Invited Discussion on: A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution – Clinical and Histological Study

2020 ◽  
Vol 44 (5) ◽  
pp. 1613-1614
Author(s):  
Dennis C. Hammond
Keyword(s):  
Ascorbic Acid ◽  
Histological Study ◽  
Ascorbyl Palmitate ◽  
New Treatment

scholarly journals A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study

2020 ◽  
Vol 44 (5) ◽  
pp. 1604-1612
Author(s):  
Antonio Scarano ◽  
Andrea Sbarbati ◽  
Roberto Amore ◽  
Eugenio Luigi Iorio ◽  
Giuseppe Ferraro ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Adipose Tissue ◽  
Histological Study ◽  
Ascorbyl Palmitate ◽  
The Body ◽  
Full Description ◽  
Level Of Evidence ◽  
Direct Infiltration ◽  
New Treatment ◽  
Pharmacologically Active

Abstract Background Localized adiposity (AL) is the accumulation of subcutaneous adipose tissue, placed in definite anatomic areas, building up an alteration of the body silhouette. The aim of the present clinical and histological study is to assess the effectiveness of an injectable solution containing sodium salt of ascorbic acid 0.24% and surfactant agent at 0.020% ascorbyl-palmitate (SAP) for treating local adiposity. Methods Eighty healthy female adult patients were selected, suffering from local adiposity in the abdominal region. The patients underwent a cycle of 6 sessions, with biweekly treatments, without the addition of any active ingredient. Direct infiltration of pharmacologically active SAP solutions into the adipose tissue with a long needle, very similar to the needles used for spinal anesthesia, was performed. This procedure is quick and painless (does not require any anesthesia) with moderate infiltration speed. Results All the patients treated showed good results with good satisfaction of the circumferential reductions. Before treatment: Waist (cm) 78.8 ± 10.6 and hip 93.6 ± 9.0 with WHR 0.84 ± 0.07. After treatment: Waist (cm) 70.8 ± 9.6 and hip 92.6 ± 8.0 with WHR 0.76 ± 0.06. Indeed, signs of adipocyte apoptosis were observed in subcutaneous skin after injection of SAP. Conclusion The results showed in the present study suggest that the SAP utilized induces apoptosis of adipocytes and could be of use as a safe and effective method with which to eliminate subcutaneous abdominal fat. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Chemical Synthesis of Ascorbyl Palmitate in [BMIM]BF4

2011 ◽  
Vol 236-238 ◽  
pp. 1962-1965 ◽  
Author(s):  
Jun Min Ji
Keyword(s):  
Ascorbic Acid ◽  
Ionic Liquid ◽  
Sulfuric Acid ◽  
Chemical Synthesis ◽  
Palmitic Acid ◽  
Ascorbyl Palmitate ◽  
Highly Efficient ◽  
Concentrated Sulfuric Acid

Scorbyl palmitate is a safty and highly efficient lipophilic antioxidant.It is produced by a novel ionic liquid method: L-ascorbic acid was esterified with palmitic acid to synthesize ascorbyl palmitate,using concentrated sulfuric acid as chemical catalyst in 1-Butyl-3-methy limidazolium terafluoroborate ([BMIM]BF4).The yield of ascorbyl palmitate reached 69.6±1%.

THE APPLICATION OF NATURAL AND SYNTHETIC ANTIOXIDANTS TO INCREASE THE OXIDATION RESISTANCE OF LINSeED OIL

2020 ◽  
Vol 13 (4(50)) ◽  
pp. 41-51
Author(s):  
I. P. Edimecheva ◽  
A. A. Sosnovskaya ◽  
O. I. Shadyro
Keyword(s):  
Ascorbic Acid ◽  
Kinetic Data ◽  
Room Temperature ◽  
Linseed Oil ◽  
Ascorbyl Palmitate ◽  
Natural Antioxidants ◽  
Oxidation Products ◽  
Free Access ◽  
Synthetic Antioxidants ◽  
Acid Esters

The effectiveness of several synthetic and natural antioxidants (AO) in inhibiting the oxidation of linseed oil has been studied. Under the conditions of accelerated oxidation at 100 °С, the values of the induction period of oxidation and stabilization factors of linseed oil in the presence of additives of known phenolic AOs, tocopherols, fat-soluble ascorbic acid esters and compositions based on them were determined. The data obtained indicate that ascorbic acid esters effectively inhibit the oxidation of linseed oil. The stabilizing effect of ascorbyl palmitate (AP) increases with an elevation in the content of α-linolenic acid in the oil and a decrease in the oxidative stability of the oil. One AP provided better stabilization efficiency than some known compositions based on it. Kinetic data on the accumulation of oxidation products in linseed oil with AP additives during the storage at room temperature and with free access of the air were obtained, demonstrating high inhibiting activity of AP under these conditions, which provides a possibility to increase the shelf life of the stabilized oil up to 18 months or more.

scholarly journals Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3227 ◽  
Author(s):  
Carolina Tufiño ◽  
Claudia Bernal ◽  
Carminna Ottone ◽  
Oscar Romero ◽  
Andrés Illanes ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Palmitic Acid ◽  
Immobilized Lipase ◽  
Antioxidant Properties ◽  
Reaction Medium ◽  
Pseudomonas Stutzeri ◽  
Ascorbyl Palmitate ◽  
Downstream Processing ◽  
High Reactivity ◽  
Molar Ratio

Ascorbyl palmitate is a fatty acid ester endowed with antioxidant properties, used as a food additive and cosmetic ingredient, which is presently produced by chemical synthesis. Ascorbyl palmitate was synthesized from ascorbic acid and palmitic acid with a Pseudomonas stutzeri lipase immobilized on octyl silica, and also with the commercial immobilized lipase Novozym 435. The latter was selected for optimizing the reaction conditions because of its high reactivity and stability in the solvent 2-methyl-2-butanol used as reaction medium. The reaction of the synthesis was studied considering temperature and molar ratio of substrates as variables and synthesis yield as response parameter. The highest yield in the synthesis of ascorbyl palmitate was 81%, obtained at 55 °C and an ascorbic acid to palmitic acid molar ratio of 1:8, both variables having a strong effect on yield. The synthesized ascorbyl palmitate was purified to 94.4%, with a purification yield of 84.2%. The use of generally recognized as safe (GRAS) certified solvents with a polarity suitable for the solubilization of the compounds made the process a viable alternative for the synthesis and downstream processing of ascorbyl palmitate.

Ascorbyl palmitate as a source of tissue ascorbic acid

1986 ◽  
Vol 22 (1) ◽  
pp. 37-40 ◽  
Author(s):  
R.E. Hughes ◽  
Eleri Jones
Keyword(s):  
Ascorbic Acid ◽  
Ascorbyl Palmitate
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