scholarly journals EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review

2019 ◽  
Vol 34 (11) ◽  
pp. 1989-1993
Author(s):  
Yanhua Zhou ◽  
Yanlin Zhang ◽  
Haiying Zhao ◽  
Xuan Cui ◽  
Yongqiu Wei ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Case Reports ◽  
Relevant Literature ◽  
Case Presentation ◽  
Barr Virus ◽  
Tract Involvement ◽  
Inflammatory Bowel ◽  
Epstein Barr ◽  
Histopathological Evidence ◽  
Immunocompetent Patients

Abstract Introduction Epstein-Barr virus (EBV)–associated lymphoproliferative diseases (LPD) with digestive tract involvement in immunocompetent patients is rather rare. Since the symptoms of EBV-associated LPD involving the gastrointestinal tract in immunocompetent patients are similar to those of inflammatory bowel disease (IBD), most patients are initially misdiagnosed. Case presentation In this paper, we present two cases of EBV-associated T cell LPD involving the colon in immunocompetent patients and review the relevant literature. Conclusion EBV serological testing may help in detecting this disease, and our findings suggest that histopathological evidence of EBV, such as the Epstein-Barr encoding region, is very important to establish the diagnosis.

Are Viruses and Parasites Linked to Celiac Disease? A Question that Still has no Definite Answer

2019 ◽  
Vol 20 (14) ◽  
pp. 1181-1193 ◽  
Author(s):  
Aref Shariati ◽  
Hamid R. Aslani ◽  
Mohammad R.H. Shayesteh ◽  
Ali Taghipour ◽  
Ahmad Nasser ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Multiple Roles ◽  
Barr Virus ◽  
The People ◽  
Intestinal Infections ◽  
Inflammatory Bowel ◽  
Epstein Barr ◽  
Irritable Bowel ◽  
Related Proteins

Celiac Disease (CD) is a complex autoimmune enteropathy of the small intestine that commonly occurs in genetically predisposed individuals due to intake of gluten and related proteins. Gluten consumption, duration of breast-feeding, various infections, especially frequent intestinal infections, vaccinations and use of antibiotics can be linked to CD. It is predicted that it affects 1% of the global population and its incidence rate is increasing. Most of the people with the HLA-DQ2 or HLADQ8 are at a higher risk of developing this disease. The link between infections and autoimmune diseases has been very much considered in recent years. In several studies, we explained that pathogenic and non-pathogenic microorganisms might have multiple roles in initiation, exacerbation, and development of Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). In various studies, the relationship between infections caused by viruses, such as Epstein-Barr Virus (EBV), Rotavirus, Hepatitis C (HCV), Hepatitis B virus (HBV), Cytomegalovirus (CMV), and Influenza virus, and parasites including Giardia spp. and Toxoplasma gondii with CD has been raised. However, increasing evidence proposes that some of these microorganisms, especially helminths, can also have protective and even therapeutic roles in the CD process. Therefore, in order to determine the role of microorganisms in the process of this disease, we attempted to summarize the evidence suggesting the role of viral and parasitic agents in pathogenesis of CD.

Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients

Blood ◽  
2004 ◽  
Vol 104 (1) ◽  
pp. 243-249 ◽  
Author(s):  
Wing-Yan Au ◽  
Annie Pang ◽  
Carolyn Choy ◽  
Chor-Sang Chim ◽  
Yok-Lam Kwong
Keyword(s):  
Multivariate Analysis ◽  
Natural Killer ◽  
Epstein Barr Virus ◽  
Nk Cell ◽  
Disease Stage ◽  
Tumor Biomarker ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Immunocompetent Patients

Abstract In Epstein-Barr-virus (EBV)–positive lymphomas in immunocompetent patients, release of EBV DNA from tumor cells into the plasma might be useful for disease monitoring and prognostication. To test this hypothesis, we quantified serially plasma EBV DNA by quantitative polymerase chain reaction in 39 cases of EBV-positive (natural killer [NK] cell, n = 23; T cell, n = 8; B cell, n = 4; Hodgkin, n = 4) lymphomas. As control, EBV DNA was undetectable in 34 cases of EBV-negative lymphomas at diagnosis and during chemotherapy. In all cases of EBV-positive lymphomas, EBV DNA was detectable (105-1010 copies/mL) at diagnosis. It paralleled the clinical course, with EBV DNA becoming undetectable at remission and remaining elevated in refractory disease. On multivariate analysis, high-presentation EBV DNA (> 7.3 × 107 copies/mL) was significantly associated with an inferior overall survival (OS). Subgroup analysis of NK cell lymphomas, the largest cohort in this study, showed that presentation EBV DNA was correlated with disease stage and lactate dehydrogenase. On multivariate analysis, high-presentation EBV DNA (> 6.1 × 107 copies/mL) was significantly associated with an inferior disease-free survival. During treatment, patients with EBV DNA that showed further increases or failed to become undetectable had significantly inferior OS. In EBV-positive lymphomas, plasma EBV DNA is valuable as a tumor biomarker and for prognostication.

