scholarly journals Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

2015 ◽  
Vol 35 (1) ◽  
pp. 73-75 ◽  
Author(s):  
NK Natt ◽  
S Tarsem ◽  
Dr Anuba ◽  
S Simarjeet ◽  
M Sharma ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Skin Rash ◽  
Drug Effect ◽  
Rapid Diagnosis ◽  
Age Group ◽  
Life Saving ◽  
Paediatric Age ◽  
Systemic Symptoms ◽  
High Index Of Suspicion

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse effect characterized by a skin rash with visceral involvement and haematological abnormalities. This adverse drug effect is often misdiagnosed and under-reported especially in paediatric age group due to its rarity and high occurrence of skin rash in various other viral illnesses of children. We report a case of DRESS in a three months old male child. A high index of suspicion, rapid diagnosis and prompt withdrawal can be life-saving for the patient.J Nepal Paediatr Soc 2015;35(1):73-75

Sulfasalazine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) with concomitant acute chikungunya virus infection: possible role of new viral trigger

2021 ◽  
Vol 14 (10) ◽  
pp. e244063
Author(s):  
Abheek Sil ◽  
Moni Sankar Bhattacharjee ◽  
Atanu Chandra ◽  
Jayasri Das Pramanik
Keyword(s):  
Drug Reaction ◽  
Virus Infection ◽  
Renal Dysfunction ◽  
Skin Rash ◽  
Chikungunya Virus ◽  
Drug Effect ◽  
Signs And Symptoms ◽  
Viral Aetiology ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) is designated as a potentially lethal adverse drug effect with characteristic signs and symptoms such as skin rash, fever, leucocytosis with eosinophilia or atypical lymphocytes, lymphadenopathy and liver or renal dysfunction. In addition to most commonly implicated drug category (aromatic anticonvulsants), lamotrigine, sulfonamides, dapsone and abacavir may also induce this syndrome. We describe here a case a sulfasalazine-induced DRESS with coexisting chikungunya fever. The shared presentation of fever with rash in both conditions made it a challenging diagnosis. Sulfasalazine hypersensitivity manifesting as DRESS has rarely been reported. Furthermore, we document chikungunya virus (CV) as a possible triggering agent for DRESS. To the best of our knowledge, CV as a viral aetiology in DRESS has not been reported previously in the literature.

scholarly journals DRESS: a rare adverse drug reaction of olanzapine

2018 ◽  
Vol 29 (2) ◽  
pp. 64-66
Author(s):  
Mohammad Monirul Islam ◽  
Md Azizul Islam ◽  
M Kumrul Hasan ◽  
Md Abdul Latif Khan
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Serum Bilirubin ◽  
Rare Complication ◽  
Urine Test ◽  
Erythematous Rash ◽  
The Face ◽  
Life Threatening ◽  
Assaultive Behavior ◽  
Systemic Symptoms

A boy of 17 years was brought by his parents with the complaints of aggressive, violent and assaultive behavior towards parents, using abusive language, demanding money, restlessness, irritability, irrelevant talk and sleep disturbance. His urine test for cannabinoid was positive. He was diagnosed as substance use disorder and was treated with olanzapine along with psychotherapy. After few days, he developed fever followed by erythematous rash with pruritus and swelling of the face, eyelids, trunk and extremities with raised serum bilirubin, ALT and alkaline phosphatase. He was diagnosed as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms), a rare complication of olanzapine. This is a dangerous and life threatening adverse effect. Early diagnosis can reduce its morbidity and mortality.Bang J Psychiatry December 2015; 29(2): 64-66

scholarly journals Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1063
Author(s):  
Chien-Heng Lin ◽  
Sheng-Shing Lin ◽  
Syuan-Yu Hong ◽  
Chieh-Ho Chen ◽  
I-Ching Chou
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Skin Rash ◽  
Stable Condition ◽  
Anticonvulsant Drug ◽  
Dress Syndrome ◽  
Life Threatening ◽  
History Of ◽  
History Of Epilepsy ◽  
Systemic Symptoms

Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

scholarly journals Management of carbamazepine induced drug reaction with eosinophlia and systemic symptoms in Mediheal hospital-Nakuru, Kenya: a case report

