Clinical Implication of Cancer Adhesion in Papillary Thyroid Carcinoma: Clinicopathologic Characteristics and Prognosis Analyzed with Degree of Extrathyroidal Extension

Background. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear.Methods. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC.BRAFmutation was tested with pyrosequencing.Results. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto’s thyroiditis than classic PTCs (93% versus 36%, resp.,P< 0.001) and showed significantly lower rate ofBRAFmutation when compared to classic PTCs (65% versus 84%, resp.,P= 0.007). In classic PTC, the frequency ofBRAFmutations was negatively correlated with coexisting Hashimoto’s thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto’s thyroiditis, there were no significant differences in clinicopathologic characteristics or theBRAFmutational rate between the two groups.Conclusions. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto’s thyroiditis.

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Association between hTERT Polymorphisms and Female Papillary Thyroid Carcinoma

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892814666190919145453 ◽

2019 ◽

Vol 14 (3) ◽

pp. 268-279

Author(s):

Ying Liu ◽

Zhi Li ◽

Xinyue Tang ◽

Min Li ◽

Feng Shi

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Genome Wide Association Study ◽

Papillary Thyroid ◽

Clinicopathologic Characteristics ◽

Female Population ◽

Genome Wide ◽

Increased Risk ◽

Significant Difference ◽

Thyroid Cancer Risk

Background: A previous genome-wide association study showed that hTERT rs10069690 and rs2736100 polymorphisms were associated with thyroid cancer risk. Objective: This study further investigated the association between increased risk and clinicopathologic characteristics for Papillary Thyroid Carcinoma (PTC) and hTERT polymorphisms rs10069690 or rs2736100 in a Chinese female population. Methods: The hTERT genotypes of 276 PTC patients and 345 healthy subjects were determined with regard to SNPs rs10069690 and rs2736100. The association between these SNPs and the risk of PTC and clinicopathologic characteristics was investigated by logistic regression. Results: We found a significant difference between PTC and rs10069690 (Odds Ratio (OR) = 1.515; P = 0.005), but not between PTC and rs2736100. When the analysis was limited to females, rs10069690 and rs2736100 were both associated with increased risk for PTC in female individuals (OR = 1.647, P = 0.007; OR = 1.339, P = 0.041, respectively). Further haplotype analysis revealed a stimulative effect of haplotypes TC and CA of TERT rs10069690-rs2736100, which increased risk for PTC in female individuals (OR = 1.579, P = 0.014; OR = 0.726, P = 0.025, respectively). Furthermore, the heterozygote A/C of rs2736100 showed significant difference for age (OR = 0.514, P = 0.047). Conclusion: Our finding suggests that hTERT polymorphisms rs10069690 and rs2736100 are associated with increased risk for PTC in Chinese female population and rs2736100 may be related to age. Consistent with US20170360914 and US20170232075, they are expected to be a potential molecular target for anti-cancer therapy.

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Enemy Beyond the Wall: Clinicopathological Features of Intrathyroidal Papillary Thyroid Carcinoma (T1-T3a) That Metastasize to Lymph Nodes Without Extrathyroidal Extension

Cancer Investigation ◽

10.1080/07357907.2021.1897833 ◽

2021 ◽

pp. 1-8

Author(s):

Abbas Ali Tam ◽

Nurcan Ince ◽

Husniye Baser ◽

Ayşegul Aksoy Altinboga ◽

Mehmet Kilic ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Lymph Nodes ◽

Extrathyroidal Extension ◽

Clinicopathological Features ◽

Papillary Thyroid

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Risk of recurrence in patients with papillary thyroid carcinoma and minimal extrathyroidal extension not treated with radioiodine

Journal of Endocrinological Investigation ◽

10.1007/s40618-018-0969-y ◽

2018 ◽

Vol 42 (6) ◽

pp. 687-692 ◽

Cited By ~ 5

Author(s):

P. W. Rosario ◽

G. Mourão ◽

M. R. Calsolari

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Extrathyroidal Extension ◽

Papillary Thyroid ◽

Risk Of Recurrence ◽

Minimal Extrathyroidal Extension

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Papillary Thyroid Carcinoma Arising in Children and Adolescent Hashimoto’s Thyroiditis: Ultrasonographic and Pathologic Findings

International Journal of Endocrinology ◽

10.1155/2016/2397690 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Sun Hye Jeong ◽

Hyun Sook Hong ◽

Eun Hye Lee ◽

Jeong Ja Kwak

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Gland ◽

Thyroid Carcinoma ◽

Lymph Node Metastases ◽

Hashimoto’S Thyroiditis ◽

Extrathyroidal Extension ◽

Hashimoto's Thyroiditis ◽

Papillary Thyroid ◽

Node Metastases

Objectives. We compared the ultrasonography and pathology features of papillary thyroid carcinoma (PTC) in pediatric and adolescents with Hashimoto’s thyroiditis (HT) with those of non-HT patients.Materials and Methods. Eleven patients who were surgically confirmed to have pediatric or adolescent PTC from 2006 to 2014 were included in this study. We retrospectively analyzed the preoperative ultrasonography and pathology features of PTC arising in HT and non-HT patients.Results. On ultrasonography, thyroid gland was lobulated and enlarged, with many scattered microcalcifications in four of five HT patients. Four of six non-HT patients had suspicious masses with calcifications. The diffuse sclerosing variant of PTC (DSVPTC) was found in three of five HT patients, but none in non-HT patients. Macroscopic or microscopic extrathyroidal extension was evident in all of the HT patients and four of the non-HT patients. Neck lymph node metastases were in all HT patients and five of non-HT patients.Conclusions. Three of five PTCs in pediatric and adolescent HT patients were DSVPTC, whereas all PTCs of the non-HT patients were classic type. On ultrasonography, thyroid gland was diffusely enlarged with scattered microcalcifications in four of five HT patients. All five HT cases had aggressive disease, including extrathyroidal extension and cervical lymph node metastases.

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