Diphenyl pyrimidine exhibits protective effect on Staphylococcus aureus pneumonia in rat model by targeting NLRP3 expression

2021 ◽  
pp. 105168
Author(s):  
Wei Duan ◽  
Feizhang Qin ◽  
Dean Wu ◽  
Yunhong Dai
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
Rat Model ◽  
Staphylococcus Aureus Pneumonia ◽  
Nlrp3 Expression

Protective effect of CpG-DNA against mastitis induced by Staphylococcus aureus infection in a rat model

2007 ◽  
Vol 7 (4) ◽  
pp. 435-443 ◽  
Author(s):  
Yu-Min Zhu ◽  
Jin-Feng Miao ◽  
Hong-Ji Fan ◽  
Si-Xiang Zou ◽  
Wei-Hua Chen
Keyword(s):  
Staphylococcus Aureus ◽  
Protective Effect ◽  
Rat Model ◽  
Cpg Dna ◽  
Aureus Infection

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

Association between a rapid diagnostic test to detect methicillin-resistant Staphylococcus Aureus pneumonia and decreased vancomycin use in a medical intensive care unit over a 30-month period

2021 ◽  
pp. 1-3
Author(s):  
Chiagozie I. Pickens ◽  
Chao Qi ◽  
Michael Postelnick ◽  
Joseph Paonessa ◽  
Helen K. Donnelly ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Medical Intensive Care Unit ◽  
Pcr Assay ◽  
Days Of Therapy ◽  
Medical Intensive Care ◽  
Staphylococcus Aureus Pneumonia ◽  
Few Data ◽  
Rule Out

Abstract Vancomycin overuse is common, yet few data are available regarding how to improve stewardship of this antibiotic. We identify an association between use of a PCR assay to rule out MRSA pneumonia and a significant, sustained decrease in average vancomycin days of therapy over a 30-month period.

Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model

2019 ◽  
Vol 21 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Yasushi Shibue ◽  
Soichiro Kimura ◽  
Chiaki Kajiwara ◽  
Yoichiro Iwakura ◽  
Keizo Yamaguchi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Interleukin 17 ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Pneumonia

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

2016 ◽  
Vol 16 (12) ◽  
pp. 1364-1376 ◽  
Author(s):  
Stefano Aliberti ◽  
Luis F Reyes ◽  
Paola Faverio ◽  
Giovanni Sotgiu ◽  
Simone Dore ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Observational Cohort ◽  
Global Initiative ◽  
Staphylococcus Aureus Pneumonia

Appropriate Pharmacokinetic Index for Outcome in Staphylococcus aureus Pneumonia

CHEST Journal ◽  
2007 ◽  
Vol 132 (3) ◽  
pp. 1101-1102 ◽  
Author(s):  
Brian A. Potoski ◽  
David L. Paterson
Keyword(s):  
Staphylococcus Aureus ◽  
Staphylococcus Aureus Pneumonia

scholarly journals Protective Effect of Alpha-Melanocyte-Stimulating Hormone (α-MSH) on the Recovery of Ischemia/Reperfusion (I/R)-Induced Retinal Damage in A Rat Model

2013 ◽  
Vol 50 (3) ◽  
pp. 558-570 ◽  
Author(s):  
Balazs Varga ◽  
Rudolf Gesztelyi ◽  
Mariann Bombicz ◽  
David Haines ◽  
Adrienn Monika Szabo ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Model ◽  
Ischemia Reperfusion ◽  
Retinal Damage ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone
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