Association between dietary zinc intake and mortality among Chinese adults: findings from 10-year follow-up in the Jiangsu Nutrition Study

Abstract Aims We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. Materials and Methods A total of 16 257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose ≥ 7.0 mmol/L, or glycated hemoglobin ≥ 6.5% during the follow-up were defined as having new-onset diabetes. Results A total of 1097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearity < 0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intake < 9.1 mg/day (per mg/day: hazard ratio [HR], 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intake ≥ 9.1 mg/day (per mg/day: HR, 1.10; 95% CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -<12.2 mg/day), the risk of new-onset diabetes was higher for decile 1 (<8.9 mg/day: HR, 1.29; 95% CI, 1.04-1.62), and deciles 9 to 10 (≥12.2 mg/day: HR, 1.62; 95% CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearity < 0.001). Conclusions There was a U-shaped association between dietary zinc intake and new-onset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.

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Dietary Zinc Intake and Its Association with Metabolic Syndrome Indicators among Chinese Adults: An Analysis of the China Nutritional Transition Cohort Survey 2015

Nutrients ◽

10.3390/nu10050572 ◽

2018 ◽

Vol 10 (5) ◽

pp. 572 ◽

Cited By ~ 4

Author(s):

Yun Wang ◽

Xiao-Fang Jia ◽

Bing Zhang ◽

Zhi-Hong Wang ◽

Ji-Guo Zhang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Chinese Adults ◽

Dietary Zinc ◽

Zinc Intake ◽

Nutritional Transition

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Dietary zinc intake and the risk of depression in middle-aged men: A 20-year prospective follow-up study

Journal of Affective Disorders ◽

10.1016/j.jad.2013.03.027 ◽

2013 ◽

Vol 150 (2) ◽

pp. 682-685 ◽

Cited By ~ 25

Author(s):

Soili M. Lehto ◽

Anu Ruusunen ◽

Tommi Tolmunen ◽

Sari Voutilainen ◽

Tomi-Pekka Tuomainen ◽

...

Keyword(s):

Middle Aged ◽

Dietary Zinc ◽

Zinc Intake ◽

Follow Up Study

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2803 – Dietary zinc intake and the risk of depression in middle-aged men: a 20-year prospective follow-up study

European Psychiatry ◽

10.1016/s0924-9338(13)77391-7 ◽

2013 ◽

Vol 28 ◽

pp. 1

Author(s):

S.M. Lehto ◽

A. Ruusunen ◽

T. Tolmunen ◽

S. Voutilainen ◽

J. Kauhanen ◽

...

Keyword(s):

Middle Aged ◽

Dietary Zinc ◽

Zinc Intake ◽

Follow Up Study

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Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up

Nutrients ◽

10.3390/nu10101354 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1354 ◽

Cited By ~ 6

Author(s):

Yingting Cao ◽

Shiqi Zhen ◽

Anne Taylor ◽

Sarah Appleton ◽

Evan Atlantis ◽

...

Keyword(s):

Sleep Disorder ◽

Daytime Sleepiness ◽

Population Level ◽

Chinese Adults ◽

Magnesium Intake ◽

Falling Asleep ◽

Dietary Magnesium ◽

Nutrition Study

(1) Background: In clinical trials, dietary magnesium use can improve insomnia symptoms. However, little is known about the association between dietary magnesium consumption and sleep disorder symptoms including daytime falling asleep, sleepiness and snoring at the population level. (2) Methods: We used data from 1487 adults aged 20 and above attending the Jiangsu Nutrition Study. At baseline in 2002, dietary magnesium was assessed by 3-day weighed food records. At follow-up in 2007, sleep disorder symptoms, including daytime falling asleep, sleepiness and snoring at night, were gathered using a sleep questionnaire. (3) Results: The mean intake of magnesium was 332.5 mg/day. In total, 5.3%, 13.2% and 35.7% of the subjects reported daytime falling asleep, daytime sleepiness, and snoring during sleep, respectively. Compared with the lowest quartile of magnesium intake, the highest quartile was associated with decreased likelihood of falling asleep (odds ratio (OR) 0.12 (0.02, 0.57)) in women but not in men after adjusting for demographic, anthropometric, lifestyle factors, hypertension, and overall dietary patterns. No associations were found between dietary magnesium intake and daytime sleepiness nor night snoring in either gender. (4) Conclusions: Dietary magnesium intake may have long-term benefits in reducing the likelihood of daytime falling asleep in women.

