scholarly journals Ultrasound Ablation: New Possibilities for Treatment of Bone and Soft-Tissue Tumors

2010 ◽  
Vol 17 (2) ◽  
pp. 41-49
Author(s):  
G I Nazarenko ◽  
V Sh Chen ◽  
A N Khitrova
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Secondary Infection ◽  
Local Treatment ◽  
Soft Tissue Tumors ◽  
Treatment Technique ◽  
Tumor Type ◽  
Coagulative Necrosis ◽  
Ultrasound Ablation ◽  
Physical Principles

Focused high intensity ultrasound (HIFU) with sighting influence on tumor enabled to cause its complete coagulative necrosis without damage to intact environmental tissues. The possibilities of ultrasound ablation as the method of local treatment of bone and soft-tissue tumor were considered. Physical principles of method, criteria for patient selection, treatment technique as well as clinical outcomes and their evaluation were presented. Advantages of method are non-invasiveness, less traumatization, less technical complexity and dependence on surgeon skill compared with other sparing operations and methods of ablation. When necessary HIFU may be repeated several times. Effect of HIFU is independent on tumor type. Possible complications (secondary infection in coagulative necrosis zone, peripheral nerves damage, pathological fractures) and measures of their prevention are presented.

Adipocyte-rich CTNNB1-mutated Intramuscular Gardner Fibroma Progressing to Desmoid Fibromatosis

2020 ◽  
pp. 109352662096880
Author(s):  
Andrea Bakker ◽  
Jonathan C Slack ◽  
Mara Caragea ◽  
Kyle C Kurek ◽  
Marie-Anne Bründler
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Soft Tissue Tumors ◽  
Molecular Testing ◽  
Tissue Mass ◽  
Desmoid Fibromatosis ◽  
Benign Soft Tissue Tumor ◽  
First Time ◽  
Generation Sequencing

Gardner fibroma (GF) is a benign soft-tissue tumor that is associated with Gardner syndrome and can progress to, or co-occur with, desmoid fibromatosis (DF). Herein, we report a unique case of an 11-year-old boy who presented with a rapidly growing soft-tissue mass after biopsy of a stable fat-rich lesion present in the calf muscles since infancy, with Magnetic resonance imaging findings suggesting an intramuscular adipocytic tumor. The resection showed GF and DF. DF arising from a preexisting GF (the so-called “GF-DF sequence”) is a well-documented phenomenon. Although immunohistochemistry was negative for nuclear β-catenin expression, a CTTNB1 S45F mutation, which has been associated with aggressive behavior in DF, was identified in both components using a next-generation sequencing-based molecular assay. This is the first time a mutation in CTNNB1 has been identified in GF and the GF–DF sequence, thus expanding our knowledge of the molecular pathogenesis of the GF–DF sequence and highlighting the role of molecular testing in pediatric soft-tissue tumors. The histologic findings of an adipocyte-rich intramuscular GF also are unique, expanding the morphological spectrum of GF and adding GF to the differential diagnosis of intramuscular lesions with an adipocytic component.

Spindle Cell Lipoma of the Foot: A Case Report and Literature Review

1995 ◽  
Vol 16 (4) ◽  
pp. 220-226 ◽  
Author(s):  
Kevin R. Math ◽  
Helene Pavlov ◽  
Edward DiCarlo ◽  
Walther H. O. Bohne
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Imaging Features ◽  
Spindle Cell Lipoma ◽  
Imaging Evaluation ◽  
Presumptive Diagnosis ◽  
Pleomorphic Lipoma ◽  
Atypical Lipoma

Lipomas are among the most commonly encountered soft tissue tumors in clinical practice, though they are rare in the foot. Although a presumptive diagnosis is typically made clinically, those tumors with atypical clinical features may require radiological consultation. Difficulty arises when radiographic features are not typical of lipoma. We present a fatty soft tissue tumor of the foot with nonadipose elements on magnetic resonance imaging evaluation. Differentiation of lipoma variants (e.g., spindle cell lipoma, atypical lipoma, pleomorphic lipoma, lipoblastoma, angiolipoma) from liposarcoma based on imaging features is not possible, necessitating surgical resection for definitive histological diagnosis.

Molecular Cytogenetics and its Applications to Soft Tissue Tumor Analysis

1995 ◽  
Vol 81 (6) ◽  
pp. 395-398 ◽  
Author(s):  
Lucia D'Amato
Keyword(s):  
Soft Tissue ◽  
Genetic Analysis ◽  
Soft Tissue Tumor ◽  
Molecular Cytogenetics ◽  
Soft Tissue Tumors ◽  
Molecular Cytogenetic ◽  
Tissue Tumor ◽  
Cytogenetic Analyses ◽  
Chromosomal Changes ◽  
Sensitive Method

Cytogenetic analyses have demonstrated the association of specific chromosomal changes with particular types of soft tissue tomors. This work describes the molecular cytogenetic approaches to genetic analysis of these tumors. It illustrates how molecular cytogenetics may provide a rapid and sensitive method of diagnosis and can contribute to identify specific genes implied in the aetiology of soft tissue tumors.

