Intramedullary chondroid tumors of bone: correlation of abnormal peritumoral marrow and soft-tissue MRI signal with tumor type

1997 ◽  
Vol 26 (2) ◽  
pp. 100-106 ◽  
Author(s):  
L. Janzen ◽  
P. M. Logan ◽  
J. X. O'Connell ◽  
D. G. Connell ◽  
P. L. Munk
Keyword(s):  
Soft Tissue ◽  
Tumor Type ◽  
Tumors Of Bone

scholarly journals Ultrasound Ablation: New Possibilities for Treatment of Bone and Soft-Tissue Tumors

2010 ◽  
Vol 17 (2) ◽  
pp. 41-49
Author(s):  
G I Nazarenko ◽  
V Sh Chen ◽  
A N Khitrova
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Secondary Infection ◽  
Local Treatment ◽  
Soft Tissue Tumors ◽  
Treatment Technique ◽  
Tumor Type ◽  
Coagulative Necrosis ◽  
Ultrasound Ablation ◽  
Physical Principles

Focused high intensity ultrasound (HIFU) with sighting influence on tumor enabled to cause its complete coagulative necrosis without damage to intact environmental tissues. The possibilities of ultrasound ablation as the method of local treatment of bone and soft-tissue tumor were considered. Physical principles of method, criteria for patient selection, treatment technique as well as clinical outcomes and their evaluation were presented. Advantages of method are non-invasiveness, less traumatization, less technical complexity and dependence on surgeon skill compared with other sparing operations and methods of ablation. When necessary HIFU may be repeated several times. Effect of HIFU is independent on tumor type. Possible complications (secondary infection in coagulative necrosis zone, peripheral nerves damage, pathological fractures) and measures of their prevention are presented.

scholarly journals How Can a Multidisciplinary Approach Improve Prognosis of Soft-Tissue Sarcomas of Extremities?

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Asmae Mazti ◽  
Mohamed El Idrissi ◽  
Abdelhalim El Ibrahimi ◽  
Mustapha El Maaroufi ◽  
Ghizlane El Koubaiti ◽  
...  
Keyword(s):  
Survival Rate ◽  
Soft Tissue ◽  
Malignant Tumors ◽  
Research Work ◽  
Soft Tissue Sarcomas ◽  
University Hospital ◽  
R0 Resection ◽  
Magnetic Resonance Imaging Scan ◽  
Tumor Type ◽  
Multidisciplinary Meeting

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. During this research work, 116 cases were selected with an average age of 53 years. In 95.7% of the cases, it was found that the lower limb was the most frequent tumor type (78.4%). Also, ninety-two (92) patients (79.3%) have had a prior biopsy. Ninety-nine (99) patients (85.3%) have received a magnetic resonance imaging scan (MRI) before surgery. Sixty-three (63) patients were operated on, including R0 resection used for 37 patients, R1 used for 21 patients, and R2 used for five patients. As a result, liposarcomas were the most frequent type (30.1%), followed by synovial sarcomas (14.6%), leiomyosarcomas (9.5%), ewing sarcoma (8.6), and undifferentiated pleomorphic sarcomas (7.7%). In addition, neoadjuvant chemotherapy was used for 36 patients. The other 22 patients received adjuvant chemotherapy and/or radiotherapy. The overall survival rate was 60.56 months, which proves a significant improvement, thanks to the multidisciplinary meeting approach. Conclusion. The conducted investigation has shown that using MDM for managing soft-tissue sarcomas of extremities improves the patients’ survival rate. Moreover, results have proven MDM might allow optimal treatment regarding less local recurrence and metastasis.

Perioperative blood transfusions are associated with increased rates of recurrence and decreased survival in patients with high-grade soft-tissue sarcomas of the extremities.

1985 ◽  
Vol 3 (5) ◽  
pp. 698-709 ◽  
Author(s):  
S A Rosenberg ◽  
C A Seipp ◽  
D E White ◽  
R Wesley
Keyword(s):  
Soft Tissue ◽  
Tumor Recurrence ◽  
Soft Tissue Sarcomas ◽  
Primary Lesion ◽  
Blood Transfusions ◽  
Tumor Type ◽  
High Grade ◽  
Anatomic Site ◽  
The Impact ◽  
Disease Free

One hundred fifty-six patients with high-grade soft-tissue sarcomas of the extremities treated on prospective randomized trials were analyzed to determine the impact of perioperative blood transfusions on tumor recurrence and patient survival. A significant increase in the incidence of tumor recurrence and decrease in survival were associated with the receipt of blood transfusions at the time of definitive surgical therapy of the sarcoma. Actuarial 5-year continuous disease-free survival was 70% in patients who had not been transfused compared to 48% in patients who received one or more transfusions (P = .007). Overall 5-year survival was also substantially decreased in patients receiving transfusions (85% compared to 63%; P = .0035). A direct relationship existed between the number of transfusions administered and the decrease in disease-free and overall survival; the larger the number of transfusions the worse the prognosis (P less than .0001 and P = .0001, respectively). A large number of other prognostic factors were included in the analysis including the age, sex, race of the patient, histology of the primary lesion, anatomic site of the primary lesion, final surgical margins, size of the tumor, type of surgery required, the use of chemotherapy, actual time in the operating room under anesthesia, the exact anesthetic agent used, and the individual surgeon who performed the operation. Accounting for all of these factors a strong association continued to exist between the receipt of blood transfusion and poor patient prognosis. We have previously shown that adjuvant chemotherapy is of benefit to patients with high-grade extremity sarcomas, and 132 (84.6%) of 156 patients in this series received chemotherapy. In patients receiving chemotherapy, blood transfusions were associated with increased recurrence (P less than .0001) and decreased survival (P = .0001). The only other significant independent prognostic variable in these patients was the size of the primary tumor. An analysis of all patients, stratified for tumor size, revealed an impact of transfusions on increasing recurrence (P = .007) and decreasing survival (P = .016). An analysis of the subpopulation of patients with large tumors (greater than 150 mL) gave the same results (P = .03 and .015, respectively). It thus appears that the receipt of blood transfusions is associated with increased tumor recurrence and decreased survival in patients with high-grade soft-tissue sarcomas of the extremities.(ABSTRACT TRUNCATED AT 400 WORDS)

