scholarly journals Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine

2009 ◽  
Vol 58 (9) ◽  
pp. 1397-1405 ◽  
Author(s):  
Govind Ragupathi ◽  
Payal Damani ◽  
Geeta Srivastava ◽  
Om Srivastava ◽  
Steven J. Sucheck ◽  
...  
Keyword(s):  
Sialyl Lewisa

scholarly journals Expression of Sialyl Lewisa as a new prognostic factor for patients with advanced colorectal carcinoma

Cancer ◽  
1995 ◽  
Vol 75 (8) ◽  
pp. 2051-2056 ◽  
Author(s):  
Takamori Nakayama ◽  
Masahiko Watanabe ◽  
Takao Katsumata ◽  
Tatsuo Teramoto ◽  
Masaki Kitajima
Keyword(s):  
Prognostic Factor ◽  
Colorectal Carcinoma ◽  
Advanced Colorectal Carcinoma ◽  
Sialyl Lewisa

scholarly journals Targeting Selectins Mediated Biological Activities With Multivalent Probes

2021 ◽  
Vol 9 ◽  
Author(s):  
Deepak Ganesh ◽  
Prashant Jain ◽  
Chethan Devanur Shanthamurthy ◽  
Suraj Toraskar ◽  
Raghavendra Kikkeri
Keyword(s):  
Tumor Metastasis ◽  
Inflammatory Diseases ◽  
Biological Activities ◽  
Type I ◽  
Blood Capillaries ◽  
Activated Platelets ◽  
Selectin Ligands ◽  
Different Types ◽  
Selectin Binding ◽  
Sialyl Lewisa

Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in the blood capillaries, and recruit them to inflammatory sites. Hence, they are potential markers for the early detection and inhibition of inflammatory diseases, thrombosis, cardiovascular disorders, and tumor metastasis. Fucosylated and sialylated glycans, such as sialyl Lewisx, its isoform sialyl Lewisa, and heparan sulfate, are primary selectin ligands. Functionalization of these selectin-binding ligands on multivalent probes, such as nanoparticles, liposomes, and polymers, not only inhibits selectin-mediated biological activity but is also involved in direct imaging of the inflammation site. This review briefly summarizes the selectin-mediated various diseases such as thrombosis, cancer and recent progress in the different types of multivalent probes used to target selectins.

scholarly journals Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: The importance of surface sialyl Lewisa antigen

1996 ◽  
Vol 69 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Takashi Kishimoto ◽  
Hiroshi Ishikura ◽  
Chisa Kimura ◽  
Toshiyuki Takahashi ◽  
Hiroyuki Kato ◽  
...  
Keyword(s):  
Pancreas Adenocarcinoma ◽  
Sialyl Lewisa

Endothelial-selectin ligands sialyl Lewisx and sialyl Lewisa are differentiation antigens immunogenic in human melanoma

Cancer ◽  
1997 ◽  
Vol 79 (9) ◽  
pp. 1686-1697 ◽  
Author(s):  
Mepur H. Ravindranath ◽  
Amir A. Amiri ◽  
Philip M. Bauer ◽  
Mark C. Kelley ◽  
Richard Essner ◽  
...  
Keyword(s):  
Human Melanoma ◽  
Sialyl Lewisx ◽  
Differentiation Antigens ◽  
Selectin Ligands ◽  
Sialyl Lewisa

Substrate specificity of fucosyl transferase III: An efficient synthesis of sialyl Lewisx-, sialyl Lewisa-derivatives and mimetics thereof

2000 ◽  
Vol 78 (6) ◽  
pp. 892-904 ◽  
Author(s):  
Beat Ernst ◽  
Bea Wagner ◽  
Gabi Baisch ◽  
Andreas Katopodis ◽  
Tammo Winkler ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Enzymatic Synthesis ◽  
Reaction Rates ◽  
Efficient Synthesis ◽  
Natural Substrate ◽  
Sialyl Lewisx ◽  
Sialyl Lewis ◽  
Sialyl Lewisa

