Fluindione and drug reaction with eosinophilia and systemic symptoms: an unrecognised adverse effect?

2011 ◽  
Vol 68 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Amélie Daveluy ◽  
◽  
Brigitte Milpied ◽  
Annick Barbaud ◽  
Bénédicte Lebrun-Vignes ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Systemic Symptoms

scholarly journals DRESS: a rare adverse drug reaction of olanzapine

2018 ◽  
Vol 29 (2) ◽  
pp. 64-66
Author(s):  
Mohammad Monirul Islam ◽  
Md Azizul Islam ◽  
M Kumrul Hasan ◽  
Md Abdul Latif Khan
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Serum Bilirubin ◽  
Rare Complication ◽  
Urine Test ◽  
Erythematous Rash ◽  
The Face ◽  
Life Threatening ◽  
Assaultive Behavior ◽  
Systemic Symptoms

A boy of 17 years was brought by his parents with the complaints of aggressive, violent and assaultive behavior towards parents, using abusive language, demanding money, restlessness, irritability, irrelevant talk and sleep disturbance. His urine test for cannabinoid was positive. He was diagnosed as substance use disorder and was treated with olanzapine along with psychotherapy. After few days, he developed fever followed by erythematous rash with pruritus and swelling of the face, eyelids, trunk and extremities with raised serum bilirubin, ALT and alkaline phosphatase. He was diagnosed as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms), a rare complication of olanzapine. This is a dangerous and life threatening adverse effect. Early diagnosis can reduce its morbidity and mortality.Bang J Psychiatry December 2015; 29(2): 64-66

scholarly journals Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

2015 ◽  
Vol 35 (1) ◽  
pp. 73-75 ◽  
Author(s):  
NK Natt ◽  
S Tarsem ◽  
Dr Anuba ◽  
S Simarjeet ◽  
M Sharma ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Skin Rash ◽  
Drug Effect ◽  
Rapid Diagnosis ◽  
Age Group ◽  
Life Saving ◽  
Paediatric Age ◽  
Systemic Symptoms ◽  
High Index Of Suspicion

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse effect characterized by a skin rash with visceral involvement and haematological abnormalities. This adverse drug effect is often misdiagnosed and under-reported especially in paediatric age group due to its rarity and high occurrence of skin rash in various other viral illnesses of children. We report a case of DRESS in a three months old male child. A high index of suspicion, rapid diagnosis and prompt withdrawal can be life-saving for the patient.J Nepal Paediatr Soc 2015;35(1):73-75

When fever is more than infection: two cases of vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS)

2021 ◽  
Vol 14 (1) ◽  
pp. e238006
Author(s):  
Mitchell Cox ◽  
Sophie Paviour ◽  
Sophie Gregory ◽  
Rusheng Chew
Keyword(s):  
Drug Reaction ◽  
Cytomegalovirus Reactivation ◽  
First Case ◽  
Metropolitan Hospital ◽  
Orthopaedic Ward ◽  
Systemic Hypersensitivity ◽  
Systemic Symptoms ◽  
Inflammatory Syndrome ◽  
Intravenous Glucocorticoids

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, but serious systemic hypersensitivity reaction associated with a range of medications. We present two cases of vancomycin-induced DRESS, which occurred simultaneously in the orthopaedic ward in an outer metropolitan hospital. These cases demonstrate the complexity in the diagnosis and management of this inflammatory syndrome on the background of known infection as well as evidence for linezolid as an alternative to vancomycin. The first case was managed conservatively, but developed progressive renal and liver injury along with demonstrated cytomegalovirus reactivation and recurrent colitis, and was eventually palliated. The second was commenced on intravenous glucocorticoids and achieved remission, although had ongoing renal dysfunction at the time of discharge from outpatient follow-up.

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