Vascular tumors of bone and soft tissue

2013 ◽  
pp. 165-182
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Vascular Tumors ◽  
Tumors Of Bone

Spindle cell tumors of bone and soft tissue in infants and children

2013 ◽  
pp. 23-40
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Infants And Children ◽  
Tumors Of Bone ◽  
Spindle Cell Tumors ◽  
In Infants And Children

Osseous tumors of bone and soft tissue

2013 ◽  
pp. 198-219
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Tumors Of Bone

Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue

2005 ◽  
Vol 36 (9) ◽  
pp. 945-954 ◽  
Author(s):  
Y LAU ◽  
A SABOKBAR ◽  
C GIBBONS ◽  
H GIELE ◽  
N ATHANASOU
Keyword(s):  
Soft Tissue ◽  
Giant Cell ◽  
Giant Cell Tumors ◽  
Molecular Studies ◽  
Tumors Of Bone

Thermographic assessment of skin and soft tissue tumors in cats

2020 ◽  
pp. 1098612X2096104
Author(s):  
Andressa Gianotti Campos Nitrini ◽  
Bruno Cogliati ◽  
Julia Maria Matera
Keyword(s):  
Soft Tissue ◽  
Infrared Thermography ◽  
Normal Skin ◽  
Tumor Grade ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Tumor Type ◽  
Histologic Subtype ◽  
Oncologic Patients ◽  
Neoplastic Lesions

Objectives This study set out to determine the average temperature of skin and soft tissue tumors in cats using infrared thermography and to investigate correlations between thermographic findings and tumor type. Correlations between thermographic findings, histologic subtype and tumor grade were also investigated in cases of feline injection site sarcoma (FISS). Methods Thermographic images of normal skin and skin overlying neoplastic lesions were prospectively obtained. Following thermographic assessment, tumors were resected and submitted to histopathologic and immunohistochemical analysis. Mean temperatures detected in tumoral areas were compared between different tumor types and between FISSs of different histologic subtypes and grades. Results Thermograms obtained from 11 healthy cats and 31 cats presenting with skin and soft tissue tumors (eight benign and 23 malignant tumors, including 21 FISSs) were evaluated in this study. Thermal behavior varied widely in normal skin, as well as in skin overlying neoplastic lesions. Mean temperatures were significantly higher in malignant compared with benign tumors (35.4 ± 1.8ºC and 34.5 ± 1.7ºC respectively; P = 0.01), with a temperature above 34.7ºC being associated with malignancy (sensitivity 76%, specificity 80%; P = 0.01). Temperatures detected in FISS did not differ significantly according to histologic subtype ( P = 0.91) or tumor grade ( P = 0.46), or between primary and recurring tumors ( P = 0.25). Conclusions and relevance Infrared thermography proved to be a sensitive and effective method for detection of temperature differences between malignant and benign skin and soft tissue tumors in cats. Thermographic assessment may contribute to diagnosis and prognostic estimation in feline oncologic patients.

ONCOGENOUS RICKETS: POSSIBLE ELABORATION BY A TUMOR OF A HUMORAL SUBSTANCE INHIBITING TUBULAR REABSORPTION OF PHOSPHATE

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 432-434
Author(s):  
Harold E. Harrison
Keyword(s):  
Vitamin D ◽  
Soft Tissue ◽  
Marked Reduction ◽  
Renal Tubule ◽  
Tubular Reabsorption ◽  
Hypophosphatemic Rickets ◽  
Tumor Excision ◽  
Vitamin D Resistant Rickets ◽  
Tumors Of Bone ◽  
Resistant Rickets

Pollack et al.1 have introduced the intriguing speculation that some rare tumors of mesenchymal origin release a humoral substance which inhibits tubular reabsorption of phosphate and through the resultant profound hypophosphatemia causes vitamin D unresponsive rickets and osteomalacia. There have been sufficient reports of hypophosphatemic vitamin D-resistant rickets and osteomalacia cured by removal of tumors of bone or soft tissue to support the inference that there is a causal relationship between such tumors and the hypophosphatemic rickets. The demonstration of marked reduction of tubular reabsorption of phosphate in such a patient and the dramatic rapid return of tubular reabsorption of phosphate to normal following tumor excision is certainly circumstantial evidence of the secretion by the tumor of an inhibitor of phosphate retrieval by the renal tubule.

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