The antiurolithiasic and hepatocurative activities of aqueous extracts of Petroselinum sativum on ethylene glycol-induced kidney calculi in rats

2012 ◽  
Vol 7 (15) ◽  
Author(s):  
Saeidi Jafar
Keyword(s):  
Ethylene Glycol ◽  
Kidney Calculi ◽  
Aqueous Extracts

Antiurolithiatic effect of the taraxasterol on ethylene glycol induced kidney calculi in male rats

Urolithiasis ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 419-428 ◽  
Author(s):  
Mahboubeh Yousefi Ghale-Salimi ◽  
Maryam Eidi ◽  
Nasser Ghaemi ◽  
Ramezan Ali Khavari-Nejad
Keyword(s):  
Ethylene Glycol ◽  
Male Rats ◽  
Kidney Calculi

Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

2015 ◽  
Vol 8 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Mudhir S. Shekha ◽  
Trifa F. Ismail ◽  
Falah M. Aziz
Keyword(s):  
Ethylene Glycol ◽  
Kidney Calculi ◽  
Anti Oxidant

scholarly journals Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1317
Author(s):  
Osama M. Ahmed ◽  
Hossam Ebaid ◽  
El-Shaymaa El-Nahass ◽  
Mahmoud Ragab ◽  
Ibrahim M. Alhazza
Keyword(s):  
Ethylene Glycol ◽  
Serum Creatinine ◽  
Pleurotus Ostreatus ◽  
Agaricus Bisporus ◽  
Urine Specific Gravity ◽  
Aqueous Extracts ◽  
Serum Urea ◽  
Urinary Creatinine ◽  
Apoptosis Pathways ◽  
Extrinsic Apoptosis

This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts and carvedilol on hyperoxaluria-induced urolithiasis and to scrutinize the possible roles of NF-κB, p53, Bcl-2, Bax and Bak. Phytochemical screening and GC-MS analysis of mushrooms’ aqueous extracts were also performed and revealed the presence of multiple antioxidant and anti-inflammatory components. Hyperoxaluria was induced in Wistar rats through the addition of 0.75% (v/v) ethylene glycol in drinking water for nine weeks. The ethylene glycol-administered rats were orally treated with Pleurotus ostreatus and Agaricus bisporus aqueous extracts (100 mg/kg) and carvedilol (30 mg/kg) daily during the last seven weeks. The study showed that Pleurotus ostreatus, Agaricus bisporus and carvedilol all successfully inhibited ethylene glycol-induced histological perturbations and the elevation of serum creatinine, serum urea, serum and urinary uric acid, serum, urinary and kidney oxalate, urine specific gravity, kidney calcium, kidney NF-κB, NF-κB p65, NF-κB p50, p53, Bax and Bak expressions as well as serum TNF-α and IL-1β levels. Moreover, the treatment decreased the reduction in urinary creatinine, urinary urea, ratios of urinary creatinine to serum creatinine and urinary urea to serum urea, Fex Urea and Bcl-2 expression in kidney. In conclusion, although Pleurotus ostreatus and Agaricus bisporus extracts and carvedilol all significantly inhibited the progression of nephrolithiasis and showed nephroprotective effects against ethylene glycol-induced kidney dysfunction, Pleurotus ostreatus and Agaricus bisporus seemed to be more effective than carvedilol. Moreover, the nephroprotective effects may be mediated via affecting NF-κB activation, extrinsic apoptosis and intrinsic apoptosis pathways.

scholarly journals The preventive effect of N-butanol fraction of Nigella sativa on ethylene glycol-induced kidney calculi in rats

2011 ◽  
Vol 7 (28) ◽  
pp. 338 ◽  
Author(s):  
AbolfazlKhajavi Rad ◽  
Maryam Tehranipour ◽  
Mousa-Al-Reza Hadjzadeh ◽  
Ziba Rajaei ◽  
Nahid Monavar
Keyword(s):  
Ethylene Glycol ◽  
Nigella Sativa ◽  
Kidney Calculi ◽  
Preventive Effect ◽  
Butanol Fraction

scholarly journals The Effect of Alcoholic Extract of Smyrnium cordifolium Boiss Root on Prevention of Ethylene Glycol-Induced Kidney Calculi in Rats