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Zinc intake and the risk of hyperglycemia among Chinese adults: The prospective Jiangsu nutrition study (JIN)

The journal of nutrition health & aging ◽

10.1007/s12603-010-0075-0 ◽

2010 ◽

Vol 14 (4) ◽

pp. 332-335 ◽

Cited By ~ 14

Author(s):

Zumin Shi ◽

B. Yuan ◽

L. Qi ◽

Y. Dai ◽

H. Zuo ◽

...

Keyword(s):

Chinese Adults ◽

Zinc Intake ◽

Nutrition Study

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Bioavailability of zinc derived from beer and the effect of low dietary zinc intake on skeletal muscle zinc concentration

Nutrition Research ◽

10.1016/s0271-5317(85)80025-7 ◽

1985 ◽

Vol 5 (1) ◽

pp. 117-122 ◽

Cited By ~ 4

Author(s):

Charles R. Brown ◽

Peter J. Bechtel ◽

Richard M. Forbes ◽

Raymond S. Vogel

Keyword(s):

Skeletal Muscle ◽

Zinc Concentration ◽

Dietary Zinc ◽

Zinc Intake

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The role of zinc status in altered cardiac adenylate cyclase activity in diabetic rats

Acta Endocrinologica ◽

10.1530/acta.0.1190174 ◽

1988 ◽

Vol 119 (2) ◽

pp. 174-180 ◽

Cited By ~ 10

Author(s):

Arshag D. Mooradian ◽

John E. Morley ◽

Philip J. Scarpace

Keyword(s):

Adenylate Cyclase ◽

Adrenergic Receptor ◽

Diabetic Rats ◽

Cyclase Activity ◽

Adenylate Cyclase Activity ◽

Zinc Status ◽

Dietary Zinc ◽

Zinc Intake ◽

Diabetic State ◽

High Zinc

Abstract. Zinc deficiency and altered myocardial adenylate cyclase activity commonly occur in diabetes. To determine whether the zinc intake of the animal can account for the altered β-adrenergic receptor activity in the diabetic heart, we determined the β-adrenergic receptor number and isoproterenol-, NaF- and forskolin-stimulated adenylate cyclase activity in diabetic and control rats maintained on low, normal and high zinc diets for 3 weeks. Scatchard analysis of [125I]iodocyanopindolol binding to control heart membrane preparations revealed a binding capacity of 17.3 ± 1.3 fmol/mg protein with a Kd of 35 ± 1.0 pmol/l. Neither the diabetic state nor the zinc status altered these binding parameters. The isoproterenol-stimulated adenylate cyclase acticity was significantly lower in diabetic rats on low zinc diets compared with controls. The NaF- (65.1 ± 5.4 vs 60.8 ± 6.4 pmol cAMP·mg protein−1·min−1) and forskolin-stimulated adenylate cyclase activities (161 ± 9.3 vs 154 ± 21.2 pmol cAMP·mg protein−1· min−1) were not significantly altered in diabetic rats. Low dietary zinc intake compared with high zinc diet significantly increased NaF- and forskolin-stimulated adenylate cyclase activity both in diabetic rats and controls. The effect of dietary zinc content on isoproterenol-stimulated adenylate cyclase was significant in control rats only. Thus zinc intake appears to be an important determinant of cardiac adenylate cyclase activity level. Additional factors peculiar to the diabetic state are involved in the modulation of β-adrenergic responsiveness of the diabetic heart.

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Relationship between alcohol consumption and cancer in rural Chinese adults: 1 5- year follow-up cohort study

10.21203/rs.3.rs-48959/v1 ◽

2020 ◽

Author(s):

Yue Zhang ◽

Jingyi Li ◽

Nannan Cheng ◽

Jie Yang ◽

Lijing Ye ◽

...

