Faculty Opinions recommendation of Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response.

2002 ◽  
Author(s):  
Giorgio Berton
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Pulmonary Inflammation ◽  
Innate Immune ◽  
Src Family Kinase ◽  
Constitutive Activation

scholarly journals Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection

2010 ◽  
Vol 293 (6) ◽  
pp. 968-981 ◽  
Author(s):  
Sean Gill ◽  
Thomas N. Wight ◽  
Charles W. Frevert
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Pulmonary Inflammation ◽  
Lung Infection ◽  
Innate Immune

scholarly journals Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response

2002 ◽  
Vol 196 (5) ◽  
pp. 589-604 ◽  
Author(s):  
Matthias Ernst ◽  
Melissa Inglese ◽  
Glen M. Scholz ◽  
Kenneth W. Harder ◽  
Fiona J. Clay ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Tyrosine Kinases ◽  
Physiological Role ◽  
Lung Parenchyma ◽  
Innate Immune ◽  
Lung Pathology ◽  
Loss Of Function ◽  
Constitutive Activation

To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated HckF/F “knock-in” mice which carry a targeted tyrosine (Y) to phenylalanine (F) substitution of the COOH-terminal, negative regulatory Y499-residue in the Hck protein. Unlike their Hck−/− “loss-of-function” counterparts, HckF/F “gain-of-function” mice spontaneously acquired a lung pathology characterized by extensive eosinophilic and mononuclear cell infiltration within the lung parenchyma, alveolar airspaces, and around blood vessels, as well as marked epithelial mucus metaplasia in conducting airways. Lungs from HckF/F mice showed areas of mild emphysema and pulmonary fibrosis, which together with inflammation resulted in altered lung function and respiratory distress in aging mice. When challenged transnasally with lipopolysaccharide (LPS), HckF/F mice displayed an exaggerated pulmonary innate immune response, characterized by excessive release of matrix metalloproteinases and tumor necrosis factor (TNF)α. Similarly, HckF/F mice were highly sensitive to endotoxemia after systemic administration of LPS, and macrophages and neutrophils derived from HckF/F mice exhibited enhanced effector functions in vitro (e.g., nitric oxide and TNFα production, chemotaxis, and degranulation). Based on the demonstrated functional association of Hck with leukocyte integrins, we propose that constitutive activation of Hck may mimic adhesion-dependent priming of leukocytes. Thus, our observations collectively suggest an enhanced innate immune response in HckF/F mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial

Macrophage-derived extracellular vesicles mediate a long-lasting innate immune response against hepatitis C virus

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
C Cai ◽  
B Koch ◽  
S Akhras ◽  
E Hildt ◽  
S Zeuzem ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Extracellular Vesicles ◽  
Innate Immune Response ◽  
Innate Immune

IKK2 hepatocyte specific deletion accelerates the liver regeneration and enhances the innate immune response in mice

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
Y Malato ◽  
N Beraza ◽  
LE Sander ◽  
L Sander ◽  
M Al-Masaoudi ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Regeneration ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Specific Deletion
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