Single nucleotide polymorphisms (SNPs) in genes related to innate immune response against Salmonella in nursery pigs

The aim of this study is to describe the prevalence of single single-nucleotide polymorphisms (SNPs) as well as their combinations in genes encoding proteins involved in the immune response in children with bacterial meningitis. The prospective study group consisted of 39 children with bacterial meningitis and 49 family members surveyed between 2012 and 2016. Eleven SNPs in seven genes involved in immune response were analysed. The mean number of minor frequency alleles (MAF) of studied SNPs was lowest in the control group and highest in patients with pneumococcal meningitis. We found that carrying ≥6 MAF of studied SNPs was associated with an increased risk of pneumococcal meningitis. The prevalence of risky variants was noted to be higher in patients with pneumococcal meningitis as compared to the control group. In conclusion, genetic factors are a relevant factor in determining the susceptibility to bacterial meningitis. A statistically significant cumulative effect of mutated variants on increasing the risk of bacterial meningitis was detected. Combining all three SNPs in MBL2 improves the prediction of susceptibility to pneumococcal meningitis. Analysis of risky alleles can help indicate people prone to the disease who are ‘gene-immunocompromised’.

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Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14,TLR4, Ce, andFce R1 alpha

International Journal of Immunogenetics ◽

10.1111/j.1744-313x.2005.00522.x ◽

2005 ◽

Vol 32 (5) ◽

pp. 277-283 ◽

Cited By ~ 16

Author(s):

L. Vychodilova-Krenkova ◽

J. Matiasovic ◽

P. Horin

Keyword(s):

Immune Response ◽

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Immune Response Genes

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Single nucleotide polymorphisms in collagenous lectins and other innate immune genes in pigs with common infectious diseases

Veterinary Immunology and Immunopathology ◽

10.1016/j.vetimm.2011.02.011 ◽

2011 ◽

Vol 142 (1-2) ◽

pp. 1-13 ◽

Cited By ~ 18

Author(s):

N.D. Keirstead ◽

M.A. Hayes ◽

G.E. Vandervoort ◽

A.S. Brooks ◽

E.J. Squires ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Infectious Diseases ◽

Innate Immune ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Immune Genes ◽

Innate Immune Genes

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Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes

The Open Orthopaedics Journal ◽

10.2174/1874325001509010367 ◽

2015 ◽

Vol 9 (1) ◽

pp. 367-371

Author(s):

Maarten W.G.A. Bronkhorst ◽

Peter Patka ◽

Esther M.M. Van Lieshout

Keyword(s):

Single Nucleotide Polymorphisms ◽

Public Health Problem ◽

Injured Patient ◽

Severe Trauma ◽

Infectious Complications ◽

Innate Immune ◽

Major Public Health Problem ◽

Trauma Patients ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma patient with multiple infectious complications caused by multiple micro-organisms leading to prolonged hospital stay with numerous treatments. This patient had multiple single nucleotide polymorphisms (SNPs) in the MBL2, MASP2, FCN2 and TLR2 genes, most likely contributing to increased susceptibility and severity of infectious disease.

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