Antiurolithiatic effect of the taraxasterol on ethylene glycol induced kidney calculi in male rats

Urolithiasis ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 419-428 ◽  
Author(s):  
Mahboubeh Yousefi Ghale-Salimi ◽  
Maryam Eidi ◽  
Nasser Ghaemi ◽  
Ramezan Ali Khavari-Nejad
Keyword(s):  
Ethylene Glycol ◽  
Male Rats ◽  
Kidney Calculi

Protective effect of ethanolic extract of Terminalia arjuna bark against ethylene glycol induced urolithiasis in male rats: In-vitro and In-Vivo evaluation

2020 ◽  
Vol 13 (12) ◽  
pp. 6132-6139
Author(s):  
Anshuman Rai ◽  
Anamika Gautam ◽  
Sakshi Panchal ◽  
Ankita Sood ◽  
Pankaj Prashar ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Male Rats ◽  
Terminalia Arjuna ◽  
In Vivo Evaluation

Chronic inhalation of ethylene glycol monoethyl ether affected the reproduction of male rats

2006 ◽  
Vol 164 ◽  
pp. S71
Author(s):  
Rui-Sheng Wang ◽  
Megumi Suda ◽  
Katsumi Ohtani
Keyword(s):  
Ethylene Glycol ◽  
Male Rats ◽  
Monoethyl Ether ◽  
Glycol Monoethyl Ether

Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

2015 ◽  
Vol 8 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Mudhir S. Shekha ◽  
Trifa F. Ismail ◽  
Falah M. Aziz
Keyword(s):  
Ethylene Glycol ◽  
Kidney Calculi ◽  
Anti Oxidant

Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed

2011 ◽  
Vol 31 (5) ◽  
pp. 506-517 ◽  
Author(s):  
IA Adedara ◽  
EO Farombi
Keyword(s):  
Vitamin E ◽  
Ethylene Glycol ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Antioxidant Systems ◽  
Sod Activity ◽  
Garcinia Kola ◽  
Monoethyl Ether ◽  
Glycol Monoethyl Ether

The present study investigated the protective effect of kolaviron, a biflavonoid from the seed of Garcinia kola, on ethylene glycol monoethyl ether (EGEE)–induced reproductive toxicity in male rats. The protective effect of kolaviron was validated using vitamin E, a standard antioxidant. EGEE was administered at a dose of 200 mg/kg. Other groups of rats were simultaneously treated with kolaviron (100 and 200 mg/kg) and vitamin E (50 mg/kg) for 14 days. EGEE treatment resulted in significant decrease in glutathione (GSH) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities but markedly increased the glutathione-S-transferase (GST) and lactate dehydrogenase (LDH) activities in the testes. In the spermatozoa, administration of EGEE caused significant decrease in the activities of CAT, GPx, GST and LDH as well as in the level of GSH but significantly increased SOD activity with concomitant increase in hydrogen peroxide and malondialdehyde levels in both testes and spermatozoa. EGEE-exposed rats showed marked testicular degeneration with concomitant decrease in spermatozoa quantity and quality. Overall, EGEE causes reproductive dysfunction in rats by altering antioxidant systems in the testes and spermatozoa. Kolaviron or vitamin E exhibited protective effects against EGEE-induced male reproductive toxicity by enhancement of antioxidant status and improvement in spermatozoa quantity and quality.

scholarly journals Comparative study of a nano-bacterial rat kidney stone model and the traditional ethylene glycol rat kidney stone model

2020 ◽  
Author(s):  
Biao Qian ◽  
Jingshen wang ◽  
Zhiqiang Hao ◽  
Yuan Wang ◽  
Heng Yang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Rat Kidney ◽  
Male Rats ◽  
The Third ◽  
The Difference ◽  
Metabolic Indices ◽  
The Sacrifice ◽  
Claudin 14

Abstract Objective To Compare a nanobacterial (NB) rat kidney stone model and the traditional ethylene glycol (EG) rat kidney stone model to assess its significance. Methods Ninety Wistar male rats were randomly divided into three groups. After the first week of modeling, three rats of every groups were randomly selected to measure the biochemical blood and urine markers. After the sacrifice, the renal tissues were observed to assess the pathological changes. The expression levels of CaSR and Claudin-14 protein were detected by kinds of technology. Results The biochemical metabolic indices of rats in NB group began to increase at the third week and decreased to normal at the 9th week. In the EG group they began to increase at the second week and did not return to normal later. At the 7th week, the creatinine levels of rats in the EG group were higher than in the NB group, and the difference was statistically significant. The formation rates of kidney stones in the NB group and EG group were 52.4 and 66.7%, respectively, but the difference of the two rates was not statistically significant. The protein expression CaSR and Claudin-14 in the EG group began to strengthen at 3rd week, and at 4th week in the NB group. CaSR was continuously expressed in the NC group, but Claudin-14 was not expressed. Conclusion The formation of stones in the NB group began slightly later. CaSR and Claudin-14 proteins play a role in the formation of kidney stones.

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