Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla

Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity. Their richness in secondary metabolites is related to their unique and diverse metabolic apparatus, such as Non-Ribosomal Peptide Synthetases (NRPSs). One important class of peptides produced by the non-ribosomal pathway is anabaenopeptins. These cyclic hexapeptides demonstrated inhibitory activity towards phosphatases and proteases, which could be related to their toxicity and adaptiveness against zooplankters and crustaceans. Thus, this review aims to identify key features related to anabaenopeptins, including the diversity of their structure, occurrence, the biosynthetic steps for their production, ecological roles, and biotechnological applications.

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Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris : The anti-cancer bisanthraquinone skyrin

Journal of Biotechnology ◽

10.1016/j.jbiotec.2017.06.410 ◽

2017 ◽

Vol 257 ◽

pp. 233-239 ◽

Cited By ~ 16

Author(s):

Linda Jahn ◽

Thomas Schafhauser ◽

Daniel Wibberg ◽

Christian Rückert ◽

Anika Winkler ◽

...

Keyword(s):

Secondary Metabolites ◽

Fungal Endophyte ◽

Anti Cancer

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Secondary Metabolites of the Endophytic Fungi Penicillium polonicum and Their Monoamine Oxidase Inhibitory Activity

Chemistry of Natural Compounds ◽

10.1007/s10600-018-2540-7 ◽

2018 ◽

Vol 54 (5) ◽

pp. 1018-1019 ◽

Cited By ~ 2

Author(s):

Muammer Abdelwahed Elsunni ◽

Zhong-Duo Yang

Keyword(s):

Secondary Metabolites ◽

Monoamine Oxidase ◽

Endophytic Fungi ◽

Inhibitory Activity

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Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation

Phytochemistry ◽

10.1016/j.phytochem.2014.10.008 ◽

2014 ◽

Vol 108 ◽

pp. 189-195 ◽

Cited By ~ 7

Author(s):

Sachiko Sugimoto ◽

Amira Samir Wanas ◽

Tsutomu Mizuta ◽

Katsuyoshi Matsunami ◽

Mohamed Salah Kamel ◽

...

Keyword(s):

Secondary Metabolites ◽

Advanced Glycation End Products ◽

Inhibitory Activity ◽

Structure Elucidation ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

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Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds

Molecules ◽

10.3390/molecules25122895 ◽

2020 ◽

Vol 25 (12) ◽

pp. 2895

Author(s):

Hitomi Sasaki ◽

Yuzuru Kubohara ◽

Hirotaka Ishigaki ◽

Katsunori Takahashi ◽

Hiromi Eguchi ◽

...

Keyword(s):

Cell Proliferation ◽

Secondary Metabolites ◽

Natural Product ◽

Inhibitory Activity ◽

Osteoclast Differentiation ◽

Fruiting Bodies ◽

Slime Molds ◽

Cellular Slime ◽

Cellular Slime Molds ◽

Product Chemistry

We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.

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