Crim1C140S mutant mice reveal the importance of cysteine 140 in the internal region 1 of CRIM1 for its physiological functions

2019 ◽  
Vol 30 (11-12) ◽  
pp. 329-338
Author(s):  
Tatsuya Furuichi ◽  
Manami Tsukamoto ◽  
Masaki Saito ◽  
Yuriko Sato ◽  
Nobuyasu Oiji ◽  
...  
Keyword(s):  
Mutant Mice ◽  
Physiological Functions ◽  
Internal Region

scholarly journals Glycosphingolipid functions: insights from engineered mouse models

2003 ◽  
Vol 358 (1433) ◽  
pp. 879-883 ◽  
Author(s):  
Richard L. Proia
Keyword(s):  
Mouse Models ◽  
Structural Complexity ◽  
Mutant Mice ◽  
Stages Of Development ◽  
Physiological Functions ◽  
New Information ◽  
Different Tissues

Glycosphingolipids are remarkable for their structural complexity and their distinctive patterns that mark different tissues and stages of development. The physiological functions of glycosphingolipids are likely to be profound and are only beginning to emerge. Much of this new information is due to the study of mutant mice lacking specific sets of glycosphingolipids, the topic of this review.

Physiological functions of protein kinase B/Akt

2004 ◽  
Vol 32 (2) ◽  
pp. 350-354 ◽  
Author(s):  
Z.-Z. Yang ◽  
O. Tschopp ◽  
A. Baudry ◽  
B. Dümmler ◽  
D. Hynx ◽  
...  
Keyword(s):  
Cell Culture ◽  
Protein Kinase ◽  
Mouse Models ◽  
Knockout Mouse ◽  
Genetic Manipulation ◽  
Protein Kinase B ◽  
Mutant Mice ◽  
Physiological Functions ◽  
The Past ◽  
Elegant Method

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

Author response for "Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery"

2018 ◽  
Author(s):  
Alicia S. Wilson ◽  
Hsei Di Law ◽  
Christiane B. Knobbe‐Thomsen ◽  
Conor J. Kearney ◽  
Jane Oliaro ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Mutant Mice ◽  
Author Response
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