Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines

2012 ◽  
Vol 69 (6) ◽  
pp. 1601-1615 ◽  
Author(s):  
Annett Mueller ◽  
Erika Bachmann ◽  
Monika Linnig ◽  
Katrin Khillimberger ◽  
Carl Christoph Schimanski ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Gastrointestinal Cancer ◽  
Cancer Cell Lines ◽  
Wild Type ◽  
Pi3k Inhibition

scholarly journals Downregulated mRNA expression of ASPP and the hypermethylation of the 5′-untranslated region in cancer cell lines retaining wild-type p53

FEBS Letters ◽  
2005 ◽  
Vol 579 (7) ◽  
pp. 1587-1590 ◽  
Author(s):  
Ze-Jun Liu ◽  
Xin Lu ◽  
Yun Zhang ◽  
Shan Zhong ◽  
Shou-Zhi Gu ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Untranslated Region ◽  
Cancer Cell Lines ◽  
Wild Type ◽  
Wild Type P53

Modulation of β-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53

The Prostate ◽  
2007 ◽  
Vol 67 (16) ◽  
pp. 1751-1760 ◽  
Author(s):  
Alexandra Prowald ◽  
Marcus V. Cronauer ◽  
Christoph von Klot ◽  
Tyark Eilers ◽  
Ludwig Rinnab ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Mutant P53 ◽  
Wild Type ◽  
Prostate Cancer Cell Lines

scholarly journals Inhibition of MUS81 By siRNA Reverses Resistance to Cisplatin in Human Ovarian Cancer Cell Lines

2021 ◽  
Author(s):  
Emma C. Bourton ◽  
Sheba Adam-Zahir ◽  
Piers N. Plowman ◽  
Hussein Nahidh Al-Ali ◽  
Helen A. Foster ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Resistant Cell ◽  
Wild Type ◽  
Ovarian Cancer Cell Lines ◽  
Sirna Knockdown

Abstract Bacground: Drugs that induce DNA interstrand crosslinks form the mainstay of anticancer treatments for different cancers. These drugs are used to treat ovarian cancer which is the most prevalent gynaecological cancer. Five-year survival rates are approximately 40% and the development of drug resistant disease is an important factor in treatment failure. Methods: In this study a comprehensive evaluation of the expression and function of the site-specific endonuclease MUS81 was conducted. Using quantitative real time PCR analysis and imaging flow cytometry we determined the mRNA and protein expression of MUS81 in three ovarian cancer cell lines and two immortalised human fibroblast cell lines which had been made resistant to cisplatin by chronic exposure. siRNA knockdown of MUS81 was employed to determine the effect on overall cell survival which was assessed using clonogenic assays. Results: In the five cisplatin-resistant cell lines we observed increased MUS81 mRNA expression. In addition MUS81 protein expression in the form of discrete nuclear foci in cells was observed in all cell lines following cisplatin exposure, there being significantly more foci in cisplatin resistant cell lines. siRNA knockdown of MUS81 significantly reduced both mRNA and protein levels in two cell lines (SK-OV-3 and MRC5-SV1 – wild-type and resistant) and critically re-sensitised cisplatin resistant cells to wild-type level, determined by clonogenic assay.Conclusion: MUS81 is central to the development of cisplatin resistance in ovarian cancer cell lines. Inhibition of MUS81 restored drug sensitivity to the cells. MUS81 may be a useful therapeutic target to overcome drug resistance in ovarian and other cancers.

Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines

2015 ◽  
Vol 33 (2) ◽  
pp. 310-320 ◽  
Author(s):  
Laura Lattanzio ◽  
Federica Tonissi ◽  
Martino Monteverde ◽  
Daniela Vivenza ◽  
Elvio Russi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Treatment Effect ◽  
Cancer Cell Lines ◽  
Wild Type

scholarly journals Telomerase Reverse Transcriptase Promoter Mutations in Human Hepatobiliary, Pancreatic and Gastrointestinal Cancer Cell Lines

In Vivo ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 94-102
Author(s):  
MASAHIRO HIRATA ◽  
KOJI FUJITA ◽  
SHINTARO FUJIHARA ◽  
TAKAAKI MIZUO ◽  
RYOTA NAKABAYASHI ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastrointestinal Cancer ◽  
Cancer Cell Lines ◽  
Telomerase Reverse Transcriptase ◽  
Promoter Mutations
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