Spontaneous or interferon-γ-induced T-cell infiltration, HLA-DR and ICAM-1 expression in genitoanal warts are associated with TH1 or mixed TH1/TH2 cytokine mRNA expression profiles

1997 ◽  
Vol 289 (5) ◽  
pp. 243-250 ◽  
Author(s):  
A. Grassegger ◽  
Ingrid Rollinger-Holzinger ◽  
Bernhard W. H. Zelger ◽  
Kurt Heim ◽  
Heinz Zwierzina ◽  
...  
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
Expression Profiles ◽  
Interferon Γ ◽  
Cell Infiltration ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression ◽  
T Cell Infiltration ◽  
Th2 Cytokine ◽  
Hla Dr

Th2 Cytokine mRNA Expression in Skin in Cutaneous T-Cell Lymphoma

1994 ◽  
Vol 103 (5) ◽  
pp. 669-673 ◽  
Author(s):  
Benjamin R Vowels ◽  
Stuart R Lessin ◽  
Maureen Cassin ◽  
Christine Jaworsky ◽  
Bernice Benoit ◽  
...  
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression ◽  
Th2 Cytokine

scholarly journals Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets

Virology ◽  
2007 ◽  
Vol 362 (2) ◽  
pp. 404-410 ◽  
Author(s):  
Nicholas Svitek ◽  
Veronika von Messling
Keyword(s):  
Mrna Expression ◽  
Expression Profiles ◽  
Disease Outcome ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression

scholarly journals Th1 and Th2 Cytokine mRNA Profiles in Childhood Nephrotic Syndrome

1999 ◽  
Vol 10 (3) ◽  
pp. 529-537
Author(s):  
HUI-KIM YAP ◽  
WAI CHEUNG ◽  
BELINDA MURUGASU ◽  
SZE-KEEN SIM ◽  
CHING-CHING SEAH ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
T Cell ◽  
Mrna Expression ◽  
T Cell Activation ◽  
Viral Infections ◽  
Interleukin 2 ◽  
Interferon Γ ◽  
Paired Data ◽  
Cytokine Mrna ◽  
Significant Difference

Abstract. Idiopathic nephrotic syndrome of childhood is thought to be associated with T lymphocyte dysfunction often triggered by viral infections, with the production of circulating factor(s) resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2 pattern of cytokine synthesis in this disease, this study examined the mRNA expression of interleukin-2 (IL-2), interferon-γ, IL-4, and IL-13 from CD4+ and CD8+ T cells in steroid-responsive nephrotic patients in relapse and remission. Fifty-five children with steroid-responsive nephrotic syndrome were included in this study, together with 34 normal controls and 24 patient controls with viral infections. RNA was isolated from purified CD4+ or CD8+ cells from peripheral blood and subjected to reverse transcription-PCR. Cytokine mRNA expression was measured semiquantitatively, and a cytokine index was derived from densitometric readings, with cyclophilin as the housekeeping gene. Both cross-sectional and paired data showed an increased CD4+ and CD8+ IL-13 mRNA expression in patients with nephrotic relapse as compared to remission, normal, and patient controls (P <0.008). This was also associated with increased cytoplasmic IL-13 expression in phorbol myristate acetate/ionomycin-activated CD3+ cells (6.66 ± 3.39%) from patients with nephrotic relapse compared to remission (2.59 ± 1.35%) (P < 0.0001). However, there was no significant difference in CD4+ or CD8+ IL-2, interferon-γ and IL-4 mRNA expression. IL-13 is an important T cell cytokine with anti-inflammatory and immunomodulatory functions on B cells and monocytes. It is conceivable that IL-13 may act on monocytes to produce vascular permeability factor(s) involved in the pathogenesis of proteinuria in patients with relapse nephrotic syndrome.

Quantitive Cytokine mRNA Expression Profiles in the Colonic Mucosa of Patients with Steroid Naïve Ulcerative Colitis During Active and Quiescent Disease

2009 ◽  
Vol 15 (3) ◽  
pp. 328-334 ◽  
Author(s):  
Reikei Matsuda ◽  
Tomoko Koide ◽  
Chikako Tokoro ◽  
Tsuyoshi Yamamoto ◽  
Tenʼi Godai ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Mrna Expression ◽  
Colonic Mucosa ◽  
Expression Profiles ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression ◽  
Quiescent Disease

scholarly journals Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial

2019 ◽  
Vol 7 (8) ◽  
pp. 1237-1243 ◽  
Author(s):  
Shihong Zhang ◽  
Karan Kohli ◽  
R. Graeme Black ◽  
Lu Yao ◽  
Sydney M. Spadinger ◽  
...  
Keyword(s):  
Clinical Trial ◽  
T Cell ◽  
Mhc Class I ◽  
Interferon Γ ◽  
Class I ◽  
Cell Infiltration ◽  
T Cell Infiltration ◽  
Phase 0

scholarly journals Selected Th1 and Th2 cytokine mRNA expression by CD4+ T cells isolated from inflamed human gingival tissues

2007 ◽  
Vol 103 (3) ◽  
pp. 422-428 ◽  
Author(s):  
K. FUJIHASHI ◽  
M. YAMAMOTO ◽  
T. HIROI ◽  
T. V. BAMBERG ◽  
J. R. MCGHEE ◽  
...  
Keyword(s):  
T Cells ◽  
Mrna Expression ◽  
Cd4 T Cells ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression ◽  
Th2 Cytokine ◽  
Th1 And Th2
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