scholarly journals Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative

2021 ◽  
Author(s):  
Kalpana Sharma ◽  
Felix Eckstein ◽  
Wolfgang Wirth ◽  
Katja Emmanuel
Keyword(s):  
Knee Osteoarthritis ◽  
Medial Meniscus ◽  
Lateral Meniscus ◽  
Cartilage Thickness ◽  
Cohen’S D ◽  
Structural Progression ◽  
Osteoarthritis Initiative ◽  
Cohen's D ◽  
Meniscus Extrusion ◽  
Central Slice

Abstract Objective To explore whether and which quantitative 3D measures of medial and/or lateral meniscus position and size are associated with subsequent medial femorotibial structural progression of knee osteoarthritis and to determine the correlation between central slice and total meniscus measures. Materials and Methods Knees with radiographic osteoarthritis from Osteoarthritis Initiative participants with longitudinal medial MRI-based cartilage thickness and radiographic joint space width (JSW) loss over 12 months were selected. These 37 structural progressor knees (64.7 ± 8.0y, 30.2 ± 4.6 kg/m2, 35% men) were matched 1:1 to 37 non-progressor knees (64.6 ± 9.8y, 30.2 ± 4.4 kg/m2, 35% men) without cartilage thickness or JSW loss. Quantitative measures of meniscus position and size were computed from manual segmentations of coronal baseline MRIs. Cohen’s D was used as measure of effect size. Results Maximum extrusion distance of the total medial meniscus and mean extrusion in the central 5 and in the central slice were greater for progressor than non-progressor knees (Cohen’s D 0.58–0.66). No significant differences were observed for medial tibial coverage or mean extrusion (entire meniscus). Among medial meniscus morphology measures, only mean height differed between progressor vs non-progressor knees (Cohen’s D 0.40). Among lateral meniscus measures, height and volume were greater in progressor vs. non-progressor knees (Cohen’s D 0.46–0.83). Mean extrusion measures were highly correlated between the entire meniscus and the central (r = 0.88) or the central 5 (r = 0.93) slices. Conclusions 3D maximum and central medial meniscus extrusion may serve as predictors for subsequent structural progression. Central meniscus extrusion measures could substitute 3D extrusion measurement across the entire meniscus.

scholarly journals The Effect of Extensor Muscle Strength on Meniscus Progression in Subjects Without Radiologic Knee Osteoarthritis -- Data From the Osteoarthritis Initiative

2021 ◽  
Author(s):  
Mingyang Li ◽  
Yong Nie ◽  
Kang Li ◽  
Yi Zeng ◽  
Yuangang Wu ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Knee Osteoarthritis ◽  
Medial Meniscus ◽  
Lateral Meniscus ◽  
High Strength ◽  
Extensor Muscle ◽  
Strength Group ◽  
Structural Progression ◽  
Significant Difference ◽  
Osteoarthritis Initiative

Abstract BackgroundHigh extensor strength decreased knee osteoarthritis symptomatic progression in female was well demonstrated. However, few studies detected a significant association between extensor strength and structural progression when joint space narrowing or cartilage loss were the indicators. The pathological change in meniscus could come earlier than that in cartilage and JSN, but no studies have specifically investigated the association between extensor strength and meniscus progression. MethodsParticipants in Osteoarthritis Initiative with both muscle strength and meniscus assessment, KL grade ≤ 1, and BMI < 30, were enrolled. In separate-sex analysis, participants were divided into the high strength group and the low strength group referring to the median baseline maximum extensor muscle strength/weight. Overall and classified meniscus progression in MRI Osteoarthritis Knee Score was compared between the two groups, at 12 months (622 knees) and 24 months (548 knees). ResultsIn females, less overall medial meniscus progression (11.1% [17/153] VS 23.2% [32/138], P=0.04), less medial meniscal medially extrusion (5.2 % [8/155] VS 12.5 % [18/144], P =0.04), and less medial meniscal anteriorly extrusion progression (0 % [0/108] VS 5.3% [6/113], P=0.03), was presented in the high strength group over 24 months. No significant difference was detected in other comparisons (in males, or in lateral meniscus, or in 12 months). Conclusion High baseline extensor strength in females was associated with a decreased risk of 24- month medial meniscus progression. High extensor strength does not only correlate with less symptomatic progression of KOA, but also with lower risk of structural progression.

scholarly journals Efficacy and safety of sprifermin injection for knee osteoarthritis treatment: a meta-analysis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Ni Zeng ◽  
Xin-Yuan Chen ◽  
Zhi-Peng Yan ◽  
Jie-Ting Li ◽  
Tao Liao ◽  
...  
Keyword(s):  
Adverse Events ◽  
Knee Osteoarthritis ◽  
Meta Analysis ◽  
Placebo Treatment ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Random Effects Models ◽  
Structural Progression ◽  
Significant Difference ◽  
Mean Differences

