Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP)

2012 ◽  
Vol 107 (3) ◽  
Author(s):  
Christian Kuhn ◽  
Derk Frank ◽  
Franziska Dierck ◽  
Ulrike Oehl ◽  
Jutta Krebs ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Lim Protein ◽  
Muscle Lim Protein

scholarly journals Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc

2005 ◽  
Vol 102 (5) ◽  
pp. 1655-1660 ◽  
Author(s):  
J. Heineke ◽  
H. Ruetten ◽  
C. Willenbockel ◽  
S. C. Gross ◽  
M. Naguib ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Remodeling ◽  
Lim Protein ◽  
Muscle Lim Protein ◽  
Calcineurin Signaling

scholarly journals Muscle LIM protein/CSRP3: a mechanosensor with a role in autophagy

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
M M Rashid ◽  
A Runci ◽  
L Polletta ◽  
I Carnevale ◽  
E Morgante ◽  
...  
Keyword(s):  
Lim Protein ◽  
Muscle Lim Protein

A role for muscle LIM protein (MLP) in vascular remodeling

2006 ◽  
Vol 40 (4) ◽  
pp. 503-509 ◽  
Author(s):  
Xiaohong Wang ◽  
Qinglu Li ◽  
Neeta Adhikari ◽  
Jennifer L. Hall
Keyword(s):  
Vascular Remodeling ◽  
Lim Protein ◽  
Muscle Lim Protein

scholarly journals Muscle LIM Protein: Master regulator of cardiac and skeletal muscle functions

Gene ◽  
2015 ◽  
Vol 566 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Elizabeth Vafiadaki ◽  
Demetrios A. Arvanitis ◽  
Despina Sanoudou
Keyword(s):  
Skeletal Muscle ◽  
Master Regulator ◽  
Lim Protein ◽  
Muscle Lim Protein ◽  
Muscle Functions

Muscle LIM protein plays both structural and functional roles in skeletal muscle

2005 ◽  
Vol 289 (5) ◽  
pp. C1312-C1320 ◽  
Author(s):  
Ilona A. Barash ◽  
Liby Mathew ◽  
Michele Lahey ◽  
Marion L. Greaser ◽  
Richard L. Lieber
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Tissue ◽  
Fiber Type ◽  
Eccentric Contraction ◽  
Recovery Process ◽  
Type I ◽  
Muscle Injuries ◽  
Functional Roles ◽  
Lim Protein ◽  
Muscle Lim Protein

Muscle LIM protein (MLP) has been suggested to be an important mediator of mechanical stress in cardiac tissue, but the role that it plays in skeletal muscle remains unclear. Previous studies have shown that it is dramatically upregulated in fast-to-slow fiber-type transformation and also after eccentric contraction (EC)-induced muscle injury. The functional consequences of this upregulation, if any, are unclear. In the present study, we have examined the skeletal muscle phenotype of MLP-knockout (MLPKO) mice in terms of their response to EC-induced muscle injuries. The data suggest that while the MLPKO mice recover completely after EC-induced injury, their torque production lags behind that of heterozygous littermates in the early stages of the recovery process. This lag is accompanied by decreased expression of the muscle regulatory factor MyoD, suggesting that MLP may influence gene expression. In addition, there is evidence of type I fiber atrophy and a shorter resting sarcomere length in the MLPKO mice, but no significant differences in fiber type distribution. In summary, MLP appears to play a subtle role in the maintenance of normal muscle characteristics and in the early events of the recovery process of skeletal muscle to injury, serving both structural and gene-regulatory roles.

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