Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla

2019 ◽  
Vol 76 (7) ◽  
pp. 904-908 ◽  
Author(s):  
Zhong-Duo Yang ◽  
Zhi-Jie Li ◽  
Jun-Wen Zhao ◽  
Jian-Hui Sun ◽  
Li-Jun Yang ◽  
...  
2018 ◽  
Vol 33 (1) ◽  
pp. 108-112 ◽  
Author(s):  
Xiao-Wei Chen ◽  
Zhong-Duo Yang ◽  
Xiao-Fei Li ◽  
Jian-Hui Sun ◽  
Li-Jun Yang ◽  
...  

2017 ◽  
Vol 32 (8) ◽  
pp. 880-884 ◽  
Author(s):  
Xiao-Wei Chen ◽  
Zhong-Duo Yang ◽  
Jian-hui Sun ◽  
Tong-tong Song ◽  
Bao-ying Zhu ◽  
...  

Fitoterapia ◽  
2016 ◽  
Vol 113 ◽  
pp. 158-163 ◽  
Author(s):  
Bo Wei ◽  
Zhong-Duo Yang ◽  
Xiao-wei Chen ◽  
Shuang-Yan Zhou ◽  
Hai-Tao Yu ◽  
...  

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 522
Author(s):  
Patrick Romano Monteiro ◽  
Samuel Cavalcante do Amaral ◽  
Andrei Santos Siqueira ◽  
Luciana Pereira Xavier ◽  
Agenor Valadares Santos

Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity. Their richness in secondary metabolites is related to their unique and diverse metabolic apparatus, such as Non-Ribosomal Peptide Synthetases (NRPSs). One important class of peptides produced by the non-ribosomal pathway is anabaenopeptins. These cyclic hexapeptides demonstrated inhibitory activity towards phosphatases and proteases, which could be related to their toxicity and adaptiveness against zooplankters and crustaceans. Thus, this review aims to identify key features related to anabaenopeptins, including the diversity of their structure, occurrence, the biosynthetic steps for their production, ecological roles, and biotechnological applications.


2017 ◽  
Vol 257 ◽  
pp. 233-239 ◽  
Author(s):  
Linda Jahn ◽  
Thomas Schafhauser ◽  
Daniel Wibberg ◽  
Christian Rückert ◽  
Anika Winkler ◽  
...  

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2895
Author(s):  
Hitomi Sasaki ◽  
Yuzuru Kubohara ◽  
Hirotaka Ishigaki ◽  
Katsunori Takahashi ◽  
Hiromi Eguchi ◽  
...  

We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.


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