Comparative study of p16 protein expression in squamous cell carcinomas from patients with epidermodysplasia verruciformis and patients without the disease

2017 ◽  
Vol 309 (6) ◽  
pp. 479-483 ◽  
Author(s):  
Mayra S. G. Mattos ◽  
Walmar R. Oliveira ◽  
Mirian N. Sotto
Keyword(s):  
Protein Expression ◽  
Comparative Study ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Epidermodysplasia Verruciformis ◽  
P16 Protein

scholarly journals Does P16 protein expression affect treatment prognosis in oral squamous cell carcinoma - A comparative study

2021 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
MohammadAmir Alizadeh Tabrizi ◽  
Mitra Rezaei ◽  
Hassan Mohajerani ◽  
Hamidreza Moslemi ◽  
Shervin Shafiei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Comparative Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P16 Protein ◽  
Treatment Prognosis

scholarly journals Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l]pyrene diol epoxide

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259998
Author(s):  
Douglas B. Stairs ◽  
Mary E. Landmesser ◽  
Cesar Aliaga ◽  
Kun-Ming Chen ◽  
Yuan-Wan Sun ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Immune Cells ◽  
Active Metabolite ◽  
Squamous Cell Carcinomas ◽  
Tobacco Smoke Exposure ◽  
Black Raspberry ◽  
Chemopreventive Agent ◽  
Diol Epoxide ◽  
Egfr Expression

One of the major risk factors for head and neck squamous cell carcinoma (HNSCC) is tobacco smoke exposure, but the mechanisms that can account for disease development remain to be fully defined. Utilizing our HNSCC mouse model, we analyzed oral squamous cell carcinomas (OSCC) induced by the active metabolite of a common smoke constituent, dibenzo[a,l]pyrene diol-epoxide (DBPDE). Analyzing protein expression by either immunofluorescence or immunohistochemistry, we identified biologic processes that are dysregulated in premalignant and invasive cancer lesions induced by DBPDE. Interestingly, p120ctn expression is downregulated in both stages of the disease. In addition to decreased p120ctn expression, there was also increased proliferation (as measured by Ki67), inflammation (as measured by NFkB (p65) expression), neovascularization (as measured by CD31) and recruitment of Ly6G-positive immune cells as well as strong EGFR expression. We also examined the effect of the chemopreventive agent black raspberry (BRB) on p120ctn and EGFR protein expression in DBPDE treated mice. p120ctn, but not EGFR, protein expression increased in mice treated with BRB. Our results suggest that modulation of p120ctn may, in part, account for the mechanism by which BRB inhibits DBPDE induced OSCC in mice.

Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas

2007 ◽  
Vol 28 (10) ◽  
pp. 433-437 ◽  
Author(s):  
W. F. P. Heerden ◽  
T. J. P. Swart ◽  
M. B. Heerden ◽  
E. J. Rensburg ◽  
S. Engelbrecht ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Fhit Protein

Analysis of αv integrin protein expression in human eyelid and periorbital squamous cell carcinomas

2011 ◽  
Vol 38 (7) ◽  
pp. 570-575 ◽  
Author(s):  
Adam Hsu ◽  
Bita Esmaeli ◽  
Brent Hayek ◽  
Mohammad G. Hossain ◽  
Roman Shinder ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas
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