Feasibility of low-dose CT with spectral shaping and third-generation iterative reconstruction in evaluating interstitial lung diseases associated with connective tissue disease: an intra-individual comparison study

2019 ◽  
Vol 29 (9) ◽  
pp. 4529-4537
Author(s):  
Xiaoli Xu ◽  
Xin Sui ◽  
Lan Song ◽  
Yao Huang ◽  
Yingqian Ge ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Iterative Reconstruction ◽  
Lung Diseases ◽  
Low Dose ◽  
Interstitial Lung Diseases ◽  
Third Generation ◽  
Comparison Study ◽  
Low Dose Ct ◽  
Individual Comparison

Automated detection and classification of interstitial lung diseases from low-dose CT images

2004 ◽  
Author(s):  
Bin Zheng ◽  
Joseph K. Leader ◽  
Carl R. Fuhrman ◽  
Frank C. Sciurba ◽  
David Gur
Keyword(s):  
Lung Diseases ◽  
Low Dose ◽  
Ct Images ◽  
Interstitial Lung Diseases ◽  
Automated Detection ◽  
Low Dose Ct

scholarly journals Comparison of Characteristics of Connective Tissue Disease-Associated Interstitial Lung Diseases, Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Diseases, and Idiopathic Pulmonary Fibrosis in Chinese Han Population: A Retrospective Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Lin Pan ◽  
Yuan Liu ◽  
Rongfei Sun ◽  
Mingyu Fan ◽  
Guixiu Shi
Keyword(s):  
Interstitial Lung Disease ◽  
Idiopathic Pulmonary Fibrosis ◽  
Connective Tissue ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Connective Tissue Disease ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Western China ◽  
Undifferentiated Connective Tissue Disease

Our study compared the prevalence and characteristics of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD), or idiopathic pulmonary fibrosis (IPF) between January 2009 and December 2012 in West China Hospital, western China. Patients who met the criteria for ILD were included and were assigned to CTD-ILD, UCTD-ILD, or IPF group when they met the criteria for CTD, UCTD, or IPF, respectively. Clinical characteristics, laboratory tests, and high-resolution CT images were analyzed and compared among three groups. 203 patients were included, and all were Han nationality. CTD-ILD was identified in 31%, UCTD-ILD in 32%, and IPF in 37%. Gender and age differed among groups. Pulmonary symptoms were more common in IPF, while extrapulmonary symptoms were more common in CTD-ILD and UCTD-ILD group. Patients with CTD-ILD had more abnormal antibody tests than those of UCTD-ILD and IPF. Little significance was seen in HRCT images among three groups. A systematic evaluation of symptoms and serologic tests in patients with ILD can identify CTD-ILD, UCTD-ILD, and IPF.

scholarly journals Computer-aided detection of early interstitial lung diseases using low-dose CT images

2011 ◽  
Vol 56 (4) ◽  
pp. 1139-1153 ◽  
Author(s):  
Sang Cheol Park ◽  
Jun Tan ◽  
Xingwei Wang ◽  
Dror Lederman ◽  
Joseph K Leader ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Low Dose ◽  
Ct Images ◽  
Interstitial Lung Diseases ◽  
Computer Aided Detection ◽  
Low Dose Ct ◽  
Computer Aided

scholarly journals Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)

2020 ◽  
pp. annrheumdis-2020-217230 ◽  
Author(s):  
Paolo Spagnolo ◽  
Oliver Distler ◽  
Christopher J Ryerson ◽  
Argyris Tzouvelekis ◽  
Joyce S Lee ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lung Diseases ◽  
Kinase Inhibitor ◽  
Target Population ◽  
Interstitial Lung Diseases ◽  
Proof Of Concept ◽  
Phase Ii Studies ◽  
Early Proof ◽  
Genetic Mechanisms

Interstitial lung diseases (ILDs), which can arise from a broad spectrum of distinct aetiologies, can manifest as a pulmonary complication of an underlying autoimmune and connective tissue disease (CTD-ILD), such as rheumatoid arthritis-ILD and systemic sclerosis (SSc-ILD). Patients with clinically distinct ILDs, whether CTD-related or not, can exhibit a pattern of common clinical disease behaviour (declining lung function, worsening respiratory symptoms and higher mortality), attributable to progressive fibrosis in the lungs. In recent years, the tyrosine kinase inhibitor nintedanib has demonstrated efficacy and safety in idiopathic pulmonary fibrosis (IPF), SSc-ILD and a broad range of other fibrosing ILDs with a progressive phenotype, including those associated with CTDs. Data from phase II studies also suggest that pirfenidone, which has a different—yet largely unknown—mechanism of action, may also have activity in other fibrosing ILDs with a progressive phenotype, in addition to its known efficacy in IPF. Collectively, these studies add weight to the hypothesis that, irrespective of the original clinical diagnosis of ILD, a progressive fibrosing phenotype may arise from common, underlying pathophysiological mechanisms of fibrosis involving pathways associated with the targets of nintedanib and, potentially, pirfenidone. However, despite the early proof of concept provided by these clinical studies, very little is known about the mechanistic commonalities and differences between ILDs with a progressive phenotype. In this review, we explore the biological and genetic mechanisms that drive fibrosis, and identify the missing evidence needed to provide the rationale for further studies that use the progressive phenotype as a target population.

scholarly journals Reconciling Healthcare Professional and Patient Perspectives in the Development of Disease Activity and Response Criteria in Connective Tissue Disease–related Interstitial Lung Diseases

2014 ◽  
Vol 41 (4) ◽  
pp. 792-798 ◽  
Author(s):  
Lesley Ann Saketkoo ◽  
Shikha Mittoo ◽  
Sid Frankel ◽  
Daphne LeSage ◽  
Catherine Sarver ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Outcome Measures ◽  
Working Group ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Patient Perspectives ◽  
High Morbidity ◽  
Core Set

Interstitial lung diseases (ILD), including those related to connective tissue disease (CTD), and idiopathic pulmonary fibrosis (IPF) carry high morbidity and mortality. Great efforts are under way to develop and investigate meaningful treatments in the context of clinical trials. However, efforts have been challenged by a lack of validated outcome measures and by inconsistent use of measures in clinical trials. Lack of consensus has fragmented effective use of strategies in CTD-ILD and IPF, with a history of resultant difficulties in obtaining agency approval of treatment interventions. Until recently, the patient perspective to determine domains and outcome measures in CTD-ILD and IPF had never been applied. Efforts described here demonstrate unequivocally the value and influence of patient involvement on core set development. Regarding CTD-ILD, this is the first OMERACT working group to directly address a manifestation/comorbidity of a rheumatic disease (ILD) as well as a disease not considered rheumatic (IPF). The OMERACT 11 proceedings of the CTD-ILD Working Group describe the forward and lateral process to include both the medical and patient perspectives in the urgently needed identification of a core set of preliminary domains and outcome measures in CTD-ILD and IPF.

Sign in / Sign up

Export Citation Format

Share Document