2018 ◽  
Vol 4 (4) ◽  
pp. 600
Author(s):  
Ramadhan L. Mawenzi ◽  
Dhiren Parikh
Keyword(s):  
Drug Reaction ◽  
Early Recognition ◽  
Oral Prednisone ◽  
Cervical Lymphadenopathy ◽  
Maculopapular Rash ◽  
Topical Steroids ◽  
Positive Serology ◽  
Systemic Corticosteroids ◽  
Systemic Symptoms ◽  
High Index Of Suspicion

<p class="abstract">Adverse drug reactions (ADR) are undesirable events occurring as consequences of an ingested, injected or applied drug. Their spectrum can range from mild to severe reactions. Severe Cutaneous Adverse Reactions (SCARs) are diverse in presentation and in consequence. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a type of life-threatening SCAR which affects the skin as well as the internal organs. Various drugs can cause DRESS, but aromatic anticonvulsants, especially carbamazepine are considered the major culprits. The diagnosis of DRESS requires a high index of suspicion followed by an intense sign-searching clinical examination guided by established criteria. We report a previously healthy 53 year old man of Kenyan ancestry who developed fever, widespread maculopapular rash, swollen eyelids and cervical lymphadenopathy three weeks after carbamazepine. Liver enzymes were markedly elevated and he had lymphocytopenia and a positive serology for human herpes virus type 6 (HHV6). Using the RegiSCAR criteria a probable diagnosis of DRESS secondary to carbamazepine was made. His treatment involved discontinuation of the drug, intravenous hydrocortisone together with mild topical steroids. He remarkably improved and was discharged on oral prednisone and followed up for three consecutive months. The length of his hospitalisation was ten days. Carbamazepine has potential to provoke DRESS in patients of Kenyan ancestry. DRESS should be anticipated before and during use of carbamazepine for early recognition. Treatment of DRESS should involve the immediate withdrawal of offending drug and rapid initiation of systemic corticosteroids as well as application of diluted topical steroids to sooth the skin.</p>

scholarly journals Lamotrigine induced DRESS syndrome in a child: a case report and literature review

2021 ◽  
Author(s):  
Chien-Heng Lin ◽  
Sheng-Shing Lin ◽  
Syuan-Yu Hong ◽  
Chieh-Ho Chen ◽  
I-Ching Chou
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Literature Review ◽  
Skin Rash ◽  
Anticonvulsant Drug ◽  
Dress Syndrome ◽  
Life Threatening ◽  
History Of ◽  
History Of Epilepsy ◽  
Systemic Symptoms

Abstract BackgroundLamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).Case presentationHere, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in stable condition.ConclusionAnticonvulsant drugs such as lamotrigine among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

scholarly journals A Case of Drug Reaction with Eosinophilia and Systemic Symptoms

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sally Kellett ◽  
Charles Cock
Keyword(s):  
Drug Reaction ◽  
Drug Therapy ◽  
Skin Rash ◽  
Complete Resolution ◽  
Liver Enzymes ◽  
Drug Discontinuation ◽  
Systemic Involvement ◽  
Antiretroviral Therapies ◽  
Hematological Abnormalities ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterized by fever, skin rash, hematological abnormalities, and systemic involvement such as hepatitis. DRESS usually presents 2–6 weeks after drug initiation. DRESS should be suspected on clinical grounds in the setting of the introduction of new drug therapy and is most commonly described after the introduction of aromatic anticonvulsants, allopurinol, or antiretroviral therapies. We describe here a case of DRESS due to phenytoin exposure with complete resolution on drug discontinuation. Our patient developed DRESS with a skin rash, lymphadenopathy, and markedly abnormal liver enzymes, 4 weeks after drug initiation following drainage of a brain abscess. He was initially diagnosed as having a recurrence of the abscess or sepsis of another origin. It is important to recognise the possibility of DRESS in this setting, as a good outcome depends on the immediate withdrawal of the offending drug. A mortality rate of up to 10% has been described in unrecognised cases.

scholarly journals Drug reaction with eosinophilia and systemic symptoms without skin rash

2015 ◽  
Vol 47 (6) ◽  
pp. 687 ◽  
Author(s):  
Sarita Sasidharanpillai ◽  
ManikothP Binitha ◽  
Neeraj Manikath ◽  
AnishaK Janardhanan
Keyword(s):  
Drug Reaction ◽  
Skin Rash ◽  
Systemic Symptoms

Fluindione and drug reaction with eosinophilia and systemic symptoms: an unrecognised adverse effect?