2016 ◽  
Vol 24 (2) ◽  
pp. 130-138
Author(s):  
Mahbobeh Adhamian esfehani ◽  
leila Rouhi ◽  
Shahrzad Azizi ◽  
◽  
◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Kidney Calculi ◽  
Alcoholic Extract

scholarly journals Lithotriptic Effects of Phyllanthus fraternus Methanol Leaf Extract on Ethylene Glycol-induced Kidney Calculi in Albino Rats

2021 ◽  
pp. 26-34
Author(s):  
I. J. Omeh ◽  
M. S. Nadro
Keyword(s):  
Body Weight ◽  
Ethylene Glycol ◽  
Normal Control ◽  
Leaf Extract ◽  
Calcium Phosphates ◽  
Control Group ◽  
Albino Rats ◽  
Kidney Calculi ◽  
Body Weights ◽  
Phyllanthus Fraternus

This study was designed to evaluate the Lithotriptic potentials of Phyllantus fraternus methanol leaf extract on ethylene glycol-induced kidney calculi in albino rats. Ethylene glycol (1% v/v) was administered in their drinking water for a period of 28 days. The Treatment was done with the extract at 200 mg/kg, 400 mg/kg and 600 mg/kg body weights. Cystone® at 500 mg/kg body weight was also given for a period of 21 days to the standard control group. The serum parameters such as calcium, phosphates, magnesium and albumin were measured and evaluated. The results for the Lithotriptic activity, where the kidney homogenates were analyzed are described as thus, the phosphate concentrations when compared were significant (p<0.05) between the groups’ 600 mg/kg body weight (9.61 ± 1.17) and the normal control (5.67 ± 0.70). Significant differences (p<0.05) for phosphates were also observed between 600 mg/kg (9.61 ± 1.17) and 200 mg/kg body weights (12.06 ± 0.51); 400 mg/kg (7.64 ± 0.44) and 200 mg/kg body weights (12.06 ± 0.51) and the 200 mg/kg and standard control groups Cystone® (7.96 ± 0.56) respectively. Significant differences (p<0.05) were also observed for phosphates concentration, when the normal control (5.67 ± 0.70) was compared to the 400 mg/kg body weight (7.64 ± 0.44) and the standard control group Cystone® (7.96 ± 0.56). From this study, it can be deduced that, the presented data indicated that, the administration of Phyllanthus fraternus methanol leaf extract to rats with ethylene glycol-induced kidney calculi, reduced and prevented the growth of kidney calculi, supporting the folklore claim regarding its Lithotriptic activity.

scholarly journals Therapeutic effects of aerial parts of Smyrnium cordifolium ethanolic extract on ethylene glycol-induced kidney calculi in rats

2018 ◽  
Vol 5 (4) ◽  
pp. 14-21
Author(s):  
Zohreh Dovodizadeh ◽  
Leila Rouhi ◽  
Shahrzad Azizi ◽  
◽  
◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Ethanolic Extract ◽  
Kidney Calculi ◽  
Therapeutic Effects ◽  
Aerial Parts

The inhibitory effect of an ethanol extract of the spores of Lygodium japonicum on ethylene glycol-induced kidney calculi in rats

Urolithiasis ◽  
2014 ◽  
Vol 42 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Hyuk Jin Cho ◽  
Woong Jin Bae ◽  
Su Jin Kim ◽  
Sung Hoo Hong ◽  
Ji Youl Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Kidney Calculi ◽  
Lygodium Japonicum

scholarly journals Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats

BMC Genomics ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Yanan Cao ◽  
Xiaowei Gao ◽  
Yue Yang ◽  
Zhi Ye ◽  
E. Wang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Expression Profiles ◽  
Circular Rnas ◽  
Kidney Calculi ◽  
Non Coding Rnas
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