Inhibitory effect of bikunin on calcium oxalate crystallization in vitro and urinary bikunin decrease in renal stone formers

1999 ◽  
Vol 27 (1) ◽  
pp. 69-75 ◽  
Author(s):  
J. Médétognon-Benissan ◽  
S. Tardivel ◽  
C. Hennequin ◽  
M. Daudon ◽  
T. Drüeke ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Renal Stone ◽  
Inhibitory Effect ◽  
Calcium Oxalate Crystallization ◽  
Stone Formers

scholarly journals In Vitro Effect of Wheat Bran (Triticum aestivum) Extract on Calcium Oxalate Urolithiasis Crystallization

2011 ◽  
Vol 6 (10) ◽  
pp. 1934578X1100601
Author(s):  
Khaled Sekkoum ◽  
Abdelkrim Cheriti ◽  
Safia Taleb
Keyword(s):  
Triticum Aestivum ◽  
Calcium Oxalate ◽  
Wheat Bran ◽  
Triticum Aestivum L ◽  
Inhibitory Effect ◽  
Calcium Oxalate Crystallization ◽  
Inhibiting Effect ◽  
Polarized Microscopy ◽  
Vitro Effect

Urolithiasis can lead to the loss of renal function in some cases. In this study, we tested the inhibiting effect of wheat bran ( Triticum aestivum L) extract on calcium oxalate crystallization in a turbidimetric model, by FTIR spectroscopy, and polarized microscopy. The results show that this plant extract has a major inhibitory effect on calcium oxalate crystallization.

scholarly journals THE INHIBITORY EFFECT OF KAMPOU EXTRACTS ON IN VITRO CALCIUM OXALATE CRYSTALLIZATION AND IN VIVO STONE FORMATION IN AN ANIMAL MODEL

1995 ◽  
Vol 2 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Takuo Koide ◽  
Seiji Yamaguchi ◽  
Masato Utsunomiya ◽  
Toshiaki YoshiokaY ◽  
Kiyoshi Sugiyawia
Keyword(s):  
Animal Model ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Inhibitory Effect ◽  
Calcium Oxalate Crystallization

Circadian Periodicity of Urinary Inhibitor of Calcium Oxalate Crystallization in Healthy Indians and Renal Stone Formers

1993 ◽  
Vol 24 (3) ◽  
pp. 387-392 ◽  
Author(s):  
R.K. Singh ◽  
A. Bansal ◽  
S.K. Bansal ◽  
A.K. Singh ◽  
A.A. Mahdi
Keyword(s):  
Calcium Oxalate ◽  
Renal Stone ◽  
Circadian Periodicity ◽  
Calcium Oxalate Crystallization ◽  
Stone Formers

Expression of proteins that inhibit calcium oxalate crystallization in vitro in the urine of normal and stone-forming individuals

2001 ◽  
Vol 37 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Ryan C. Hedgepeth ◽  
Lizhu Yang ◽  
Martin I. Resnick ◽  
Susan Ruth Marengo
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Crystallization

Abnormal Erythrocyte and Renal Frusemide-Sensitive Sodium Transport in Idiopathic Calcium Nephrolithiasis

1994 ◽  
Vol 86 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Bruno Baggio ◽  
Giovanni Gambaro ◽  
Francesco Marchini ◽  
Massimo Vincenti ◽  
Giulio Ceolotto ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Renal Stone ◽  
Stone Formation ◽  
Fractional Excretion ◽  
Cation Transport ◽  
Anion Transport ◽  
Kinetic Properties ◽  
Distal Nephron ◽  
Stone Formers ◽  
Na Efflux

1. Anomalous transmembrane anion transport has been observed in erythrocytes of patients with idiopathic calcium nephrolithiasis. 2. To verify whether cation transport is also abnormal, we investigated the frusemide-sensitive Na+ efflux from Na+-loaded erythrocytes and the natriuretic response to acute intravenous frusemide administration in calcium oxalate renal stone formers. 3. Frusemide administration induced a statistically significant smaller increase in the fractional excretion of Na+ in patients than in control subjects. Abnormal kinetic properties of erythrocyte Na+-K+-2Cl− co-transport were observed in approximately 60% of stone formers. The Km for Na+ of Na+-K+-2Cl− co-transport correlated with urinary Ca2+ excretion. 4. The abnormal kinetic properties of Na+-K+-2Cl− co-transport may be relevant for stone formation, hampering renal Ca2+ reabsorption in the distal nephron and determining critical physicochemical conditions for calcium/oxalate crystallization.

scholarly journals In Vivo Entombment of Bacteria and Fungi during Calcium Oxalate, Brushite and Struvite Urolithiasis

