Intertwining roles of circadian and metabolic regulation of the innate immune response

2022 ◽  
Author(s):  
Shannon L. Cox ◽  
James R. O’Siorain ◽  
Lauren E. Fagan ◽  
Annie M. Curtis ◽  
Richard G. Carroll
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Metabolic Regulation ◽  
Innate Immune

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial

Macrophage-derived extracellular vesicles mediate a long-lasting innate immune response against hepatitis C virus

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
C Cai ◽  
B Koch ◽  
S Akhras ◽  
E Hildt ◽  
S Zeuzem ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Extracellular Vesicles ◽  
Innate Immune Response ◽  
Innate Immune

IKK2 hepatocyte specific deletion accelerates the liver regeneration and enhances the innate immune response in mice

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
Y Malato ◽  
N Beraza ◽  
LE Sander ◽  
L Sander ◽  
M Al-Masaoudi ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Regeneration ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Specific Deletion
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