Comparison of continuous vs. pulsed focused ultrasound in treated muscle tissue as evaluated by magnetic resonance imaging, histological analysis, and microarray analysis

2008 ◽  
Vol 18 (5) ◽  
pp. 993-1004 ◽  
Author(s):  
Walter Hundt ◽  
Esther L. Yuh ◽  
Silke Steinbach ◽  
Mark D. Bednarski ◽  
Samira Guccione
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Microarray Analysis ◽  
Muscle Tissue ◽  
Focused Ultrasound ◽  
Histological Analysis ◽  
Resonance Imaging ◽  
Pulsed Focused Ultrasound

Technical and radiographic considerations for magnetic resonance imaging–guided focused ultrasound capsulotomy

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Benjamin Davidson ◽  
Karim Mithani ◽  
Yuexi Huang ◽  
Ryan M. Jones ◽  
Maged Goubran ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Neurosurgical Procedures ◽  
Lesion Volume ◽  
Angle Of Incidence ◽  
Resonance Imaging ◽  
Radiographic Findings ◽  
Compulsive Disorder ◽  
Skull Thickness

OBJECTIVEMagnetic resonance imaging–guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently been demonstrated to be safe and effective in treating obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). Preliminary evidence has suggested that bilateral MRgFUS capsulotomy can present increased difficulties in reaching lesional temperatures as compared to unilateral thalamotomy. The authors of this article aimed to study the parameters associated with successful MRgFUS capsulotomy lesioning and to present longitudinal radiographic findings following MRgFUS capsulotomy.METHODSUsing data from 22 attempted MRgFUS capsulotomy treatments, the authors investigated the relationship between various sonication parameters and the maximal temperature achieved at the intracranial target. Lesion volume and morphology were analyzed longitudinally using structural and diffusion tensor imaging. A retreatment procedure was attempted in one patient, and their postoperative imaging is presented.RESULTSSkull density ratio (SDR), skull thickness, and angle of incidence were significantly correlated with the maximal temperature achieved. MRgFUS capsulotomy lesions appeared similar to those following MRgFUS thalamotomy, with three concentric zones observed on MRI. Lesion volumes regressed substantially over time following MRgFUS. Fractional anisotropy analysis revealed a disruption in white matter integrity, followed by a gradual return to near-baseline levels concurrent with lesion regression. In the patient who underwent retreatment, successful bilateral lesioning was achieved, and there were no adverse clinical or radiographic events.CONCLUSIONSWith the current iteration of MRgFUS technology, skull-related parameters such as SDR, skull thickness, and angle of incidence should be considered when selecting patients suitable for MRgFUS capsulotomy. Lesions appear to follow morphological patterns similar to what is seen following MRgFUS thalamotomy. Retreatment appears to be safe, although additional cases will be necessary to further evaluate the associated safety profile.

MAGNETIC RESONANCE IMAGING-GUIDED FOCUSED ULTRASOUND FOR THERMAL ABLATION IN THE BRAIN

Neurosurgery ◽  
2007 ◽  
Vol 60 (4) ◽  
pp. 593-600 ◽  
Author(s):  
Zvi R. Cohen ◽  
Jacob Zaubermann ◽  
Sagi Harnof ◽  
Yael Mardor ◽  
Dvora Nass ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
Resonance Imaging ◽  
The Brain
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