Kidney360 ◽  
2020 ◽  
pp. 10.34067/KID.0006942020
Author(s):  
Jessica J. Saw ◽  
Mayandi Sivaguru ◽  
Elena M. Wilson ◽  
Yiran Dong ◽  
Robert A. Sanford ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Human Kidney ◽  
Rrna Gene ◽  
Bacterial Cells ◽  
Stone Formers ◽  
Bacteria And Fungi ◽  
Struvite Stones

Background: Human kidney stones form via repeated events of mineral precipitation, partial dissolution and reprecipitation, which are directly analogous to similar processes in other natural and man-made environments where resident microbiomes strongly influence biomineralization. High-resolution microscopy and high-fidelity metagenomic (microscopy-to-omics) analyses, applicable to all forms of biomineralization, have been applied to assemble definitive evidence of in vivo microbiome entombment during urolithiasis. Methods: Stone fragments were collected from a randomly chosen cohort of 20 patients using standard percutaneous nephrolithotomy (PCNL). Fourier transform infrared (FTIR) spectroscopy indicated that 18 of these patients were calcium oxalate (CaOx) stone formers, while one patient each formed brushite and struvite stones. This apportionment is consistent with global stone mineralogy distributions. Stone fragments from 7 of these 20 patients (5 CaOx, 1 brushite and 1 struvite) were thin sectioned and analyzed using brightfield (BF), polarization (POL), confocal, superresolution autofluorescence (SRAF) and Raman techniques. DNA from remaining fragments, grouped according to each of the 20 patients, were analyzed with amplicon sequencing of 16S rRNA gene sequences (V1-V3, V3-V5) and internal transcribed spacer (ITS1, ITS2) regions. Results: Bulk entombed DNA was sequenced from stone fragments in 11 of the 18 CaOx patients, as well as the brushite and struvite patients. These analyses confirmed the presence of an entombed low-diversity community of bacteria and fungi, including Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Aspergillus niger. Bacterial cells ~1  µm in diameter were also optically observed to be entombed and well-preserved in amorphous hydroxyapatite spherules and fans of needle-like crystals of brushite and struvite. Conclusions: These results indicate a microbiome is entombed during in vivo CaOx stone formation. Similar processes are implied for brushite and struvite stones. This evidence lays the groundwork for future in vitro and in vivo experimentation to determine how the microbiome may actively and/or passively influence kidney stone biomineralization.

The Effect of Ethane-1-Hydroxy-1,1-Diphosphonate (EHDP) on Calcium Oxalate Crystalluria in Recurrent Renal Stone-Formers

1974 ◽  
Vol 47 (1) ◽  
pp. 13-22 ◽  
Author(s):  
W. G. Robertson ◽  
M. Peacock ◽  
R. W. Marshall ◽  
F. Knowles
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Basal Diet ◽  
Sodium Oxalate ◽  
Calcium Oxalate Crystals ◽  
Calcium Oxalate Dihydrate ◽  
Calcium Oxalate Stone ◽  
Oxalate Crystals ◽  
Stone Formers

1. The volume, size and type of calcium oxalate crystals excreted in the urine of a group of patients with recurrent ‘idiopathic’ stones were studied on a controlled basal diet, after an oral supplement of sodium oxalate and after oral administration of ethane-1-hydroxy-1,1-diphosphonate (EHDP) for 4 weeks. 2. Before administration of EHDP the stone-formers passed the large crystals and aggregates of calcium oxalate dihydrate characteristic of recurrent calcium oxalate stone-formers. For the same level of urine saturation and crystalluria EHDP caused a significant reduction in the proportion of large crystals and aggregates excreted. Studies by light-microscopy confirmed that EHDP caused a striking change in the size and habit of calcium oxalate crystals in some but not all of the urine samples examined. 3. The decrease in average crystal size during the administration of EHDP was attributed to the observed increase in the ability of urine to inhibit the growth and aggregation of calcium oxalate crystals as measured by a growth system in vitro. 4. The possible use of EHDP as a therapeutic agent in the treatment of calcium oxalate stone-formation is discussed.

scholarly journals In vitro effects on calcium oxalate crystallization kinetics and crystal morphology of an aqueous extract from Ceterach officinarum: Analysis of a potential antilithiatic mechanism

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218734 ◽  
Author(s):  
Roberta De Bellis ◽  
Maria Piera Piacentini ◽  
Maria Assunta Meli ◽  
Michele Mattioli ◽  
Michele Menotta ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Crystallization Kinetics ◽  
Aqueous Extract ◽  
Crystal Morphology ◽  
Calcium Oxalate Crystallization ◽  
In Vitro Effects
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