Thermographic assessment of skin and soft tissue tumors in cats

2020 ◽  
pp. 1098612X2096104
Author(s):  
Andressa Gianotti Campos Nitrini ◽  
Bruno Cogliati ◽  
Julia Maria Matera
Keyword(s):  
Soft Tissue ◽  
Infrared Thermography ◽  
Normal Skin ◽  
Tumor Grade ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Tumor Type ◽  
Histologic Subtype ◽  
Oncologic Patients ◽  
Neoplastic Lesions

Objectives This study set out to determine the average temperature of skin and soft tissue tumors in cats using infrared thermography and to investigate correlations between thermographic findings and tumor type. Correlations between thermographic findings, histologic subtype and tumor grade were also investigated in cases of feline injection site sarcoma (FISS). Methods Thermographic images of normal skin and skin overlying neoplastic lesions were prospectively obtained. Following thermographic assessment, tumors were resected and submitted to histopathologic and immunohistochemical analysis. Mean temperatures detected in tumoral areas were compared between different tumor types and between FISSs of different histologic subtypes and grades. Results Thermograms obtained from 11 healthy cats and 31 cats presenting with skin and soft tissue tumors (eight benign and 23 malignant tumors, including 21 FISSs) were evaluated in this study. Thermal behavior varied widely in normal skin, as well as in skin overlying neoplastic lesions. Mean temperatures were significantly higher in malignant compared with benign tumors (35.4 ± 1.8ºC and 34.5 ± 1.7ºC respectively; P = 0.01), with a temperature above 34.7ºC being associated with malignancy (sensitivity 76%, specificity 80%; P = 0.01). Temperatures detected in FISS did not differ significantly according to histologic subtype ( P = 0.91) or tumor grade ( P = 0.46), or between primary and recurring tumors ( P = 0.25). Conclusions and relevance Infrared thermography proved to be a sensitive and effective method for detection of temperature differences between malignant and benign skin and soft tissue tumors in cats. Thermographic assessment may contribute to diagnosis and prognostic estimation in feline oncologic patients.

Prevalence of Symptomatic Venous Thromboembolism in Patients with Malignant Bone and Soft Tissue Tumors Undergo Surgery without Chemoprophylaxis

2021 ◽  
Vol 104 (5) ◽  
pp. 728-732
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Significant Risk ◽  
Soft Tissue Tumors ◽  
Tumor Patients ◽  
Tissue Tumor ◽  
Picture Archiving And Communication

Background: The prevalence and risk factors of venous thromboembolism (VTE) in malignant bone and soft tissue tumor patients that undergo surgery is reported in many studies. However, there is lack of studies on the patients without chemoprophylaxis. Objective: To evaluate the prevalence and risk factors for VTE after surgery in malignant bone and soft tissue tumor patients without chemoprophylaxis Materials and Methods: A retrospective medical chart review identified 260 cases of malignant bone and soft tissue tumor operated between 2008 and 2017. Official diagnostic reports were reviewed from the Picture Archiving and Communication System (PACs). The incidence of VTE and its risk factors were assessed using Chi-square test, t-test, and binary logistic regression. Results: The overall prevalence of symptomatic VTE was 0.8% (2/260 patients), all of which had PE. No fatal VTE was detected. Asymptomatic pulmonary embolism (PE) was identified in two patients (0.8%) Mean follow up interval of the available data was 9.5 (3 to 36) months. No significant risk factor was found. Conclusion: The authors found that patients with malignant bone and soft tissue tumors that underwent surgery without chemoprophylaxis in the authors’ center had lower prevalence of VTE when compared to most previous studies whose patient received chemoprophylaxis. Keywords: Venous thromboembolism, Sarcoma, Cancer, Deep vein thrombosis, Pulmonary embolism, Thromboprophylaxis, Chemoprophylaxis

Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma

2020 ◽  
Vol 232 (06) ◽  
pp. 285-288
Author(s):  
Susanne Deeg ◽  
Lucas Wessel ◽  
Richard Martel ◽  
Stefan Porubsky ◽  
Daniel Svoboda
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Tumor ◽  
Soft Tissue Tumors ◽  
Diagnostic Specificity ◽  
Total Removal ◽  
Subcutaneous Tumor ◽  
Microsurgical Technique ◽  
The Right

AbstractAt the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a biopsy at the age of 5 months malignancy could be excluded. Finally at the age of 16 months the tumor which had meanwhile grown to a monstrous size (5 cm of diameter) could be entirely removed by microsurgical technique maintaining the integrity of all intrinsic structures. The diagnosis of myxoid lipoblastoma was confirmed. According to literature, Lipoblastomas often present as connatal rapid growing soft tissue tumors and are benign. Total removal is essential for avoiding a local recurrence.