Fucosyl transferase III (FucT III) has previously been characterized as the most general enzyme of the FucT family, as judged from its ability to catalyze the transfer of fucose to both Galβ(1-3)GlcNAc and Galβ(1-4)GlcNAc. In order to explore the synthetic potential of FucT III for the enzymatic synthesis of sialyl Lewisx and sialyl Lewisa derivatives, its substrate specificity has been probed using a number of natural substrate mimetics. A remarkable range of acceptor substrates was found when N-acetyl glucosamine was replaced by D-glucal, (R,R)-1,2-cyclohexanediol and (R,R)-butan-2,3-diol. Although the reaction rates were low compared to the reaction with the natural substrates, they proved to be sufficient for the synthesis of preparative amounts.Key words: fucosyl transferase III, sialyl Lewisa, sialyl Lewisx, carbohydrate mimetics.

Western blot analysis of glycoproteins bearing lewisa and sialyl-lewisa antigens in human colorectal mucosa

1993 ◽  
Vol 54 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Tsukasa Takabayashi ◽  
Masahiko Watanabe ◽  
Yoichi Sakurai ◽  
Kokichi Sugano ◽  
Susumu Kodaira ◽  
...  
Keyword(s):  
Western Blot ◽  
Blot Analysis ◽  
Western Blot Analysis ◽  
Colorectal Mucosa ◽  
Sialyl Lewisa

scholarly journals Changes of the expression of Lewis blood group antigens in glycoproteins of renal cancer tissues.

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Małgorzata Borzym-Kluczyk ◽  
Iwona Radziejewska
Keyword(s):  
Sialic Acid ◽  
Blood Group ◽  
Tumor Development ◽  
Renal Tissue ◽  
Cancer Tissue ◽  
Blood Group Antigens ◽  
Lewis Blood Group ◽  
Significant Difference ◽  
Cancer Tissues ◽  
Sialyl Lewisa

Sialic acid and sialyl Lewisa/x are found on N- and O-glycans of many human malignant cells. Carbohydrate antigens can be used as tumor markers, and an increase of their levels in cancer cells is associated with tumor progression. The aim of this study was to assess the level of some Lewis blood group antigens on glycoproteins in tumor (cancer tissue), intermediate zone (adjacent to tumor tissue), and normal renal cortex/medulla (uninvolved by tumor). The study was performed on tissues taken from 30 patients. Relative amounts of sugar structures of proteins with molecular masses above 30 kDa were determined by ELISA-like test with biotinylated lectins: MAA (Maackia amurensis), SNA (Sambucus nigra), and monoclonal antibodies anti-sialyl Lewisa/x.∙ Higher expression of all examined structures was revealed in cancer tissues. Significant increases were observed for sialic acid linked α 2-3 in cancer tissues when compared to healthy ones and also among intermediate and healthy tissues. The sialic acid linked α 2-6 and sialyl Lewisx structures were significantly increased in cancerous cells when compared to normal and intermediate renal tissue. In case of sialyl Lewisa antigen, a significant difference was discovered between normal and intermediate tissue. Our results confirm that the examined Lewis antigens can be involved in tumor development. Their increase in cancer tissues can suggest their specific role in the process.

scholarly journals Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity

2011 ◽  
Vol 17 (5) ◽  
pp. 1024-1032 ◽  
Author(s):  
Ritsuko Sawada ◽  
Shu-Man Sun ◽  
Xiaohong Wu ◽  
Feng Hong ◽  
Govind Ragupathi ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Antitumor Activity ◽  
Human Monoclonal Antibodies ◽  
Sialyl Lewisa

Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewisa and sialyl-Lewisx antigens in colorectal adenocarcinoma

2002 ◽  
Vol 40 (5) ◽  
pp. 440-449 ◽  
Author(s):  
S E Baldus ◽  
S P Monig ◽  
F-G Hanisch ◽  
T K Zirbes ◽  
U Flucke ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Prognostic Value ◽  
Colorectal Adenocarcinoma ◽  
Sialyl Lewisx ◽  
Sialyl Lewisa
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