2011 ◽  
Vol 68 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Amélie Daveluy ◽  
◽  
Brigitte Milpied ◽  
Annick Barbaud ◽  
Bénédicte Lebrun-Vignes ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Drug Reaction ◽  
Systemic Symptoms

scholarly journals Dapsone-induced drug reaction with eosinophilia and systemic symptoms (DRESS): the role of the primary care physician

2021 ◽  
Vol 55 (2) ◽  
pp. 169-172
Author(s):  
Blessing O Akor ◽  
Bob Ukuonu ◽  
Alexander A. Akor ◽  
Ojonugua A Ameh ◽  
Theresa Otu ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Health Centre ◽  
Final Diagnosis ◽  
Care Physician ◽  
Coordination Of Care ◽  
High Grade Fever ◽  
Systemic Symptoms ◽  
Generalized Lymphadenopathy ◽  
High Index Of Suspicion

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe adverse drug reaction with debilitating morbidity and high mortality. The interest of this presentation is to report a case of dress and the role of the healthcare coordinator (family physician) in early diagnosis, prompt treatment and coordination of care. We report a case of a 32-year-old male who was wrongly commenced on Dapsone for seizure disorder from a primary health centre. He presented two months later with a month history of severe dry cough, pleurisy, intermittent breathlessness and high-grade fever. He had a generalized pruritic rash with erythema and desquamation. There was marked oedema of the face and feet with generalized lymphadenopathy. He was jaundiced with tender hepatomegaly. He had dark coloured urine and a trace of proteinuria but normal renal function. There was marked leukocytosis (35*109/l) with eosinophilia (36%). His chest X-ray and viral screen for HBV, HCV and HIV were all negative. The multiple systemic presentations warranted a multidisciplinary review, and a final diagnosis of DRESS was made. His symptoms began to resolve within two days of withdrawal of the offending drug and commencement of oral corticosteroid with supportive care for his symptoms. At six weeks, there was a complete resolution of clinical features, and his laboratory parameters had returned to the baseline. Diagnosis of DRESS can be challenging, and a high index of suspicion is required. The multidisciplinary coordination of care by the first line physicians can also not be overemphasized for good outcomes.

Rapid detection of Rotavirus antigen in stool sample of acute diarrheic children

2012 ◽  
Vol 6 (1) ◽  
pp. 11-13
Author(s):  
Sushmita Roy ◽  
S.M. Shamsuzzaman ◽  
K.Z. Mamun
Keyword(s):  
Stool Sample ◽  
Rapid Detection ◽  
Cross Sectional Study ◽  
Rapid Diagnosis ◽  
Age Group ◽  
College Hospital ◽  
Cross Sectional ◽  
Rotavirus Infection ◽  
Medical College ◽  
Stool Samples

Rotavirus is one of the leading causes of pediatric diarrhea globally. Accurate and rapid diagnosis of Rotavirus diarrhea should reduce unnecessary use of antibiotics and ultimately reduce drug resistance. Study was designed for rapid diagnosis of Rotavirus antigen in stool sample by ICT (Immunochromatographic test) as well as to observe the seasonal variation of rotavirus infection. This cross sectional study was carried out in the department of Microbiology, Dhaka Medical College from January 2011 to December 2011. Eighty stool samples were collected from Dhaka Shishu Hospital and Dhaka Medical College Hospital. All samples were tested for rotavirus antigen by ICT. Among 80 patients, 42 (52.5%) samples were positive for rotavirus antigen. Among these 42 positive samples, 30 (71.43%) were from 0-12 months of age group, 10 (23.81%) from 13 to 24 months of age group and rest 2 (4.76%) from 25 to 36 months of age group. Rotavirus Ag was detected in stool samples from January to April and another peak episode from October to December. Considering the importance of Rotavirus associated diarrhea, rapid detection of Rotavirus infection in human is substantially needed and should be routinely practiced.DOI: http://dx.doi.org/10.3329/bjmm.v6i1.19354 Bangladesh J Med Microbiol 2012; 06(01): 11-13

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