Protective Effect of Furocoumarins Against 254-nm Ultraviolet in Staphylococcus aureus

2005 ◽  
Vol 52 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Humberto M. Barreto ◽  
José P. Siqueira-Junior
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect

scholarly journals Interleukin-10 (IL-10) Produced by Mutant Toxic Shock Syndrome Toxin 1 Vaccine-Induced Memory T Cells Downregulates IL-17 Production and Abrogates the Protective Effect against Staphylococcus aureus Infection

2019 ◽  
Vol 87 (10) ◽  
Author(s):  
Kouji Narita ◽  
Dong-Liang Hu ◽  
Krisana Asano ◽  
Akio Nakane
Keyword(s):  
Staphylococcus Aureus ◽  
T Cells ◽  
Infectious Diseases ◽  
Protective Effect ◽  
Toxic Shock Syndrome ◽  
Long Term Memory ◽  
Toxic Shock ◽  
Content Type ◽  
Memory Phase ◽  
Toxic Shock Syndrome Toxin

ABSTRACT Development of long-term memory is crucial for vaccine-induced adaptive immunity against infectious diseases such as Staphylococcus aureus infection. Toxic shock syndrome toxin 1 (TSST-1), one of the superantigens produced by S. aureus, is a possible vaccine candidate against infectious diseases caused by this pathogen. We previously reported that vaccination with less toxic mutant TSST-1 (mTSST-1) induced T helper 17 (Th17) cells and elicited interleukin-17A (IL-17A)-mediated protection against S. aureus infection 1 week after vaccination. In the present study, we investigated the host immune response induced by mTSST-1 vaccination in the memory phase, 12 weeks after the final vaccination. The protective effect and IL-17A production after vaccination with mTSST-1 were eliminated because of IL-10 production. In the presence of IL-10-neutralizing monoclonal antibody (mAb), IL-17A production was restored in culture supernatants of CD4+ T cells and macrophages sorted from the spleens of vaccinated mice. Vaccinated mice treated with anti-IL-10 mAb were protected against systemic S. aureus infection in the memory phase. From these results, it was suggested that IL-10 produced in the memory phase suppresses the IL-17A-dependent vaccine effect through downregulation of IL-17A production.

scholarly journals THE IN VIVO INTERACTION BETWEEN STAPHYLOCOCCUS BACTERIOPHAGE AND STAPHYLOCOCCUS AUREUS

1963 ◽  
Vol 118 (1) ◽  
pp. 13-26 ◽  
Author(s):  
P. F. Bartell ◽  
I. S. Thind ◽  
T. Orr ◽  
W. S. Blakemore
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Protective Role ◽  
Protection Time ◽  
Determining Factors ◽  
Specific Bacteriophage ◽  
And Staphylococcus Aureus

Staphylococcus bacteriophage 81 is capable of in vivo interaction with Staphylococcus aureus, Type 80/81. This is immediately made evident by increased levels of bacteriophage and concomitant survival of 81 per cent infected mice. The reaction is dependent upon the use of active, type-specific bacteriophage. The maximal protective effect is observed at a bacteriophage to bacteria ratio of 1:2 and decreased quantities of bacteriophage result in decreased protection. Time and sequence of administration are also determining factors. It is evident that bacteriophage administered intravenously is capable of interaction with the infecting bacterial cell at the site of infection. In vivo produced bacteriophage is apparently eliminated or otherwise rendered nondetectable fairly rapidly, occurring within a period of 5 to 10 days. However, it appears that host defense mechanisms are stimulated in the process and actively play a protective role against subsequent challenge inocula administered up to 3 weeks later.

scholarly journals Protective effect of acidic mannan fraction of bakers' yeast against Staphylococcus aureus infection in mice.

1985 ◽  
Vol 8 (11) ◽  
pp. 942-947 ◽  
Author(s):  
YOSHIO OKAWA ◽  
YASUSHI OKURA ◽  
KAZUHIKO HASHIMOTO ◽  
KO SUZUKI ◽  
SHIGEO SUZUKI ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
Aureus Infection

scholarly journals Protective effect of nimesulide on the external ear damage induced by staphylococcus aureus inoculation in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 577
Author(s):  
Ertugrul Erhan ◽  
Ismail Salcan ◽  
Muhammet Dilber ◽  
Sumeyye Akyuz ◽  
Bulent Dabanlioglu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
External Ear

Mechanism of the temperature protective effect of salts on Staphylococcus aureus

1980 ◽  
Vol 26 (4) ◽  
pp. 511-517 ◽  
Author(s):  
A. Hurst ◽  
A. Hughes ◽  
R. Pontefract
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
Cell Walls ◽  
Maximum Temperature ◽  
Irregular Cell ◽  
Capsular Material

In the previous paper we reported that the maximum temperature for growth of Staphylococcus aureus was about 2 °C higher in media supplemented with NaCl. We now show that MgCl2 was the most effective protectant at 0.4 M. NaCl and KCl were as effective as MgCl2 when tested at 1 M. NH4Cl was less effective at all concentrations and LiCl was not protective. Sucrose and glucose (1 M) gave about half the biomass of 1 M NaCl. Glycerol, Na2SO4, NaNO2, NaNO3, and CH3COONa were not protective. Protection is probably due to the nonpenetrating solute (sucrose) or the nonpenetrating Cl− anion. Mg2+ had an effect additional to that attributable to Cl− because MgSO4 and to a slight extent (CH3COO)2Mg were protective. The morphology of the cells grown at 45 °C in 1 M NaCl was abnormal: septation became irregular, cell walls were thickened, and the cells occurred in irregularly sized clumps surrounded by capsular material.

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