scholarly journals P669 Inflammatory bowel disease and Epstein-Barr virus: analysis of our experience

2014 ◽  
Vol 8 ◽  
pp. S350
Author(s):  
Á. Araujo Míguez ◽  
C. Trigo Salado ◽  
J.L. Márquez Galán ◽  
M.D. De la Cruz Ramírez ◽  
J.M. Herrera Justiniano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Inflammatory Bowel ◽  
Epstein Barr

Epstein-Barr virus–positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine

2002 ◽  
Vol 122 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Gerald A. Dayharsh ◽  
Edward V. Loftus ◽  
William J. Sandborn ◽  
William J. Tremaine ◽  
Alan R. Zinsmeister ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Inflammatory Bowel ◽  
Epstein Barr

Impact of Epstein-Barr virus serological status on clinical outcomes in adult patients with inflammatory bowel disease

2018 ◽  
Vol 48 (7) ◽  
pp. 723-730 ◽  
Author(s):  
Ruth de Francisco ◽  
Andrés Castaño-García ◽  
Susana Martínez-González ◽  
Isabel Pérez-Martínez ◽  
Ana J. González-Huerta ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Outcomes ◽  
Bowel Disease ◽  
Epstein Barr Virus ◽  
Adult Patients ◽  
Barr Virus ◽  
Serological Status ◽  
Inflammatory Bowel ◽  
Epstein Barr

Characteristics of Lymphoma in Patients with Inflammatory Bowel Disease: A Systematic Review

2020 ◽  
Author(s):  
Marie Muller ◽  
Julien Broséus ◽  
Pierre Feugier ◽  
Catherine Thieblemont ◽  
Laurent Beaugerie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malt Lymphoma ◽  
Survival Data ◽  
Clinical Characteristics ◽  
De Novo ◽  
B Cell Lymphoma ◽  
Epidemiological Data ◽  
Barr Virus ◽  
Inflammatory Bowel ◽  
Epstein Barr

Abstract Background Lymphoma is a dreaded complication of inflammatory bowel diseases [IBD]. Knowledge about lymphoma in patients with IBD is limited to epidemiological data and the description of risk factors. We performed a systematic review to describe the clinical characteristics and prognosis of lymphoma in patients with IBD. Methods Electronic databases were searched up to June 1, 2020. All published clinical characteristics of lymphoma occurring in patients with IBD were collected. Results Eleven studies were included. A total of 589 lymphomas were described in patients with IBD. As seen in de novo lymphoma, non-Hodgkin’s lymphoma [NHL] was the most common histological subtype [83.9%]. Diffuse large B-cell lymphoma [DLBCL] and follicular lymphoma were the most well-represented NHL in patients with IBD [30% and 13% respectively]. Two main differences were observed in comparison with de novo lymphoma: primary intestinal lymphoma [PIL] represented a large proportion of lymphoma in patients with IBD [22–75%] whereas mucosa-associated lymphoid tissue [MALT] lymphoma was under-represented. Epstein–Barr virus [EBV]-positive status was observed in a large proportion of tumours [44–75%]. Survival data of lymphoma in patients with IBD were similar to those of de novo lymphoma. Discussion This systematic review first highlights that PIL [especially DLBCL subtype] is significantly more frequent in patients with IBD and represents the most common entity. Conversely, MALT lymphoma is extremely rare in the IBD population. However, the overall quality of the evidence is low. Further studies are required to better define lymphoma characteristics in patients with IBD.

scholarly journals Acute Acalculous Cholecystitis Associated with Epstein–Barr Infection: A Case Report and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Konstantinos Ntelis ◽  
Dimosthenis Mazarakis ◽  
Apostolos Sapountzis ◽  
Dimitra Zissi ◽  
Sophia Sparangi ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Rare Complication ◽  
Relevant Literature ◽  
Young Patients ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Barr Virus ◽  
Ebv Infection ◽  
Rare Manifestation ◽  
Epstein Barr

The most common cause of acute cholecystitis (ACC) is cholelithiasis. Acute acalculous cholecystitis (AAC) is well documented in the literature related with critical illness, but viral causes such as cytomegalovirus (CMV) and Epstein–Barr virus (EBV) have also been reported. We present a rare manifestation of EBV infection, reporting a case of a 15-year-old female suffering from acute acalulous cholecystitis, and we review the relevant literature. Clinicians should be aware of this rare complication of EBV infection and properly exclude it in young patients with cholecystitis.

Su1114 Intestinal Epstein-Barr Virus Is Associated With Mucosal Lymphoproliferation and Subsequent Intestinal Surgery in Inflammatory Bowel Disease Patients

2014 ◽  
Vol 146 (5) ◽  
pp. S-378-S-379
Author(s):  
Loes Nissen ◽  
Dirk J. De Jong ◽  
Iris D. Nagtegaal ◽  
Wietske Kievit ◽  
Lauranne A. Derikx ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Epstein Barr Virus ◽  
Intestinal Surgery ◽  
Barr Virus ◽  
Inflammatory Bowel ◽  
Epstein Barr
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