Keyword(s):

Cohort Study ◽

Alcohol Consumption ◽

Cancer Incidence ◽

Rural China ◽

Density Lipoprotein ◽

Estimating Equation ◽

Chinese Adults ◽

Increased Risk ◽

Risk Of Cancer

Abstract Background：We aimed to evaluate the association between alcohol consumption and risk of cancer incidence among rural Chinese adults. Methods: We utilized data from a community-based cohort study in rural China enrolled in 2003 and followed up prospectively up to 2018. Generalized estimating equation models were used to obtain odds ratios (OR) and 95% confidence intervals (CI) to analyze the relationship between alcohol consumption and cancer incidence. Results: After an average of 15 years of follow-up, a total of 9870 adult participants were included in this study. The results of the regression analysis for males showed that former drinkers had a significantly increased risk of cancer compared to never drinkers ([OR]2.46,95%[CI](1.43-4.23)). The cancer risk for current drinkers with heavy alcohol consumption(>400g/week) significantly increased ([OR]1.66,95% [CI] (1.18-2.34))compared to never drinkers. Among current drinkers, for every 100g of alcohol consumed per week, the risk of cancer increased by 15%. Among current drinkers, those aged 53.5 years or older , had a significant increase in the risk of cancer ([OR]1.26,95% [CI](1.12-1.42), for those with triglycerides ≥150 mg/dL, the risk of cancer was even higher ([OR]1.50,95%[CI](1.20-1.88), P for interaction 0.018), and for those with high density lipoprotein cholesterol (HDLC)<40 mg/dL, the risk of cancer increased the greatest ([OR]2.03,95%[CI](1.36-3.04), P for interaction 0.005). Conclusions: Among middle-aged and elderly males in rural China, the risk of cancer significantly increased among former and heavy current drinkers compared with never drinkers. Age, triglycerides, and HDLC may increase the risk of cancer along with alcohol consumption.

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Long-term BMI change trajectories in Chinese adults and its association with the hazard of type 2 diabetes: evidence from a 20-year China Health and Nutrition Survey

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2019-000879 ◽

2020 ◽

Vol 8 (1) ◽

pp. e000879

Author(s):

Baibing Mi ◽

Chenlu Wu ◽

Xiangyu Gao ◽

Wentao Wu ◽

Jiaoyang Du ◽

...

Keyword(s):

Type 2 Diabetes ◽

Latent Class ◽

Chinese Adults ◽

Change Trajectories ◽

Nutrition Survey ◽

Health And Nutrition ◽

Increased Risk

IntroductionTo investigate the relationship between long-term change trajectory in body mass index (BMI) and the hazard of type 2 diabetes among Chinese adults.Research design and methodsData were obtained from the China Health and Nutrition Survey (CHNS). Type 2 diabetes was reported by participants themselves in each survey wave. The duration of follow-up was defined as the period from the first visit to the first time self-reported type 2 diabetes, death, or other loss to follow-up from CHNS. The patterns of change trajectories in BMI were derived by latent class trajectory analysis method. The Fine and Gray regression model was used to estimate HRs with corresponding 95% CIs for type 2 diabetes.ResultsFour patterns of the trajectories of change in BMI were identified among Chinese adults, 42.7% of participants had stable BMI change, 40.8% for moderate BMI gain, 8.9% for substantial BMI gain and 7.7% for weight loss. During the follow-up with mean 11.2 years (158 637 person-years contributed by 14 185 participants), 498 people with type 2 diabetes (3.7%) occurred. Risk of type 2 diabetes was increased by 47% among people who gained BMI more substantially and rapidly (HR: 1.47, 95% CI 1.08 to 2.02, p=0.016) and increased by 20% among those in people with the moderate BMI gain (HR: 1.20, 95% CI 0.98 to 1.48, p=0.078), compared with those with stable BMI change.ConclusionsLong-term substantial gain of BMI was significantly associated with an increased risk of type 2 diabetes in the Chinese adults.

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