Propensity score matching (PSM) was used to compare patients according to sex and COPD status. (3) Results: We included 55,615 patients (44.29% women). Among men with COPD the HS adjusted incidence was higher (IRR 1.31; 95% CI 1.24–1.57) than among non-COPD men. COPD men had higher adjusted incidence of HS than COPD women (IRR 1.87; 95% CI 1.85–1.89). After matching, COPD men had a higher IHM (29.96% vs. 27.46%; p = 0.032) than non-COPD men. Decompressive craniectomy was more frequently conducted among COPD men than COPD women (6.74% vs. 4.54%; p = 0.014). IHM increased with age and atrial fibrillation, while decompressive craniectomy reduced IHM. (4) Conclusions: COPD men had higher incidence and IHM of HS than men without COPD. COPD men had higher incidence of HS than COPD women. Decompressive craniectomy was more frequently conducted in COPD men than COPD women and this procedure was associated to better survival.

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Trends in oral corticosteroids use in severe asthma: a 14-year population-based study

Respiratory Research ◽

10.1186/s12931-021-01696-x ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Mohsen Sadatsafavi ◽

Amir Khakban ◽

Hamid Tavakoli ◽

Solmaz Ehteshami-Afshar ◽

Larry D. Lynd ◽

...

Keyword(s):

Severe Asthma ◽

Poisson Regression ◽

Population Based ◽

Population Based Study ◽

Factors Associated ◽

Asthma Patients ◽

Oral Corticosteroids ◽

Administrative Health Databases ◽

Time Since Diagnosis

Abstract Background Oral corticosteroids are important components of pharmacotherapy in severe asthma. Our objective was to describe the extent, trends, and factors associated with exposure to oral corticosteroids (OCS) in a severe asthma cohort. Methods We used administrative health databases of British Columbia, Canada (2000–2014) and validated algorithms to retrospectively create a cohort of severe asthma patients. Exposure to OCS within each year of follow-up was measured in two ways: maintenance use as receiving on average ≥ 2.5 mg/day (prednisone-equivalent) OCS, and episodic use as the number of distinct episodes of OCS exposure for up to 14 days. Trends and factors associated with exposure on three time axes (calendar year, age, and time since diagnosis) were evaluated using Poisson regression. Results 21,144 patients (55.4% female; mean entry age 28.7) contributed 40,803 follow-up years, in 8.2% of which OCS was used as maintenance therapy. Maintenance OCS use declined by 3.8%/calendar year (p < 0.001). The average number of episodes of OCS use was 0.89/year, which increased by 1.1%/calendar year (p < 0.001). Trends remained significant for both exposure types in adjusted analyses. Both maintenance and episodic use increased by age and time since diagnosis. Conclusions This population-based study documented a secular downward trend in maintenance OCS use in a period before widespread use of biologics. This might have been responsible for a higher rate of exacerbations that required episodic OCS therapy. Such trends in OCS use might be due to changes in the epidemiology of severe asthma, or changes in patient and provider preferences over time.

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Factors associated with lower gait speed among the elderly living in a developing country: a cross-sectional population-based study

BMC Geriatrics ◽

10.1186/s12877-015-0031-2 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 37

Author(s):

Telma de Almeida Busch ◽

Yeda Aparecida Duarte ◽

Daniella Pires Nunes ◽

Maria Lucia Lebrão ◽

Michel Satya Naslavsky ◽

...

Keyword(s):

Developing Country ◽

Gait Speed ◽

The Elderly ◽

Population Based ◽

Cross Sectional ◽

Population Based Study ◽

Factors Associated ◽

Elderly Living

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Factors associated with uncontrolled hypertension and cardiovascular risk in hypertensive 60-year-old men and women—a population-based study

Hypertension Research ◽

10.1038/hr.2009.94 ◽

2009 ◽

Vol 32 (9) ◽

pp. 780-785 ◽

Cited By ~ 18

Author(s):

Axel C Carlsson ◽

Per E Wändell ◽

Gunilla Journath ◽

Ulf de Faire ◽

Mai-Lis Hellénius

Keyword(s):

Cardiovascular Risk ◽

Population Based ◽

Uncontrolled Hypertension ◽

Population Based Study ◽

Men And Women ◽

Factors Associated ◽

Old Men

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Factors associated with last dental visit or not to visit the dentist by Brazilian adolescents: A population-based study

PLoS ONE ◽

10.1371/journal.pone.0183310 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0183310 ◽

Cited By ~ 14

Author(s):

Emílio P. da Fonseca ◽

Antonio C. Frias ◽

Fábio L. Mialhe ◽

Antonio C. Pereira ◽

Marcelo de C. Meneghim

Keyword(s):

Population Based ◽

Dental Visit ◽

Population Based Study ◽

Factors Associated

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Falls among the elderly: risk factors in a population-based study

Revista Brasileira de Epidemiologia ◽

10.1590/1809-4503201400030011 ◽

2014 ◽

Vol 17 (3) ◽

pp. 705-718 ◽

Cited By ~ 9

Author(s):

Iara Guimarães Rodrigues ◽

Gustavo Pereira Fraga ◽

Marilisa Berti de Azevedo Barros

Keyword(s):

The Elderly ◽

Population Based ◽

Cross Sectional Study ◽

Cluster Sampling ◽

Elderly Adults ◽

Cross Sectional ◽

Population Based Study ◽

Factors Associated ◽

Gender And Age ◽

Policies And Programs

Purpose: The aim of the present study was to identify factors associated with the occurrence of falls among elderly adults in a population-based study (ISACamp 2008). Methods: A population-based cross-sectional study was carried out with two-stage cluster sampling. The sample was composed of 1,520 elderly adults living in the urban area of the city of Campinas, São Paulo, Brazil. The occurrence of falls was analyzed based on reports of the main accident occurred in the previous 12 months. Data on socioeconomic/demographic factors and adverse health conditions were tested for possible associations with the outcome. Prevalence ratios (PR) were estimated and adjusted for gender and age using the Poisson multiple regression analysis. Results: Falls were more frequent, after adjustment for gender and age, among female elderly participants (PR = 2.39; 95% confidence interval (95%CI) 1.47 - 3.87), elderly adults (80 years old and older) (PR = 2.50; 95%CI 1.61 - 3.88), widowed (PR = 1.74; 95%CI 1.04 - 2.89) and among elderly adults who had rheumatism/arthritis/arthrosis (PR = 1.58; 95%CI 1.00 - 2.48), osteoporosis (PR = 1.71; 95%CI 1.18 - 2.49), asthma/bronchitis/emphysema (PR = 1,73; 95%CI 1.09 - 2.74), headache (PR = 1.59; 95%CI 1.07 - 2.38), mental common disorder (PR = 1.72; 95%CI 1.12 - 2.64), dizziness (PR = 2.82; 95%CI 1.98 - 4.02), insomnia (PR = 1.75; 95%CI 1.16 - 2.65), use of multiple medications (five or more) (PR = 2.50; 95%CI 1.12 - 5.56) and use of cane/walker (PR = 2.16; 95%CI 1.19 - 3,93). Conclusion: The present study shows segments of the elderly population who are more prone to falls through the identification of factors associated with this outcome. The findings can contribute to the planning of public health policies and programs addressed to the prevention of falls.

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