Abstract Objective To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment for patients with knee osteoarthritis (KOA). Method We systematically searched the literature for studies that compared long-term outcomes between sprifermin and placebo injections for KOA treatment. Meta-analysis was performed with RevMan5.3 using an inverse variance approach with fixed or random effects models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Results Eight studies were included. Overall, there was significantly less improvement of WOMAC total scores in patients receiving sprifermin, compared with the placebo (mean difference (MD) = 3.23, 95% CI 0.76–5.69; I2 = 0%; P = 0.01). Further, sprifermin injection patients gained more, and lost less, cartilage thickness and volume in total femorotibial joint (cartilage thickness: standardized mean differences (SMD) = 0.55, 95% CI 0.26–0.84; I2 = 78%; P = 0.0002; cartilage volume: SMD = 0.39, 95% CI 0.20–0.58; I2 = 49%; P < 0.0001). Changes in the cartilage surface morphology of the medial tibio-femoral joint (MD = −0.30, 95% CI −0.44 to −0.16; I2 = 0%; P < 0.0001) and patello-femoral joint (MD = −0.22; 95% CI −0.37 to −0.07; I2 = 0%; P = 0.004) showed a significant difference between the sprifermin and placebo injections. Moreover, there were no significant differences between sprifermin and the placebo in the risk of treatment-emergent adverse events (OR = 1.05; 95% CI 0.52–2.14; I2 = 48%; P = 0.89). Conclusion The data from the included studies provide strong evidence to determine the effect of intra-articular sprifermin on joint structure in individuals with KOA and show no specific adverse effects. Nevertheless, intra-articular sprifermin did not likely have any positive effect on symptom alleviation.

Fully automatic three-dimensional MRI analysis for the cartilage and meniscus of the knee: Kanagawa Knee Study

2020 ◽  
Author(s):  
Hayato Aoki ◽  
Nobutake Ozeki ◽  
Hisako Katano ◽  
Akinobu Hyodo ◽  
Junpei Matsuda ◽  
...  
Keyword(s):  
Lateral Meniscus ◽  
Three Dimensional ◽  
Cross Sectional Study ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Similarity Coefficients ◽  
Cross Sectional ◽  
Coverage Ratio ◽  
Fully Automatic ◽  
Meniscus Extrusion

Abstract Objective We have developed a fully automatic three-dimensional MRI analysis software that measures the projected cartilage area ratio (PCAR) to allow for the quantification of the cartilage in the knee. Our objectives for this cross-sectional study were to verify our software’s accuracy and to quantify cartilage and meniscus extrusion. We also examined which cartilage quantification was most affected by age and analyzed the relationship between PCAR and meniscus extrusion. Methods 108 subjects were selected for training, and Dice similarity coefficients were determined from 5 other subjects. This study included 561 subjects between 30–70 years of age. From their knee MRI data, we quantified cartilage thickness, cartilage volume, and PCAR (0.0–1.5 mm) in four regions, including the medial tibial (MT) cartilage. Furthermore, each region was divided into nine subregions. The medial central (mc) subregion was also analyzed. As a quantification for meniscus extrusion, the medial meniscus coverage ratio (MMCR) was also investigated. Results Dice similarity coefficients were 0.911 and 0.892 for the femoral and tibial cartilage and 0.916 and 0.891 for the medial and lateral meniscus. Among 48 cartilage quantifications, the highest absolute value of the correlation coefficient with age was mcMT PCAR 1.0 mm in females and mcMT cartilage thickness in males. In females, mcMT PCAR 1.0 mm was correlated with MMCR, although MMCR was not correlated with age. In males, mcMT PCAR 0.0 mm was correlated with MMCR. Conclusions Our software showed high segmentation accuracy and provided numerous quantifications of cartilage related to age and meniscus extrusion.

US detection of medial meniscus extrusion can predict the risk of developing radiographic knee osteoarthritis: a 5-year cohort study

2020 ◽  
Vol 30 (7) ◽  
pp. 3996-4004
Author(s):  
Daisuke Chiba ◽  
Eiji Sasaki ◽  
Seiya Ota ◽  
Shugo Maeda ◽  
Daisuke Sugiyama ◽  
...  
Keyword(s):  
Cohort Study ◽  
Knee Osteoarthritis ◽  
Medial Meniscus ◽  
Medial Meniscus Extrusion ◽  
Meniscus Extrusion ◽  
Radiographic Knee Osteoarthritis

scholarly journals The Association between Dietary Magnesium Intake and Magnetic Resonance Parameters for Knee Osteoarthritis

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1387 ◽  
Author(s):  
Nicola Veronese ◽  
Luciana La Tegola ◽  
Maria Gabriella Caruso ◽  
Stefania Maggi ◽  
Giuseppe Guglielmi
Keyword(s):  
Knee Osteoarthritis ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Cross Sectional ◽  
Knee Oa ◽  
Dietary Magnesium ◽  
Magnetic Resonance Parameters ◽  
Osteoarthritis Initiative

The aim of the study was to evaluate the relationship between dietary magnesium (Mg) intake and prevalence of knee osteoarthritis (OA), a topic poorly explored in the literature. Overall, 783 people participating in the Osteoarthritis Initiative (59.8% females; mean age: 62.3 years) and having an MRI assessment were enrolled in this cross-sectional study. Mg intake was measured with a semi-quantitative food frequency questionnaire, and its association with knee OA was evaluated for an increased intake of 100 mg/day. Using an adjusted linear regression analysis, a higher Mg intake (i.e., increase of 100 mg/day) corresponded to a significant increase in mean cartilage thickness, cartilage volume at medial tibia, cartilage volume and mean cartilage thickness at central medial femur, and cartilage volume and mean cartilage thickness in the central medial tibiofemoral compartment. In conclusion, an increased Mg dietary intake is associated with a better knee cartilage architecture, also when adjusting for potential confounders, suggesting a potential role of Mg in the prevention and treatment of knee OA.

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