Surgical Management and Minimally Invasive Approaches for the Treatment of Metastatic Sarcoma

2013 ◽  
pp. 457-464
Author(s):  
Peter Hohenberger ◽  
Bernd Kasper ◽  
Kamran Ahrar
Keyword(s):  
Soft Tissue ◽  
Minimally Invasive ◽  
Early Stage ◽  
Tumor Biology ◽  
Local Treatment ◽  
Soft Tissue Sarcomas ◽  
Metastatic Tumor ◽  
Soft Tissue Tumors ◽  
Tumor Spread ◽  
Systemic Treatments

Soft tissue sarcomas describe a very heterogeneous group of soft tissue tumors mainly arising in the lower extremities. If diagnosed at an early stage and a complete resection of the primary tumor is achieved, the patients' prognosis is excellent. However, metastatic tumor spread is common with only limited treatment possibilities. Despite an improved insight into tumor biology of sarcomas, no notable improvement has been gained in the last 20 years regarding prognosis of patients. Metastatic lung disease has long been the preserve of systemic treatments, local treatments being considered in a purely palliative intention. Several studies have objectified benefit to the local treatment of metastases, especially in an oligometastatic state. The development of techniques for stereotactic radiotherapy on the one hand and the refusal or contraindication for surgery on the other hand inaugurated studies in this direction. Besides surgery and radiotherapy, other local modalities have been investigated in the last few years such as thermal therapy (radiofrequency and laser ablation) or combined modalities (isolated limb perfusion and deep-wave hyperthermia plus chemotherapy) to help patients with metastatic soft tissue sarcoma. Minimally invasive, image-guided therapies such as thermal ablation should be considered particularly in patients who are not suitable surgical candidates or may have exhausted all other viable surgical options. Some of these techniques will be reviewed in this article, and their value for the patients will be evaluated in the light of indication from tumor biology and technical feasibility. These highly selected and specific procedures should only be performed after decision making in an interdisciplinary sarcoma-board.

scholarly journals SECONDARY INFECTION IN CANCER PATIENTS OF THE MUSCULOSKELETAL SYSTEM

2021 ◽  
Vol 06 (01) ◽  
pp. 39-43
Author(s):  
Ahliman Amiraslanov Ahliman Amiraslanov ◽  
Elnur Ibragimov Elnur Ibragimov ◽  
Sevinj Abdiyeva Sevinj Abdiyeva ◽  
Samira Qaraisayeva Samira Qaraisayeva
Keyword(s):  
Soft Tissue ◽  
Cancer Patients ◽  
Secondary Infection ◽  
Soft Tissue Tumors ◽  
Infectious Complications ◽  
Pathological Process ◽  
Wound Complications ◽  
Malignant Neoplasms ◽  
Treatment And Prevention ◽  
Secondary Infections

Infectious diseases complications remain one of the main problems of surgery. Infections are one of the causes of canser patients morbidity and mortality, along with tumor diseases. The frequency of postoperative wound complications varies between 3-34% depending on the type of surgery [5]. Cancer patients are more susceptible to the systematic immunosuppresive state, caused by malignant neoplasms and directly by antitumor therapy. It is obvious that the anticancer problem of treatment and prevention of secondary infections in these conditions becomes even more urgent than before. Objective: To analise infections complications (IC) caused by microorganisms depending on antitumor treatment in cancer patients. Materials and methods: The study included 41 (100%) cancer patients with infectious complications during antitumor treatment in the Azerbaijan Medical University (AMU) Cancer clinic for skin and soft tissue neoplasms. Most often, the pathological process was lokalized in the lower extremities in 19 (46%) patients; in the upper extremities in 14 (34,1%) patients: in the trunk in 8 (19,5%) patients. Of these 12 patients (29,2%) patients received treatment for posteopertive complicattions, 10 (24%) patients received treatment for complications – related to chemotherapy and 19 (46%) patients received treatmentrelated to radiation therapy. There were 28 (68%) men and 13 woman (36,5%) patients. The age of the patients ranged from 34 to 82 years among the studied patients with soft tissue tumors 24 (58%), skin tumors 17 (41,4%) patients .

scholarly journals Soft Tissue Tumor

2021 ◽  
Vol 1 (12) ◽  
pp. 831-844
Author(s):  
Anindhita Pangestika ◽  
Lalu Wisnu R Danu N
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Malignant Tumors ◽  
Fibrous Tissue ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Environmental Carcinogens ◽  
Benign Soft Tissue Tumors ◽  
Malignant Lesions ◽  
Chronic Lymphedema

Soft tissue tumors are a heterogeneous group of benign and malignant lesions that develop from a variety of nonepithelial, extraskeletal elements, including adipose tissue, smooth and skeletal muscle, tendons, cartilage, fibrous tissue, blood vessels, and lymphatic structures. The writing of this article includes various sources originating from scientific journals and government guidelines and related agencies. Source searches were carried out on online portals for journal publications such as Med Scape Google Scholar (scholar.google.com) and the National Centre for Biotechnology Information/NCBI (ncbi.nlm.nih.gov), with the keyword “Sensoric Nerve Trauma”. Soft tissue tumors (STT) can be benign or malignant, and benign soft tissue tumors are more common than malignant tumors with a ratio of 100: 1. In a study of 93 cases of soft tissue tumors, it was found that the incidence of benign tumors was 75.2% and malignant tumors were 24.8%. Soft tissue tumors are associated with genetic conditions, radiation, chronic lymphedema, environmental carcinogens, and infections.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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